Microbiology

Mutant library

Creative Biogene offers a series of analytical testing service for biopharmaceutics, pharmaceutics and clinic products. With leading-edge instruments and an excellent platform, our scientist team bring clients professional services with high quality results.

https://www.creative-biogene.com/services/analytical-testing-service.html

Analytical Testing Services

Oncotarget

Dr. Sridhar Mani from Medicine and Genetics of The Albert Einstein College of Medicine, Bronx, NY, details his editorial published by Oncotarget in Volume 11, Issue 19, entitled, “Microbial metabolite mimicry: one step closer to drug discovery.”

DOI - https://doi.org/10.18632/oncotarget.27591

Correspondence to - Sridhar Mani - sridhar.mani@einsteinmed.org

Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.27591

Keywords - microbial metabolites, inflammation, IBD, mimicry, drugs

About Oncotarget

Oncotarget is a peer-reviewed, open access biomedical journal covering research on all aspects of oncology.

To learn more about Oncotarget, please visit https://www.oncotarget.com or connect with:

SoundCloud - https://soundcloud.com/oncotarget
Facebook - https://www.facebook.com/Oncotarget/
Twitter - https://twitter.com/oncotarget
Instagram - https://www.instagram.com/oncotargetjrnl/
YouTube - https://www.youtube.com/c/OncotargetYouTube/
LinkedIn - https://www.linkedin.com/company/oncotarget
Pinterest - https://www.pinterest.com/oncotarget/
Reddit - https://www.reddit.com/user/Oncotarget/

Oncotarget is published by Impact Journals, LLC please visit https://www.ImpactJournals.com or connect with @ImpactJrnls

Media Contact
MEDIA@IMPACTJOURNALS.COM
18009220957

Author Insight: Microbial Metabolite Mimicry May Improve Drug Discovery

Oncotarget published this trending research perspective in Volume 12, Issue 25, entitled, "Cell fusion as a link between the SARS-CoV-2 spike protein, COVID-19 complications, and vaccine side effects" by Yuri Lazebnik, PhD., from Lerna Consulting, New Haven, CT.

Abstract:
A distinctive feature of the SARS-CoV-2 spike protein is its ability to efficiently fuse cells, thus producing syncytia found in COVID-19 patients. This commentary proposes how this ability enables spike to cause COVID-19 complications as well as side effects of COVID-19 vaccines, and suggests how these effects can be prevented.

Press release - https://www.oncotarget.com/news/pr/sars-cov-2-covid-19-vaccine-side-effects/

Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28088

DOI - https://doi.org/10.18632/oncotarget.28088

Full text - https://www.oncotarget.com/article/28088/text/

Correspondence to - Yuri Lazebnik - yuri@lernaconsulting.com

Keywords - cell fusion, thrombosis, neuropathy, cancer, vaccines

About Oncotarget

Oncotarget is a bi-weekly, peer-reviewed, open access biomedical journal covering research on all aspects of oncology.

To learn more about Oncotarget, please visit https://www.oncotarget.com or connect with:

SoundCloud - https://soundcloud.com/oncotarget
Facebook - https://www.facebook.com/Oncotarget/
Twitter - https://twitter.com/oncotarget
Instagram - https://www.instagram.com/oncotargetjrnl/
YouTube - https://www.youtube.com/c/OncotargetYouTube/
LinkedIn - https://www.linkedin.com/company/oncotarget
Pinterest - https://www.pinterest.com/oncotarget/
Reddit - https://www.reddit.com/user/Oncotarget/

Oncotarget is published by Impact Journals, LLC please visit https://www.ImpactJournals.com or connect with @ImpactJrnls

Media Contact
MEDIA@IMPACTJOURNALS.COM
18009220957

Trending With Impact: Negative Effects of the Spike Protein in SARS-CoV-2 and Some Vaccines

