Automating mAb Workflows: Combining Multidimensional (Multi-D) Purifications with Product Analysis



March 3, 2017

"For more information, visit: In this poster presentation, Bio-Rad's Jeff Habel provides a description of a fully automated protein purification and in-line analysis combining a Multi-D method with analytical product characterization. It demonstrates the NGC System’s unique ability of saving the elution from tandem purifications into a loop valve (for further purification) and analyzing a small fraction of the purified product for aggregates by analytical size exclusion chromatography. Bio-Rad's NGC Preparative Chromatography Systems are designed to rapidly automate the purification of biomolecules. The flexible, modular, and economical design makes the NGC Systems the instruments of choice for method development and scale-up. NGC Systems are available in pre-plumbed, factory-tested configurations with two different flow rates. Each preconfigured system can be further customized and upgraded by adding valves, detectors, or pumps to meet specific application needs, such as tandem and 2D chromatography. Any system can be configured for operation at either high or low flow rate by simply changing the pump head on the system pump module. With the NGC System, a single hardware platform can be modified as needed to suit changing applications and scales. Design your system for your application and throughput needs."


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