Proteomics and Metabolomics

Chromatography & Mass Spectrometry Solutions

Dr Joshua Coon of the University of Wisconsin-Madison discusses Lipidomics and small molecule characterization with the Thermo Scientific Orbitrap IQ-X Tribrid MS. Hear first-hand experience from an MS expert about how Real-Time Library Search improves confidence in identification, and how the sensitivity of the linear ion trap can improve detection of unknown compounds.

Small Molecule analysis and Lipidomics research on the Thermo Scientific Orbitrap IQ-X Tribrid MS

Dr Gary Patti, Washington University- St. Louis discusses Metabolomics and metabolites research and structural characterization of small molecules with the Thermo Scientific™ Orbitrap IQ-X™ Tribrid™ MS. Hear from a leader in the field how ultra-high resolution on an instrument dedicated for small molecules can improve your results.

Structural characterization of metabolites with the Thermo Scientific Orbitrap IQ-X Tribrid MS

Teach Me in 10

Proteomics data, which represent the current state of health in an individual are increasingly available and described in numerous published results. However, the depth of data still might be daunting to those who have not yet worked with it. 

This Teach Me in 10 will provide an overview and inspiration for obtaining and analyzing high-dimensional proteomic data, showing how proteomic data are readily accessible for exploratory data analysis and hypothesis testing to those who are already familiar with genomic analysis or traditional statistics in other scientific fields.

We will describe how proteomic datasets with thousands of protein measurements per sample, such as SomaScan, can be understood, compared, visualized and linked to genomic and other -omics data. We will also show examples of sample data and analyses, and rapid discovery of novel findings in COVID-19 and cardiovascular medicine.

Simple and Straightforward High-Throughput Proteomics Analysis With Michael A. Hinterberg

In the post-genomic era, the importance of proteomics in helping us to gain a greater understanding of disease is clear. In this Teach Me in 10, we are joined by Dr. Clare Paterson from SomaLogic. Dr. Paterson discusses the power of proteomics, exploring how proteomics has evolved from assessments of single analytes to sensitive, specific and high throughput technologies capable of generating a wealth of invaluable data.

We will discuss how proteomics technologies, such as SomaScan, have advanced the field to not only be a tool for biomarker discovery, but also allow acceleration of drug development, clinical trials and transforming precision medicine. 

Further information resources: 1. [url][link]https://somalogic.com/whitepaper/detection-of-low-abundance-serum-proteins-associated-with-prediabetes-for-predictive-and-prognostic-purposes/[/link][name]Diabetes[/name][/url] 2. [url][link]https://somalogic.com/whitepaper/circulating-protein-biomarkers-are-a-promising-avenue-for-predicting-patient-response-to-cancer-immunotherapies/[/link][name]Immunoncology[/name][/url] 3. [url][link]https://somalogic.com/whitepaper/cvd-whitepaper/[/link][name]Cardiovascular[/name][/url] 4. [url][link]https://somalogic.com/whitepaper/nash-whitepaper/[/link][name]NASH[/name][/url] 5. [url][link]https://somalogic.com/whitepaper/infectious-disease-whitepaper/[/link][name]COVID-19 and the SomaScan® Platform[/name][/url].

What Can Proteomics Teach Us About Disease? With Dr. Clare Paterson

Learn about the innovative features of the Thermo Scientific Vanquish Neo UHPLC system - the new standard in low-flow UHPLC

Thermo Scientific Vanquish Neo UHPLC System: The New Standard in Nano-, Capillary-, and Micro-flow LC

Creative Enzymes

In biochemistry, the substrate is a molecule upon which an enzyme acts. Enzymes catalyze chemical reactions involving the substrate(s). In the case of a single substrate, the substrate bonds with the enzyme active site, and an enzyme-substrate complex is formed. The substrate is transformed into one or more products, which are then released from the active site. The active site is then free to accept another substrate molecule. In the case of more than one substrate, these may bind in a particular order to the active site, before reacting together to produce products. https://www.creative-enzymes.com/service/Screening-Of-Substrates-Inhibitors-And-Other-Ligands_65.html

Screening of Substrates, Inhibitors, and Other Ligands

Creative Proteomics videos

Glycan microarray has become a sensitive and versatile approach for the analysis of glycosylation changes in complex biological samples. It can not only investigate glycan-GBPs binding but also provide kinetic analysis of glycan–protein interactions. Nowadays, this application has rapidly expanded and now achieves successful discrimination of selective interactions between glycans and, not only proteins, but also viruses, bacteria and eukaryotic cells, and most recently even live cell responses to immobilized glycans. Glycan microarray can be used to discover functional glycans, characterize glycan-processing enzymes, and detect pathogens for diagnosis. It is also suitable for monitoring multiple molecular interactions with biomolecules where glycans are involved, offering a large variety of bioassay options.

As one of the leading companies in the omics field with over years of experience in omics study, Creative Proteomics provides Glycan Microarray Assay customized to your needs. https://www.creative-proteomics.com/services/glycan-microarray-assay.htm

Glycan Microarray Assay — Creative Proteomics

Proteins are the critical players in molecular recognition at the core of all biological processes. They can interact with the other components of cells, such as small-molecule metabolites, nucleic acids, membranes, and other proteins to build supramolecular assemblies and elaborate molecular machines that perform all sorts of functions, from chemical catalysis and mechanical work to signaling and regulation. As one of the most important interactions, Protein-Protein Interactions have been studied widely. So far large scale protein-protein interactions have been identified, and all the generated data collected together in specialized databases, enables the creation of large protein interaction networks. https://www.creative-proteomics.com/services/protein-protein-interactions-analysis-service.htm

Techniques for Protein-Protein Interaction— Creative Proteomics

Label-free protein quantification is a mass spectrometry-based method for identifying and quantifying relative changes in two or more biological samples instead of using a stable isotope-containing compound to label proteins. There is no limit on the number of samples in label-free protein quantification and it’s in principle applicable to any kind of sample, including materials that cannot be directly metabolically. It is ideal for large-sample analyses in clinical screening or biomarker discovery experiments.   https://www.creative-proteomics.com/

Proteomics and Metabolomics

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