Mass Spectrometry

Bruker Mass Spectrometry

Heiko Neuweger, Ph.D., Director Bioinformatics SW R&D, Bruker Daltonics, discusses the new CCS-enabled workflows integrated into the MetaboScape software solution. Exploiting the additional dimension of ion mobility together with powerful acquisition modes such as PASEF expands the horizons of 4D-Metabolomics and 4D-Lipidomics research.

New CCS-enabled workflows in MetaboScape for 4D-Lipidomics and 4D-Metabolomics

Dr. Ansgar Korf, Software Developer, Software R&D Bioinformatics MetaboScape, Bruker Daltonics, introduces latest advances in the field of 4D-Lipidomics. The video covers optimized sensitivity for lipid analysis made possible by the combination of the new VIP-HESI source with the new timsTOF Pro 2. In addition, an update is given on novel CCS aware tools for lipid identification within MetaboScape software. These latest advances will mean any laboratory, can easily adopt 4D-Lipidomics workflows, whether they are novices or experts.

Advances in 4D-Lipidomics

SCIEX

Welcome to Zeno revolution driven by the combined power of the Zeno trap and electron activated dissociation (EAD).
A powerful leap in proprietary innovation, this high-resolution accurate mass system combines the power of Zeno trap pulsing with EAD fragmentation technology (electron activated dissociation) to uncover structural information, previously inaccessible, and drive the limits of quantification achievable with accurate mass further. 

•	Overcome QTOF MS/MS duty cycle deficiencies
>90% ions injected into the TOF
•	Sensitivity gains of up to 5-20X with Zeno trap pulsing 
Identify and quantify low abundance species
•	Tuneable fragmentation of all molecule types
Utilize controlled electron activated dissociation (EAD) 
•	MS/MS scan rates of up to 133Hz 
Improved DDA and High resolution MRM (MRMRHR)

Now, you can be extraordinary. Learn more at sciex.com/zenorevolution

Welcome to the Zeno Revolution: Introducing the ZenoTOF 7600 System

Mass spectrometric proteomics has become a staple of modern research in understanding biological function and disease mechanisms. Healthy or diseased tissues that seem homogenous are composed of cells with a variety of different proteomes. Deciphering the proteome of each single cell is key to fully understanding its function and has traditionally presented a major challenge.

timsTOF SCP - Expanding the Horizons of Single Cell Research

Watch the video on PaSER 2022, Beyond “Run & Done” with Dr. Chris Adams, Business Development Director Global Bioinformatics at Bruker Daltonics during their eXceed Symposia on "Expanding the Horizons of Single Cell Research"

PaSER: parallel database search engine in real-time, a GPU based informatics platform - "Run & Done"

The first new introduction is the timsTOF Pro 2 which is the next generation of our timsTOF Pro. It features ultimate robustness for large scale applications and is equipped with a new TIMS cell and three times higher ion capacity. The timsTOF Pro 2 can be considered the ideal partner for 4D-proteomics, lipidomics, metabolomics and biopharma applications such as HCP and MAM and offers extremely high performance for applications where robustness and throughput are also required.

Update from Heiner Koch, Ph.D., at Bruker Daltonik GmbH, on the timsTOF platform.

Gary Kruppa, Ph.D., Vice President, Proteomics, Bruker Daltonics, briefly discusses new 4D-Proteomics products launched by Bruker and their impact on performance of proteomics and biology research, including the timsTOF Pro 2 and timsTOF SCP.  The video briefly describes the  performance and features of these products that will have a high impact on proteomics research and expand the horizons of single cell research.

Innovations in 4D-Proteomics, Epiproteomics and Plasma Proteomics

Webinars by Technology Networks 

Webinar Summary
T cells mediate the classic immune response to viral infections and appear to play these roles in fighting COVID-19 and clearing SARS-CoV-2. In addition to killing virally infected cells, T cells direct the production of high-affinity and neutralizing antibodies. In other viral illnesses, T-cell immunity provides long-term, durable protection and blocks forward transmission; protective immunity decreases the symptom severity of subsequent infection.

The goal of vaccination is to mimic the protective immunity from natural infection with lower risk. The mRNA Emergency Use Authorization (EUA) vaccines have shown high levels of protection against symptomatic COVID-19 for at least six months. The SARS-CoV-2 variants are concerning, and appear to evade antibody immunity, but perhaps not T-cell immunity. The prospect that T cell-directed vaccines may protect against variants has scientists racing to develop broadly protective vaccines ahead of the rapidly evolving mutants.

Attendees will learn how:

T cells (helper and killer) work in tandem to control and clear the ongoing infection
T cells recognize and eliminate SARS-CoV-2 infected cells
Vaccines can elicit T-cell immune responses

T-Cell Immunity and COVID-19

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Mass Spectrometry

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