Biomarker Profiling in Diabetes and Cardiovascular Disease



February 21, 2017

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  • "For more info, visit In this webinar, Dr. James Mapes, Chief Scientific Officer of Myriad RBM, discusses the validation and application of novel multiplex immunoassays for diabetes metabolic biomarkers. Diabetes mellitus (DM) is a serious metabolic disorder that afflicts more than 370 million people worldwide, with 90% having Type 2 (T2DM), which results in life-threatening complications including chronic kidney failure and cardiovascular disease. In fact, 65% of Type 2 diabetics die prematurely of heart disease or stroke. With the goal of improving diabetes care, scientists are actively searching for novel biomarkers that can predict the onset of disease and inform clinicians about the efficacy of both lifestyle changes and drug interventions. A wide range of candidate markers are under investigation including gut and pituitary hormones, acute phase proteins, adipokines, cytokines, proteinases, nutrient binding proteins, and growth factors. When studied together, these markers can help researchers elucidate the complex relationship between metabolic and cardiovascular diseases, and ultimately enable more effective and personalized disease treatment. Both pharmaceutical and academic researchers can benefit greatly from the ability to analyze multiple disease-associated biomarkers in each patient sample. The Bio-Plex® Multiplex Immunoassay System can simultaneously quantify up to 100 different proteins, peptides, and DNA or RNA fragments from a single sample, with sample volumes as low as 50 µl, in a 96-well format. The capabilities of the Bio-Plex System allow researchers to conserve precious samples, reduce assay expense and labor, and dramatically increase the amount of data obtained from a single sample. This technology enables scientists to generate more information on the relationships among analytes in a given biological system, with better correlation with in vivo assays."


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