FLIPR® Tetra High Throughput Cellular Screening System

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Molecular Devices

Industry-renowned, flexible, and reliable real time kinetic cellular assay screening system for identifying early leads against GPCR and ion channel receptors The FLIPR® Tetra High Throughput Cellular Screening System from Molecular Devices, LLC., is an industry-renowned, flexible, and reliable real time kinetic cellular assay screening system for identifying early leads against GPCR and ion channel receptors. The system features simultaneous pipette and read capability which makes the system ideal for fast kinetic cellular assays, such as calcium flux. User and assay needs vary during the different stages of the drug discovery screening process. For this reason, we designed the FLIPR Tetra System to be user-configurable. The system is available with either a fluorescence or luminescence camera. Using the luminescence camera, users can rapidly configure and switch between fluorescence and luminescence read modes. The gain of the luminescence camera can be adjusted to the appropriate signal window to detect signals from dim luminescence to bright fluorescence assays. LED banks and emission filters can be exchanged by the user in approximately 10 minutes and provides the flexibility to perform experiments using the best fluorescent dye for the selected assay. A slider which holds up to three emission filters enables the FLIPR Tetra System to be quickly configured for different single wavelength detection assays such as calcium mobilization and membrane potential or ratiometric assays. To accommodate different throughput needs and assay requirements, five different pipettor heads are available which can pipette reagents, compounds or cells. Whether you require 96-, 384-, 1536-well format or 384 or 1536 pin tools, pipettor heads can easily be changed by the user in minutes. An optional cell suspension system for the FLIPR Tetra System increases throughput by eliminating the need to plate cells and the need for separate compound plates during aequorin assays.