Stem Cells

Teach Me in 10

3D cell culture has gained rapid adoption in recent years and it’s no wonder with the many benefits these more physiologically relevant models can deliver. There are several ways you can create a 3D model, but it depends on what the goals of your study are. Join this “Teach Me in 10” session to hear Corning Life Sciences application scientists walk you through common research goals and the most suitable 3D cell culture solutions for each.

How To Choose Your Tools for 3D Cell Culture With Audrey Bergeron and Hilary Sherman

This installment of Teach Me in 10 features [url][link]https://www.cardiff.ac.uk/people/view/81217-lelos-mariah[/link][name]Dr Mariah Lelos[/name][/url], a senior lecturer at Cardiff University. Dr Lelos teaches Cellular and Molecular Biology modules at Master's level at the university. Her particular interest is in  understanding the manifestation of motor and non-motor (cognitive, neuropsychiatric) dysfunctions in degenerative diseases using lesion, viral vector and genetically modified rodent models. Watch this Teach Me in 10 to discover why stem cells are an emerging treatment for neurological diseases such as Parkinson's and Huntington's.

Why Use Stem Cells To Treat Neurological Diseases? With Dr Mariah Lelos

Science communicators serve an important role, bridging researchers with scientists in other fields, science professionals, industry experts and the general public. "How do I become a science writer?" is a common question that we get asked here at Technology Networks. That is why for this installment of Teach Me in 10, the guests are … well, us! We wanted to share stories of how we became science writers and communicators, highlighting some of the things that we have learned through our journeys and to offer some top tips and tricks. Further resources: [url][link]https://www.technologynetworks.com/tn/how-to-guides/how-to-become-a-science-writer-8-tips-to-guide-you-312458[/link][name]8 Tips on How To Become a Science Writer[/name][/url], [url][link]https://www.technologynetworks.com/tn/meet-the-team[/link][name]Meet the Technology Networks Team[/name][/url].

Becoming a Science Writer

Don Whitley Scientific

The H135 GMP Hypoxystation has been specifically designed to be used as a clean-air isolator in processes following Good Manufacturing Practice (GMP). This new workstation provides Grade A air cleanliness (EU GMP) and combines sterile laminar airflow, positive operating pressure, and physical isolation, to provide highly effective product protection. Due to being a completely closed, re-circulating, isolator system, this workstation can be housed in a Grade D cleanroom during GMP compliant use.

Whitley H135 GMP Hypoxystation

Now – more than ever before – it's critical that pharma QA/QC labs have solutions in place that enable them to deliver medicines faster and safely. How are digital solutions being used to enable pharma manufacturing, particularly in such labs? That is the topic of focus for this industry special of Teach Me in 10, where we're joined by Dr Stephen Moore, Services Manager, Digital Science, Thermo Fisher Scientific. With 16 years’ industrial experience in clinical diagnostics, genomics and informatics, including laboratory operation, bioinformatics, project management and scientific software implementations, Stephen has built a wealth of knowledge and expertise around LIMS project requirements. Here, he looks at the common challenges experienced by pharmaceutical QA/QC laboratories looking to implement laboratory software solutions, on their digital transformation journey. He discusses the latest digital technologies available to labs, and bring to you some expert advice and guidance for project planning and management to help you ensure successful, timely delivery of your laboratory software solution.

Teach Me in 10 – Enabling Pharma Manufacturing Through Digital Solutions With Dr Stephen Moore 

CN Bio

Despite the complex physiologically relevant 3D biology that it recreates in vitro, our PhysioMimix™ OOC Microphysiological System is rather simple to adopt, helping you transition from 2D into 3D cell culture with ease. Through its ability to recreate human physiology in the lab, the PhysioMimix™ OOC can predict human responses to new therapeutic drug candidates. By supplementing data generated from entrenched 2D cell culture and animal studies, this system supports confident decision making across many drug discovery stages from target discovery right through to development.

PhysioMimix™ OOC Lab Benchtop Ready Microphysiological System

Distek, Inc.

Distek has revolutionized benchtop scale bioprocessing with the release of our BIOne 1250 Bioprocessing Controller and BIOne Single-Use Bioreactor. 

With the intuitive touchscreen interface, the BIOne 1250 is designed to be the easiest to use and most capable stand-alone controller on the market.  

