Mass Spectrometry

Shimadzu Analytical & Measuring

With unparalleled speed, sensitivity and spatial resolution, Shimadzu’s iMScope QT imaging mass microscope clears the
way to next-generation mass spectrometry imaging. It enables fast acquisition of high-mass, high-resolution images at the optical and molecular level, can simultaneously visualize and analyze samples, and offers full fusion with morphology studies. Integration with the Q-TOF LCMS-9030 enables obtaining distribution information and quantitative data for comprehensive analysis and it's easy to switch between MS imaging configuration and LCMS.

High-End Imaging with an Unequalled Combination of Speed, Sensitivity, and Resolution 

Teach Me in 10

March 8 marks [url][link]https://www.internationalwomensday.com/[/link][name]International Women’s Day 2023[/name][/url], a global holiday that celebrates women’s rights movements and brings focus to issues such as gender equality, reproductive rights and violence against women.

To celebrate International Women’s Day, Technology Networks is delighted to showcase the work of [url][link]https://pharmacy.auburn.edu/directory/angela-calderon.php[/link][name]Dr. Angela Calderón[/name][/url], associate professor in drug discovery and development at Auburn University in the United States.

At Auburn University, Dr. Calderón’s research interests lie in the application of mass spectrometry to study enzyme kinetics and ligand–enzyme interactions, particularly in the context of natural products drug discovery. Beyond the contributions her laboratory has made in botanical drug development, Dr. Calderón is also an advocate for women in science – recruiting only female scientists to her laboratory. She is also a passionate mentor for women in science, receiving the [url][link]https://ocm.auburn.edu/newsroom/campus_notices/2023/03/030847-calderon.php[/link][name]2023 Female Scientist Pharmacist Research Excellence Award[/name][/url] and the [url][link]https://pharmacy.auburn.edu/news/2020-21/120120-calderon-award.php[/link][name]2020 Provost Award for Faculty Excellence in Undergraduate Research Mentoring[/name][/url].

Join us for this Teach Me in 10 video to learn more about Dr. Calderón’s research and how she is championing efforts to support women in science and engineering roles.

Celebrating Female Scientists on International Women’s Day

This video offers a quick overview of the LCMS-9050 quadrupole Time-of-Flight (Q-TOF) mass spectrometer. 

Q-TOF LCMS-9050

Analytical Cannabis 

Speaking at the Analytical Cannabis Expo Europe Online 2022, Wendi Young delivered her talk on challenges in cannabinoid profile analysis of hemp extracts.

Challenges in Cannabinoid Profile Analysis of Hemp Extracts

Technology Networks

Speaking at ‘Advances in Proteomics & Metabolomics’ 2022, Harrison Specht from Northeastern University presented his talk on accessible single cell proteomics by mass spectroscopy.

Accessible Single Cell Proteomics by Mass Spectrometry

Does your vegan schnitzel taste slightly rancid or does your dairy product taste bitter? Does your food unpleasant, when you open the package? This is what chemists call an off-flavor.

This unpleasant effect is stronger with some products than with others, and this is because of the predominantly plant-based origin of the raw materials, which are subject to certain variations and can therefore cause an unpleasant taste. Food chemists need to be able to detect these substances at very low concentrations and find out if they are present in all or just in some products. 

In this episode, we are joined by Petra Gerhards, regional marketing manager for EMEA at Thermo Fisher Scientific. She explains how to detect small concentrations of off-flavors quickly with the Thermo Scientific™ Orbitrap™ MS technology which includes fully automated deconvolution. 

By watching this episode, you will learn about a fully automated workflow for Off Flavor analysis including sample preparation, High-Resolution Mass Spectrometry, Deconvolution and Principal Compound analysis.

Why Vegan Products Don’t Always Taste As You’d Expect

Chromatography & Mass Spectrometry Solutions

An LC-HRAM-MS method with Thermo Scientific™ TurboFlow™ online SPE was developed and validated for the quantitation of immunosuppressants. Online SPE efficiently extracts analytes while removing other components in a crude supernatant, significantly simplifying sample preparation. The use of full-scan data-dependent MS2 acquisition allows for high-resolution selected-ion monitoring quantitation of the analytes, confirming the analytes using MS2 fragmentation, as well as monitoring the signal intensities of major immunosuppressant metabolites.

A Therapeutic Drug Monitoring Assay of Immunosuppressants using TurboFlow LC and High-Resolution Mass Spectrometry

Detect an ever-increasing number of substances at ever-decreasing concentrations. The Thermo Scientific™ Tox Explorer™ Collection helps the world’s toxicology community in forensics, clinical research, employee drug testing, and sports anti-doping navigate with ease to solve complex analytical challenges and increase productivity. Tox Explorer Collection is an all-in-one toxicology solution. Incorporating the TSQ Quantis Plus mass spectrometer for drugs of abuse testing enables sensitive and reproducible analytical measurement needed for confirmation for compounds covering a range of compound classes and polarities.

Targeted Screening and Quantitation With a Tox Explorer Triple Quadrupole LC-MS Workflow

Ambient ionization mass spectrometry techniques that enable direct, gentle, and rapid analysis of samples offer exciting opportunities to provide clinicians with rich molecular data to enhance decision-making. Here, an overview of several ongoing clinical projects in the Eberlin laboratory related to the development of a handheld MS-based device, the MasSpec Pen technology, for improving patient care will be discussed. In particular, I will describe results centered around our efforts in employing the MasSpec Pen for intraoperative tissue analysis and cancer detection, identification of infectious microorganisms, and detection of drugs of abuse. Current challenges and opportunities towards incorporating this technology into clinical practice will also be addressed.

Mass Spectrometry

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