A Solutions Manager at Thermo Fisher Scientific, Rainer Bauder, talks about a newly developed concept using 250mm UHPLC columns combined with the Thermo Scientific UltiMate 3000 XRS system. The 250mm UHPLC columns allow scientists to better understand an unknown sample or unfamiliar matrix. The UltiMate 3000 XRS quaternary UHPLC system is designed to optimize performance of small i.d. UHPLC columns while providing perfect LC/MS integration and pressures up to 1250 bar.