HDX for understanding a protein's higher order structure and function | Behind the Science



September 30, 2018

How do researchers understand how proteins interact in the body? In #BehindtheScience, Jen meets Waters principal scientist Keith Fadgen. He compares two techniques, x-ray crystallography and hydrogen-deuterium exhange (HDX). X-ray crystallography can be used to determine the atomic and molecular structure of a crystal. HDX can be used to study protein-protein interactions over a course of time, which is useful for common biopharmacuetical studies such as epitope mapping, formulation stability testing, and understanding how diseases and viruses function. Keith explains how Waters collaborated with academic labs to make HDX experiments robust and reliable.

Analytical TechniquesChromatographyMass Spectrometry

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