Are sample prep approaches the same for both large and small molecules? | Trust Your Science 17

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January 11, 2019

When working with peptides, can you use the same sample preparation methods as small molecules? In #TrustYourScience, Kim and Jon test reversed-phase solid phase extraction (SPE), protein precipitation (PPT), and liquid-liquid extraction (LLE) protocols for two peptides, using greater than 80% recovery and less than 15% matrix effects as success criteria. Watch to see what they learn.

Analytical TechniquesChromatographyMass Spectrometry

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