With the BIOne Single-Use Bioreactor any existing 2 and 5L autoclavable system can be easily converted into a fully contained single-use system.  Simply remove the existing stainless steel headplate and place the BIOne SUB directly into the Glass Vessel.

Distek BIOne

Wyss Institute for Biologically Inspired Engineering at Harvard University

With the goal of rapidly repurposing FDA-approved drugs to treat COVID-19, the Wyss Institute is collaborating with the Frieman Lab at the University of Maryland Medical School and the tenOever Lab at the Icahn School of Medicine at Mount Sinai to establish a multidisciplinary pipeline that can rapidly predict, test, and validate potential treatments. For more information, please visit: https://wyss.harvard.edu/news/repurposing-approved-drugs-for-covid-19-at-an-accelerated-pace Credit: Wyss Institute at Harvard University

Beating Back the Coronavirus: FDA-Approved Drug Repurposing Pipeline

PerkinElmer 

The MuviCyte system is designed to operate inside your incubator, so you can maintain your cells under optimal conditions, keeping them healthy for weeks at a time. Controlled by an external PC, you can observe your cells remotely, which helps to keep the culture chamber at optimum levels of temperature, CO2, and humidity. The automated operation allows you to focus on your science while the instrument runs unattended. With three-color fluorescence imaging, z-stacking, and stitching capabilities, you can perform a wide range of assays in a variety of culture vessels, e.g. chamber slides, petri dishes, flasks, microplates. Automated imaging, over hours to days, means your assays can be run at much higher throughput than with a traditional microscope. The system has built-in image analysis software for assays such as cell health and viability, transfection efficiency, reporter gene, apoptosis and proliferation, and optional software available for scratch wound and spheroid assays. The flexible movie-making software provides a great way to gain more realistic and meaningful insights into cell behavior, functions, and responses. Features and benefits •	Operates inside incubator - Provides optimal environmental conditions to keep cells healthy for long-term kinetic assays or use a hypoxia incubator for imaging under hypoxic conditions. •	Benchtop operation - Use the instrument on the bench with the lid (included) or inside a cell culture incubator. •	Open design - Provides flexibility to use the culture vessels of your choice, such as microfluidics platforms. •	Three-color fluorescence plus brightfield imaging - Flexibility to work label-free or select from a wide range of dyes and fluorescent proteins, and you can save time by analyzing more cell features using multiple markers at the same time. •	4x, 10x, and 20x (LWD) objectives, digital zoom - Flexibility to work with a range of magnifications for different cell applications. •	Image-based autofocus - uses image features to select the focus position. The focus is dependent on the cells, not the sample carrier, giving you a stable focus on the cells. •	Custom autofocus - you can focus on defined structure within your cell sample by adjusting the reference z-height for the autofocus. •	Unlimited and flexible imaging positions (FOVs) within wells - Choose imaging positions freely within the well to capture cells of interest, from small cell colonies to entire wells, without a pre-defined grid. •	Image stitching - Create a stitched image, enabling analysis of larger objects such as tissue sections, stem cell colonies, or an entire well. •	Z-stacking - Extends the range of imaging in the z-direction for 3D objects or thicker samples such as spheroids. •	Automated operation - Delivers faster imaging and is less prone to error than a manually operated research microscope. •	Image quantification software for commonly used assays - Easier and faster than with a manual microscope, and more reliable quantification than by manual methods. •	Movie Maker - Enables easy moviemaking and has multiple movie modes (single, sequence, and matrix) enabling you to compare multiple wells side by side, interpret cell responses. •	Annotation list - Annotate your areas of interest on the images while setting up the measurement to help you find important positions over time. Ensures you can find specific items of interest, e.g. particular cells, stem cell colonies or regions of interest on tissue slices. •	Open data format - Easily access and share data with colleagues. You can set the image format to TIF, PNG, JPEG or BMP. •	Global on-site service - Receive on-site service globally from a local service engineer to minimize instrument down time. Typical applications and assays •	Cell health and viability •	Transfection efficiency •	Scratch wound •	Spheroid analysis •	Apoptosis •	Cellular localization •	Neurite outgrowth •	Fluorescent cell counting •	Proliferation •	Stem cell monitoring •	Cell morphology

Stem Cells

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