Solving of the Structure of Misfolded Tau in Pick's Disease

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Technology Networks

Dr Sjors Scheres, Group Leader at the MRC's Laboratory of Molecular Biology, UK, discusses his latest research solving the structure of misfolded tau in Pick's Disease (Frontotemporal Dementia, FTD). Using Cryo-EM the group solved the structure of the misfolded tau protein isolated from the brain of a patient that had died of FTD at the molecular level, approaching 3 Angstroms resolution. Sjors explains how Cryo-EM works, and how the group used it to make their findings. He also explains the impact these fundamental findings will have on the field and human health.