Solid stress in brain tumours causes neuronal loss and neurological dysfunction and can be reversed by lithium. Seano G, Nia HT, Emblem KE, Datta M, Ren J, Krishnan S, Kloepper J, Pinho M, Ho WW, Ghosh M, Askoxylakis V, Ferraro GB, Riedemann L, Gerstner ER, Batchelor TT, Wen PY, Lin NU, Grodzinsky AJ, Fukumura D, Huang P, Baish JW, Padera TP, Munn LL, Jain RK.
Nature Biomedical Engineering. 2019
Preservation of neurological function is increasingly taken into consideration in current clinical practice, and neuro-oncologists now consider the quality of life as a critical end-point. Our results identify solid stress as one of the causes of brain tumor-induced loss of neurological functions.
- This study revealed that nodular tumors exerts more mechanical stress to the brain tissue than infiltrative tumors and a new patients stratification method allowed us to identify which patients may experience solid stress-mediated neurological impairment.
- For the first time, we directly and mechanistically demonstrated that chronic and gradual solid stress applied to the brain causes neurological impairment and we showed some of the biological consequences of tumor mechanics to the brain, such as vessel compression and neuronal damage.
- We finally tested the potential of lithium treatment as a neuroprotection strategy for mechanically-damaged neurons