Analytical Cannabis 

Speaking at The Science of Cannabis Cultivation Online Symposium in December 2021, Rachel Backer, PhD, Research & Development Specialist at BZAM Cannabis discussed microbial biostimulants.
Abstract: Plants are always associated with a microbial community that play essential roles in plant health and responses to environmental changes – cannabis is, of course, no exception. The interactions, and molecular signal exchange that occurs between plants their microbiome regulates plant responses to biotic (pathogen) and abiotic (salinity, heat, drought, etc.) stresses. Recent research in other plant species has highlighted that the application of microbial biostimulants (beneficial microbes, or compounds they excrete) can improve crop yields, particularly in stressful growing environments. While the cannabis microbiome has been explored in a few scientific publications, our knowledge in this area is much smaller than for other cultivated plants. Even fewer studies have examined the effects biostimulants on cannabis yield and cannabinoid/terpene profiles. In this talk, we will explore 1) the concept of the holobiont (the plant plus its microbiome), 2) how the plant microbiome contributes to plant stress and disease resistance, 3) what is known about cannabis response to application of microbial biostimulants, and 4) how novel microbial biostimulants can be developed and tested for efficacy in cannabis.

Leveraging Microbial Biostimulants to Improve Cannabis Yield and Quality

CD Genomics

CD Genomics is committed to providing novel NGS services enabling researchers to explore structure and function of the microbial community in a high-resolution and culture-independent manner using technology from Illumina and PacBio. In addition, we also offer the service to sequence the genome of the individual cultured bacteria, fungi, phage or virus, whether do novo or re-sequencing.  https://www.cd-genomics.com/Microbial-Genomics.html

Microbial Genomics — CD Genomics

Creative Enzymes

Enzymes are essential for the sustainable growth and development of any form of life on the planet and act as biocatalysts in a variety of metabolic and biochemical reactions. Enzymes have been used as food preservatives for a long time. Nowadays, enzymes enable various food industries to improve the quality and stability of products while improving production efficiency. The potential applications of enzymes in the food industry include auxiliary extraction of nutrient compounds and improvement of concentration, yield, stability, and effective recovery, etc. The growing demand for sustainable food has strengthened the power to develop microbial enzymes. https://probiotic.creative-enzymes.com/

Enzymes in Food Industry

Oncotarget published this trending research paper on September 17, 2019, entitled, "Consuming cholera toxin counteracts age-associated obesity" by researchers from the Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA; Department of infectious Diseases and Pathology, Faculty of Veterinary Medicine, Aristotle University of Thessaloniki, Greece.

Abstract:
During the past forty years there has been an inexplicable increase in chronic inflammatory disorders, including obesity. One theory, the ‘hygiene hypothesis’, involves dysregulated immunity arising after too few beneficial early life microbe exposures. Indeed, earlier studies have shown that gut microbe-immune interactions contribute to smoldering inflammation, adiposity, and weight gain. Here we tested a safe and well-established microbe-based immune adjuvant to restore immune homeostasis and counteract inflammation-associated obesity in animal models. We found that consuming Vibrio cholerae exotoxin subunit B (ctB) was sufficient to inhibit age-associated obesogenic outcomes in wild type mice, including reduced crown-like structures (CLS) and granulomatous necrosis histopathology in fat depots. Administration of cholera toxin reduced weight gain irrespective of age during administration; however, exposure during youth imparted greater slenderizing effects when compared with animals receiving ctB for the first time during adulthood. Beneficial effects were transplantable to other obesity-prone animals using immune cells alone, demonstrating an immune-mediated mechanism. Taken together, we concluded that oral vaccination with cholera toxin B helps stimulate health-protective immune responses that counteract age-associated obesity.

Press release - https://www.oncotarget.com/news/pr/consuming-cholera-toxin-counteracts-age-associated-obesity/

Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.27137

DOI - https://doi.org/10.18632/oncotarget.27137

Full text - https://www.oncotarget.com/article/27137/text/

Correspondence to - Susan E. Erdman - serdman@mit.edu

Keywords - body weight, mouse, exotoxin subunit B, CLS, inflammation

About Oncotarget

Oncotarget is a bi-weekly, peer-reviewed, open access biomedical journal covering research on all aspects of oncology.

