Immunology

Teach Me in 10

What can integrative structural biology bring to viral research? In the last year we have seen viral research hit the spotlight as the world has battled against the SARS-CoV-2 virus. It has emphasized how critically important it is for us to be able to study what viruses look like, how they are structured and how they behave in order to develop diagnostic tests, therapeutics and preventives. Integrative structural biology methods are really key here, as explained by our Teach Me in 10 guest, Dr Albert Konijnenberg.

Structural Biology Goes Viral With Dr Albert Konijnenberg

More than one in ten individuals suffer from side effects after receiving COVID-19 vaccinations, including tenderness, pain, warmth, itching or bruising at the injection site, and tiredness, chills, joint pain and nausea. These side effects are not a sign of the disease; COVID-19 vaccines cannot infect anyone with SARS-CoV-2. In which case, what is causing the side effects? Professor Martin Michaelis and Dr Mark Wass of University of Kent’s School of Biosciences explain in this week's installment of Teach Me in 10.

Why Do COVID-19 Vaccines Cause Side Effects?

Technology Networks

Several European countries have temporarily halted the administration of the Oxford/AstraZeneca COVID-19 vaccine, ChAdOx1, after reports of thrombotic events occurring in individuals that had previously received the vaccine. In this video interview, we speak with Dr Andrew Preston, reader in Microbial Pathogenesis at the University of Bath, to learn more about the situation and its potential implications for global vaccination strategies. Visit the Technology Networks COVID-19 vaccine [url][link]https://www.technologynetworks.com/biopharma/articles/keep-up-to-date-with-covid-19-vaccine-development-333016[/link][name]hub page[/name][/url]
to keep up to date with the latest vaccine news.

Oxford/AstraZeneca COVID-19 Vaccination Pause: What's the Story?

In this installment of Teach Me in 10, we're joined by Matt Cooper, co-founder and chief scientific officer at Wugen, Inc. He is also assistant professor of medicine at Washington University. Matt discusses what T cells are and how they can be engineered to recognize cancer cells. This can be achieved by incorporating a specific receptor – the chimeric antigen receptor (CAR) – which results in the generation of CAR T cells. “CAR T cells are essentially a living targeted drug,” says Matt. Learn more about the key challenges related to engineering CAR T cells, discover ways to enable the broader application of these cells and hear about the development of allogeneic CAR T cells as an “off-the-shelf” treatment for cancer. You can learn more about CAR T cells by checking out the following content: [url][link]https://www.technologynetworks.com/cancer-research/lists/treating-cancer-5-types-of-immunotherapy-327728[/link][name]Treating Cancer – 5 Types of Immunotherapy[/name][/url], [url][link]https://www.technologynetworks.com/cancer-research/podcasts/opinionated-science-episode-14-cancer-immunotherapy-vaccines-viruses-and-nobel-prizes-340857[/link][name]Opinionated Science Episode 14: Cancer Immunotherapy: Vaccines, Viruses and Nobel Prizes[/name][/url] and [url][link]https://www.technologynetworks.com/cancer-research/infographics/cancer-and-the-immune-system-331284[/link][name]Cancer and the Immune System[/name][/url].

CAR T Cells: A Living Targeted Drug, With Dr Matt Cooper

Creative Biolabs

T-cell redirecting therapies with gene-engineered CAR T-cells and T-cell engaging bispecific antibodies (bsAb) are showing promising results in clinical trials. To guide precision immunotherapy, other factors should also be taken into consideration, including greater availability of immune targets and compounds with different modes of action during the development of new biomarkers, and determinants of response and resistance to a specific regimen.
https://www.creative-biolabs.com/bsab/new-ways-of-evaluating-the-tumor-immune-microenvironment-from-bench-to-bedside.htm

Immunotherapies and Tumor Immune Microenvironment

The severity and emergency of SARS-CoV-2 infection spurs an urgent need for antiviral drug and vaccine discovery. Creative Biolabs has spent considerable efforts to provide scientific support and comprehensive services to promote the success of this combat. 
https://sars-cov-2.creative-biolabs.com/novel-coronavirus-sars-cov2.htm

SARS-CoV-2 Introduction-Creative Biolabs

Biotech Videos 

During the last decade, mRNA became increasingly recognized as a versatile tool for the development of new innovative therapeutics. Especially for vaccine development, mRNA is of outstanding interest and numerous clinical trials have been initiated. Strikingly, all of these studies have proven that large-scale GMP production of mRNA is feasible and concordantly report a favorable safety profile of mRNA vaccines.https://www.creative-biolabs.com/vaccine/mrna-cancer-vaccines.htm

mRNA Vaccines

Humanization is important for reducing the immunogenicity of monoclonal antibodies derived from xenogeneic sources (commonly rodent) and for improving their activation of the human immune system.https://www.creative-biolabs.com/antibody-humanization.html

Antibody humanization

Across the globe, we are seeing the rollout of a number of different vaccines that are designed to protect against COVID-19. In this installment of Teach Me in 10, we're joined by [url][link]https://www.tonixpharma.com/about/management-team[/link][name]Dr Seth Lederman[/name][/url], a physician, scientist and the CEO of Tonix Pharmaceuticals. Dr Lederman talks us through the main types of COVID-19 vaccines that are currently available, explaining the differences between  "traditional" vaccines and the "new-era" vaccines. If you'd like to learn more about the different types of COVID-19 vaccines, be sure to check out the following resources: 
[url][link]https://www.technologynetworks.com/biopharma/articles/keep-up-to-date-with-covid-19-vaccine-development-333016[/link][name]Stay Up-to-Date With COVID-19 Vaccine Development[/name][/url], [url][link]https://www.technologynetworks.com/biopharma/videos/can-covid-19-vaccines-prevent-viral-transmission-344860[/link][name]Can COVID-19 Vaccines Prevent Viral Transmission?[/name][/url], [url][link]https://www.technologynetworks.com/biopharma/videos/covid-19-vaccine-myths-debunked-343870[/link][name]COVID-19 Vaccine Myths – Debunked![/name][/url], [url][link]https://www.technologynetworks.com/biopharma/blog/looking-beyond-the-spike-protein-for-sars-cov-2-vaccine-design-341664[/link][name]Looking Beyond the Spike Protein for SARS-CoV-2 Vaccine Design[/name][/url].

Immunology

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