Informatics

Teach Me in 10

Scared of coding? Fear not, we've got the solution for you. In this installment of Teach Me in 10, we're joined by James Blackshaw, scientific data engineer at the EMBL-EBI. Blackshaw explains how a little coding can save a bench scientist a whole lot of time, and provides some useful tips and tricks to get you started.

Coding for Bench Scientists With James Blackshaw

Wyss Institute for Biologically Inspired Engineering at Harvard University

Using Human Organ Chips, researchers at the Wyss Institute were able to generate the mucus layer of the colon in vitro, which has never been done before. In the colon, the mucus layer protects intestinal epithelial cells against inflammatory stimuli such as pathogens, damaged cells, or irritants. The ability to support mucus-producing cells is one step towards modeling inflammatory bowel diseases in vitro.
 
For more information, please visit: https://wyss.harvard.edu/news/investigating-the-human-intestinal-mucus-barrier-up-close-and-personal/
 
Credit: Wyss Institute at Harvard University

Mucus Layer In Vitro on Human Colon Chip

For this installment of Teach Me in 10, we are joined by Gareth Walkom, the founder of withVR.  Gareth develops virtual reality tools for speech disorders, speech and language pathologists and researchers. Since 2015 he has been researching how virtual reality can be used within stuttering, exploring how virtual reality speaking situations can be used as a powerful tool. 

In this Teach Me in 10 video, Gareth explains more about speech disorders, how virtual reality is helping and the applications of such work.

Virtual Reality and Speech Disorders With Gareth Walkom

Aging

Aging published this research paper on March 14, 2021, entitled, “Deep longitudinal phenotyping of wearable sensor data reveals independent markers of longevity, stress, and resilience,” by researchers from Gero PTE. LTD., Singapore 409051, Singapore and Moscow Institute of Physics and Technology, Moscow Region 141700, Russia.

Abstract:
Biological age acceleration (BAA) models based on blood tests or DNA methylation emerge as a de facto standard for quantitative characterizations of the aging process. We demonstrate that deep neural networks trained to predict morbidity risk from wearable sensor data can provide a high-quality and cheap alternative for BAA determination. The GeroSense BAA model was trained and validated using steps per minute recordings from 103,830 one-week long and 2,599 of up to 2 years-long longitudinal samples and exhibited a superior association with life-expectancy over the average number of steps per day in, e.g., groups stratified by professional occupations. The association between the BAA and effects of lifestyles, the prevalence of future incidence of diseases was comparable to that of BAA from models based on blood test results. Wearable sensors let sampling of BAA fluctuations at time scales corresponding to days and weeks and revealed the divergence of organism state recovery time (resilience) as a function of chronological age. The number of individuals suffering from the lack of resilience increased exponentially with age at a rate compatible with Gompertz mortality law. We speculate that due to the stochastic character of BAA fluctuations, its mean and auto-correlation properties together comprise the minimum set of biomarkers of aging in humans.

To date, this study has generated an Altmetric Attention Score of 43. The Altmetric Attention Score provides an at-a-glance indication of the volume and type of online attention the research has received. 

Top Aging publications rated by Altmetric Attention Score -  https://www.aging-us.com/news_room/altmetric

Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.202816

DOI - https://doi.org/10.18632/aging.202816

Full text - https://www.aging-us.com/article/202816/text

Correspondence to: Timothy V. Pyrkov email: tim.pyrkov@gero.ai and Peter O. Fedichev email: peter.fedichev@gero.ai

Keywords: biological age acceleration (BAA), public health, personalized interventions, Gompertz law, resilience, aging

About Aging

Launched in 2009, Aging publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways.

Please visit our website at http://www.Aging-US.com​​ or connect with us on:

Twitter - https://twitter.com/AgingJrnl​
Facebook - https://www.facebook.com/AgingUS/​
SoundCloud - https://soundcloud.com/aging-us​
YouTube - https://www.youtube.com/agingus​
LinkedIn -  https://www.linkedin.com/company/aging​

Aging is published by Impact Journals, LLC please visit http://www.ImpactJournals.com​​ or connect with @ImpactJrnls

Media Contact
18009220957
MEDIA@IMPACTJOURNALS.COM

Top-Performer: Wearable Sensors Reveal Biological Markers of Longevity, Stress, Resilience

Bruker Mass Spectrometry

Watch the video on PaSER 2022, Beyond “Run & Done” with Dr. Chris Adams, Business Development Director Global Bioinformatics at Bruker Daltonics during their eXceed Symposia on "Expanding the Horizons of Single Cell Research"

PaSER: parallel database search engine in real-time, a GPU based informatics platform - "Run & Done"

Shimadzu Analytical & Measuring

Shimadzu’s LabSolutions Unified Laboratory Management System (ULMS) provides a single, easy-to-use interface for multiple types of techniques, including HPLC, LC-MS, GC, ICP-MS, FTIR, and UV-Vis.  It provides extremely efficient laboratory workflows while still providing the high-level functionality and data management required in today's modern laboratory. The unified platform simplifies training, facilitates better data management, and reduces costs.

How a Unified Laboratory Management System Streamlines Your Analysis

CD Genomics

CD Genomics is offering five platforms for genome-wide epigenomics analysis, each designed to accommodate a wide range of sample types and suit your specific research needs, allowing researchers to look at epigenetic alterations easily. This information will help us not only understand the role of DNA methylation but also identify targets for therapeutic treatment. https://www.cd-genomics.com/Epigenomics.html

Epigenetic Modifications and Epigenomic Technologies

Be Extraordinary

Join forces to share the future of science. Be part of a movement shining a light on identity, opportunity and inclusion.

As scientists, we are the very experts in discovering answers, but by missing out on invaluable, diverse perspectives, we’re missing out on crucial thinking that has the potential to unlock a new era of scientific greatness.

Introducing Grace, a young girl with an extraordinary future. Grace represents the next generation of scientists, but also, the underrepresented. She has the potential to change the face of analytical science; hers is an incredible, but fragile journey that calls upon your unique expertise for mentorship.

Grace will face many barriers as she grows up, but is unprepared for the challenges along the way, finding herself frequently asking a life-defining question:

“Should I continue with a career in science?”

By sharing your unique perspective and experiences with Grace, you’ll be joining an unprecedented conversation in science, where together, we can form an extensive, truly accurate picture of our industry.

Now, wouldn’t that be extraordinary.

INSPIRE GRACE and TAKE THE SURVEY: https://sciex.com/grace-csm
#BeExtraordinary #ExtraordinaryGrace

SCIEX presents Extraordinary Grace

Chromatography & Mass Spectrometry Solutions

Thermo Scientific Chromeleon CDS is built for compliance from the ground up. Learn how Chromeleon software makes it easier to comply with regulations and ensure data integrity in your laboratory.

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