Stem Cells

Lucid Scientific

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Aging

Abstract:
Heterochronic blood sharing rejuvenates old tissues, and most of the studies on how this works focus on young plasma, its fractions, and a few youthful systemic candidates. However, it was not formally established that young blood is necessary for this multi-tissue rejuvenation. Here, using our recently developed small animal blood exchange process, we replaced half of the plasma in mice with saline containing 5% albumin (terming it a “neutral” age blood exchange, NBE) thus diluting the plasma factors and replenishing the albumin that would be diminished if only saline was used. Our data demonstrate that a single NBE suffices to meet or exceed the rejuvenative effects of enhancing muscle repair, reducing liver adiposity and fibrosis, and increasing hippocampal neurogenesis in old mice, all the key outcomes seen after blood heterochronicity. Comparative proteomic analysis on serum from NBE, and from a similar human clinical procedure of therapeutic plasma exchange (TPE), revealed a molecular re-setting of the systemic signaling milieu, interestingly, elevating the levels of some proteins, which broadly coordinate tissue maintenance and repair and promote immune responses. Moreover, a single TPE yielded functional blood rejuvenation, abrogating the typical old serum inhibition of progenitor cell proliferation. Ectopically added albumin does not seem to be the sole determinant of such rejuvenation, and levels of albumin do not decrease with age nor are increased by NBE/TPE. A model of action (supported by a large body of published data) is that significant dilution of autoregulatory proteins that crosstalk to multiple signaling pathways (with their own feedback loops) would, through changes in gene expression, have long-lasting molecular and functional effects that are consistent with our observations. This work improves our understanding of the systemic paradigms of multi-tissue rejuvenation and suggest a novel and immediate use of the FDA approved TPE for improving the health and resilience of older people.

To date, this study has generated an Altmetric Attention Score of 140. The Altmetric Attention Score provides an at-a-glance indication of the volume and type of online attention the research has received. 

Top Aging publications rated by Altmetric score -  https://www.aging-us.com/news_room/altmetric

Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.103418

DOI - https://doi.org/10.18632/aging.103418

Full text - https://www.aging-us.com/article/103418/text

Correspondence to: Irina M. Conboy email: iconboy@berkeley.edu

Keywords: blood exchange, therapeutic plasma exchange, multi-tissue rejuvenation, rejuvenation by dilution


About Aging

Launched in 2009, Aging publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways.

Please visit our website at http://www.Aging-US.com or connect with us on:

Twitter - https://twitter.com/AgingJrnl
Facebook - https://www.facebook.com/AgingUS/
SoundCloud - https://soundcloud.com/aging-us
YouTube - https://www.youtube.com/agingus
LinkedIn -  https://www.linkedin.com/company/aging

Aging is published by Impact Journals, LLC please visit http://www.ImpactJournals.com or connect with @ImpactJrnls

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Trending with Impact: Multi-tissue Rejuvenation by Blood Plasma Exchange

Teach Me in 10

[url][link]www.pintofscience.com[/link][name]Pint of Science[/name][/url] is a non-profit organized entirely by a grass-roots community of thousands of scientists across the world. The festival holds events in more than 400 cities with 150000 attendees each May, allowing scientists to share their research with the public. Join this Teach Me in 10 session to hear Praveen Paul, the co-founder of Pint of Science, discuss how the festival was born and where she plans on taking it next.

What Is Pint of Science? With Praveen Paul

This installment of Teach Me in 10 features Dr Christopher Esk, a postdoctoral fellow at the Institute of Molecular Biotechnology in Vienna, Austria. In this episode of Teach Me in 10, Esk talks about the systematic analysis of human brain tissue development using cerebral organoids.

Brain Organoids With Dr Christopher Esk

This installment of Teach Me in 10 features Dr Carl May,  a postdoctoral research associate at The University of Bristol.

May is particularly interested in science communication and multimedia engagement and is the founder, producer and host of Keep it Renal, a podcast that aims to increase awareness of kidney disease. May has also launched Highway to Cell, an interactive science engagement portal dealing with all aspects of cellular biology. 

Watch this Teach Me in 10 to discover the importance of science communication and to Mays's hints, tips and tricks. 

Further resources: [url][link]https://soundcloud.com/carl-may-481661292/sets/keep-it-renal-podcast-1[/link][name]The Keep It Renal Podcast[/name][/url]

The Importance of Science Communication With Dr Carl May

Technology Networks

At the British Neuroscience Association's Festival of Neuroscience, Neuroscience News and Research spoke with brain organoid pioneer Madeline Lancaster. Dr Lancaster is a Group Leader at the MRC Laboratory of Molecular Biology in Cambridge.

The Birth of Brain Organoids With Dr Madeline Lancaster

REAL-TIME CELL ANALYSIS
The RESIPHER series of cell culture monitors are the world's first handheld devices to measure oxygen consumption in standard multi-well plates, providing continuous insight directly from your incubator.

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Monitor and analyze your data from anywhere with Lucid Lab - a cross-platform app for managing experiments, monitoring performance, and visualizing data. With our extensible open API, Lucid supports a variety of custom system integrations.  Gain insights into your experimental results remotely and rapidly iterate your experiment designs with your team in real-time.

TECHNOLOGY
To achieve its capabilities, RESIPHER incorporates multiple innovations. Key among these are an array of ultra-sensitive dissolved oxygen sensors developed by Lucid, along with dynamic vertical micro-movements that scan the oxygen gradient formed by metabolically active cells. These innovations give researchers insights into dynamic cellular responses never before seen.

CONFIGURABLE SYSTEMS
RESIPHER systems are currently available in 4-channel and 32-channel formats. With up to 8 devices on a single hub, the RESIPHER can meet the needs of any lab, big or small.  Sensing lids arrive sterilized and calibrated and are compatible with standard 96-well plates including Nunc, Falcon, and Greiner.

COLLABORATE
Lucid Lab's public platform (pub.lucidsci.com) provides a space for exploring shared experiment data, while the private space (lab.lucidsci.com) is the portal to your experiments both private and public.  At pub.lucidsci.com experiment data showing cell growth and drug dose response are featured. Additional showcase experiments are added continuously as they are performed.

Non-Invasive & Real-Time Cell Analysis on Standard Well Plates Directly in Your Incubator

3D cell culture has gained rapid adoption in recent years and it’s no wonder with the many benefits these more physiologically relevant models can deliver. There are several ways you can create a 3D model, but it depends on what the goals of your study are. Join this “Teach Me in 10” session to hear Corning Life Sciences application scientists walk you through common research goals and the most suitable 3D cell culture solutions for each.

How To Choose Your Tools for 3D Cell Culture With Audrey Bergeron and Hilary Sherman

This installment of Teach Me in 10 features [url][link]https://www.cardiff.ac.uk/people/view/81217-lelos-mariah[/link][name]Dr Mariah Lelos[/name][/url], a senior lecturer at Cardiff University. Dr Lelos teaches Cellular and Molecular Biology modules at Master's level at the university. Her particular interest is in  understanding the manifestation of motor and non-motor (cognitive, neuropsychiatric) dysfunctions in degenerative diseases using lesion, viral vector and genetically modified rodent models. Watch this Teach Me in 10 to discover why stem cells are an emerging treatment for neurological diseases such as Parkinson's and Huntington's.

Stem Cells

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