ADME 101 Webinar: Considerations & Calculations When Sending In Vitro Test Articles



April 9, 2020

Presenter: Patrick McAnulty, SEKISUI XenoTech Scientist II, Program Design This ADME 101 webinar discusses the #1 most frequently asked question that our Protocol Design team receives: “How much test article do I need to send for an in vitro drug metabolism or drug-drug interaction study?” The video outlines the important factors to consider when calculating the quantities of test article needed for top treatment concentrations that will meet regulatory guidance recommendations, including: - What are the properties of the test article? - What is the scope of the work? - What concentrations do the guidance documents say need to be tested? - What concentration of stock solution needs to be made? - What solvent percentage can we use in our incubation solutions? - Common concerns and more... About the presenter: Patrick McAnulty has a Master of Science in Biomedical Sciences from the University of Missouri - Columbia. As a Scientist II in SEKISUI XenoTech's Program Design department, Patrick is responsible for preparing study protocols for disciplines such as enzyme inhibition, enzyme induction, drug metabolism, drug transport, and metabolic profiling. Download slides: Questions, comments and requests: More information on our research services and test systems: Other previously aired webinars: Upcoming webinar notifications: Request a webinar topic:

Cancer ResearchDrug DiscoveryMass Spectrometry

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