To learn more about Oncotarget, please visit https://www.oncotarget.com or connect with:

SoundCloud - https://soundcloud.com/oncotarget
Facebook - https://www.facebook.com/Oncotarget/
Twitter - https://twitter.com/oncotarget
Instagram - https://www.instagram.com/oncotargetjrnl/
YouTube - https://www.youtube.com/c/OncotargetYouTube/
LinkedIn - https://www.linkedin.com/company/oncotarget
Pinterest - https://www.pinterest.com/oncotarget/
Reddit - https://www.reddit.com/user/Oncotarget/

Oncotarget is published by Impact Journals, LLC please visit https://www.ImpactJournals.com or connect with @ImpactJrnls

Media Contact
MEDIA@IMPACTJOURNALS.COM
18009220957

Paper Spotlight: The Cholera Toxin and Inflammation-associated Obesity

Oncotarget’s cover paper this week (Volume 12, Issue 26) is entitled, "Comparative transcriptome analysis between patient and endometrial cancer cell lines to determine common signaling pathways and markers linked to cancer progression," by researchers from the Department of Gynecologic Surgery & Obstetrics, Uniformed Services University of the Health Sciences, Bethesda, MD; Collaborative Health Initiative Research Program, Uniformed Services University of the Health Sciences, Bethesda, MD; National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD; Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, MD; National Institute on Minority Health and Health Disparities, National Institutes of Health, Bethesda, MD; Department of Anatomy, Physiology and Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD.

Abstract:
The rising incidence and mortality of endometrial cancer (EC) in the United States calls for an improved understanding of the disease's progression. Current methodologies for diagnosis and treatment rely on the use of cell lines as models for tumor biology. However, due to inherent heterogeneity and differential growing environments between cell lines and tumors, these comparative studies have found little parallels in molecular signatures. As a consequence, the development and discovery of preclinical models and reliable drug targets are delayed. In this study, we established transcriptome parallels between cell lines and tumors from The Cancer Genome Atlas (TCGA) with the use of optimized normalization methods. We identified genes and signaling pathways associated with regulating the transformation and progression of EC. Specifically, the LXR/RXR activation, neuroprotective role for THOP1 in Alzheimer’s disease, and glutamate receptor signaling pathways were observed to be mostly downregulated in advanced cancer stage. While some of these highlighted markers and signaling pathways are commonly found in the central nervous system (CNS), our results suggest a novel function of these genes in the periphery. Finally, our study underscores the value of implementing appropriate normalization methods in comparative studies to improve the identification of accurate and reliable markers.


Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28161

DOI - https://doi.org/10.18632/oncotarget.28161

Full text - https://www.oncotarget.com/article/28161/text/

Correspondence to - T. John Wu - twu@usuhs.edu

Keywords - endometrial cancer, cancer stage, comparative transcriptome analysis, signaling pathways, normalization

About Oncotarget

Oncotarget is a bi-weekly, peer-reviewed, open access biomedical journal covering research on all aspects of oncology.

To learn more about Oncotarget, please visit https://www.oncotarget.com or connect with:

SoundCloud - https://soundcloud.com/oncotarget
Facebook - https://www.facebook.com/Oncotarget/
Twitter - https://twitter.com/oncotarget
Instagram - https://www.instagram.com/oncotargetjrnl/
YouTube - https://www.youtube.com/c/OncotargetYouTube/
LinkedIn - https://www.linkedin.com/company/oncotarget
Pinterest - https://www.pinterest.com/oncotarget/
Reddit - https://www.reddit.com/user/Oncotarget/

Oncotarget is published by Impact Journals, LLC please visit https://www.ImpactJournals.com or connect with @ImpactJrnls

