How to Make Pharmaceutical Emulsions, Creams and Ointments

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Silverson Machines

When making a pharmaceutical cream or ointment a fine, stable emulsion with good dispersion of Active Pharmaceutical Ingredients (API) is essential for creating the right consistency and functionality in the end product.

A Silverson mixer can easily create a homogeneous, stable emulsion with a droplet size of 2 to 5 microns. Finer emulsions can be obtained depending on the formulation. The high shear mixing action of a Silverson rotor/stator mixer can rapidly disperse API and other ingredients in the formulation.

Silverson is a pioneer in the development of ultra hygienic, sanitary mixing equipment for the Pharmaceutical industry which meets or exceeds all guidelines set by the regulatory bodies.

For low to medium viscosities, we recommend a Batch mixer for smaller volumes. For higher viscosities mixes, a High Shear Bottom Entry mixer with scraper/stirrer to maintain uniformity in the vessel.

For larger batches, a Silverson In-Line mixer recirculating the contents of the vessel will produce a fine, homogeneous emulsion.

To find out more about the Production of Pharmaceutical Creams and Ointments, read the Silverson application report at: https://www.silverson.co.uk/en/resource-library/application-reports/production-of-pharmaceutical-cream-and-ointments-uk