Using Mixed-Mode Selectivity to Address Purification Challenges

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Bio-Rad Laboratories

"For more information, visit http://www.bio-rad.com/yt/2/Process-Chromatography As the structures of novel biotherapeutics become more diverse, new purification schemes are emerging to effectively address purification challenges. Mixed-mode chromatography resins, with their unique selectivities, are emerging as powerful tools for the removal of product-related impurities. In this webinar, we discuss ligand-protein interactions and present several applications of mixed-mode chromatography, with a special focus on orthogonal approaches used to effectively remove closely related species while reducing feed manipulation and buffer consumption. Finally, we present proven approaches to accelerate method development by fine-tuning selectivity with minimal experimentation. Application highlights include several cases spanning a range of proteins. Presenter: Xumei He, PhD Staff Scientist, Bio-Rad Process Chromatography Applications http://www.bio-rad.com/en-us/process-separations?WT.mc_id=yt-pcd-ww-process-chrom-20140730-Rv7a3xI4Yn8"