Media Contact
MEDIA@IMPACTJOURNALS.COM
18009220957

A Study on Biomarkers of Endometrial Cancer Progression

Aging (Aging-US)

Aging (Aging-US) published this trending research paper on July 16, 2020, entitled, "Activation of C-reactive protein proinflammatory phenotype in the blood retinal barrier in vitro: implications for age-related macular degeneration" by researchers from the Group of Ocular Inflammation, Clinical and Experimental Studies, Institut d’Investigacions Biomèdiques Agustí Pi i Sunyer (IDIBAPS), Hospital Clínic de Barcelona, Barcelona, Spain; Department of Life Sciences, Manchester Metropolitan University, Manchester, UK; Cardiovascular Research Center-ICCC, Hospital de la Santa Creu i Sant Pau, IIB-Sant Pau, CiberCV, Institute Carlos III, Barcelona, Spain; Academic Unit of Ophthalmology, School of Clinical Sciences and School of Cellular and Molecular Medicine, University of Bristol, Bristol, UK; National Institute for Health Research (NIHR) Biomedical Research Centre at Moorfields Eye Hospital and University College London Institute of Ophthalmology, London, UK.

Abstract:
The retinal pigment epithelium (RPE) is considered one of the main targets of age-related macular degeneration (AMD), the leading cause of irreversible vision loss among the ageing population worldwide. Persistent low grade inflammation and oxidative stress eventually lead to RPE dysfunction and disruption of the outer blood-retinal barrier (oBRB). Increased levels of circulating pentameric C-reactive protein (pCRP) are associated with higher risk of AMD. The monomeric form (mCRP) has been detected in drusen, the hallmark deposits associated with AMD, and we have found that mCRP induces oBRB disruption. However, it is unknown how mCRP is generated in the subretinal space. Using a Transwell model we found that both pCRP and mCRP can cross choroidal endothelial cells and reach the RPE in vitro and that mCRP, but not pCRP, is able to cross the RPE monolayer in ARPE-19 cells. Alternatively, mCRP can originate from the dissociation of pCRP in the surface of lipopolysaccharide-damaged RPE in both ARPE-19 and primary porcine RPE lines. In addition, we found that the proinflammatory phenotype of mCRP in the RPE depends on its topological localization. Together, our findings further support mCRP contribution to AMD progression enhancing oBRB disruption.

Special collection on eye disease - https://www.aging-us.com/special-collections-archive/eye-disease

Press release - https://www.aging-us.com/news_room/activation-of-c-reactive-protein-proinflammatory-phenotype-in-the-blood-retinal-barrier-in-vitro-implications-for-age-related-macular-degeneration

Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.103655

DOI - https://doi.org/10.18632/aging.103655

Full text - https://www.aging-us.com/article/103655/text

Correspondence to: Blanca Molins email: bmolins@clinic.cat

Keywords: age-related macular degeneration, retinal pigment epithelium, inflammation, C-reactive protein

About Aging-US

Launched in 2009, Aging-US publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging-US go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways.

Please visit our website at http://www.Aging-US.com​​ or connect with us on:

SoundCloud - https://soundcloud.com/Aging-Us
Facebook - https://www.facebook.com/AgingUS/
Twitter - https://twitter.com/AgingJrnl
Instagram - https://www.instagram.com/agingjrnl/
YouTube - https://www.youtube.com/agingus​
LinkedIn - https://www.linkedin.com/company/aging/
Pinterest - https://www.pinterest.com/AgingUS/

Aging-US is published by Impact Journals, LLC please visit http://www.ImpactJournals.com​​ or connect with @ImpactJrnls

Media Contact
18009220957
MEDIA@IMPACTJOURNALS.COM

Microbiology

Refine By

Keep up to date with all your favourite videos and channels.

Get personalised notifications on new releases and channel content by subscribing to the LabTube eNewsletter.