Proteomics and Metabolomics

Creative Proteomics videos

Stable isotope labeling using amino acids in cell culture (SILAC) is a powerful method based on mass spectrometry that identifies and quantifies relative differential changes in protein abundance. First used in quantitative proteomics in 2002, it provides accurate relative quantification without any chemical derivatization or manipulation.

https://www.creative-proteomics.com/

Stable Isotope Labeling

Label-free protein quantification is a mass spectrometry-based method for identifying and quantifying relative changes in two or more biological samples instead of using a stable isotope-containing compound to label proteins. There is no limit on the number of samples in label-free protein quantification and it’s in principle applicable to any kind of sample, including materials that cannot be directly metabolically. It is ideal for large-sample analyses in clinical screening or biomarker discovery experiments.   https://www.creative-proteomics.com/

Label-free Protein Quantification

iTRAQ (Isobaric tag for relative and absolute quantitation) was developed by Applied Biosystems Incorporation in 2004. iTRAQ is a isobaric labeling method to determine the amount of proteins from different sources in just one single experiment. The iTRAQ reagents available always are set of 4-plex and 8-plex mass tages that can be used to label and et quantitative information on up to 4 and 8 different samples in one experiment
https://www.creative-proteomics.com/

iTRAQ-based Proteomics Approaches

Equipped with advanced tandem mass spectrometry for determination of lipid composition, powerful bioinformatic analytic systems, and a panel of experienced scientists and technicians, Creative Proteomics provide customer-tailored service with rapid analysis procedures and easy to read report, to speed up your scientific research.
https://www.creative-proteomics.com/services/targeted-lipidomics.htm

Mass Spectrometry Based Lipidomics at Creative Proteomics

Creative Proteomics has established a highly sensitive HPLC-MS/MS pipeline that can analyze N- and O-methylation in both eukaryotic and prokaryotic organisms. In addition, we have optimized our protocol, to enable more fast and sensitive site mapping service for methylation analysis.

https://www.creative-proteomics.com/services/Methylation.htm

Protein Methylation Analysis

SILAC-based quantitative proteomics (SILAQ) is an innovative technology used in high throughput quantitative analysis of large protein complexes, protein-protein and protein-small molecule interactions. https://www.creative-proteomics.com/Services/SILAC-based-proteomics-analysis.htm

SILAQ

Teach Me in 10

Getting your first work position after completing your PhD can be a daunting process. That's why we're delighted to be joined by Dr Adeayo Sotayo – who has some extremely helpful tips and tricks to aid you through the process – for this instalment of Teach Me in 10. Dr Sotayo is a Research Fellow in Design and Engineering at Brunel University London, with interests in writing, speaking and personal development. He runs a blog – www.drsotayo.com –where he shares his academic, work and professional experiences to inspire and motivate young people, students and researchers. You can also connect with him on Twitter (@drsotayo). Dr Sotayo covers various topics, such as how to publish and present your research, how to apply for grants, make the most of any opportunity that comes your way, and how to construct a compelling CV and cover letter.

Teach Me in 10 – Getting Your First Post-PhD Position in Academia With Dr Adeayo Sotayo

NanoTemper

Learn what attributes Prometheus users considered a must-have and how we made sure to preserve them when integrating and implementing new biophysical techniques. Prometheus Panta gives you the ability to simultaneously collect particle sizing, thermal unfolding, and aggregation data throughout the entire thermal ramp — making it the perfect tool for stability characterization of biologics.

Prometheus Panta adds DLS to the new gold standard for challenging stability characterization

Visit NanoTemper headquarters with Matthias Molnar, the Monolith Product Manager and meet the team who put their brains together to create the new Monolith. The new instrument combines the accuracy and sensitivity of original Monolith NT.115 instruments with the benefits of simpler and faster assay development, shorter run times, increased flexibility, and higher throughput. It's been completely re-designed for better usability and for greater precision and reproducibility of measurement data.

Proteomics and Metabolomics

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