Personalized Medicine

Aging (Aging-US)

Aging-US published this editorial on March 1, 2023 in Volume 15, Issue 5, entitled, "Parsing chronological and biological age effects on vaccine responses" by Chris P. Verschoor and George A. Kuchel from Health Sciences North Research Institute, Sudbury, Ontario, Canada.

DOI - https://doi.org/10.18632/aging.204572 (PDF Download)

Corresponding author - Chris P. Verschoor: cverschoor@hsnri.ca

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Keywords - aging, biological age, frailty, vaccination, influenza

About Aging-US

Launched in 2009, Aging-US publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging-US go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways.

Please visit our website at https://www.Aging-US.com​​ and connect with us:

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Parsing Chronological and Biological Age Effects on Vaccine Responses

Aging-US published this research paper as the cover for Volume 15, Issue 3, entitled, "Immune-mediated platelet depletion augments Alzheimer’s disease neuropathological hallmarks in APP-PS1 mice" by researchers from Institute of Molecular Regenerative Medicine, Paracelsus Medical University, Salzburg, Austria, Spinal Cord Injury and Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria, Institute of Experimental Neuroregeneration, Paracelsus Medical University, Salzburg, Austria, Department of Transfusion Medicine, University Clinic, Paracelsus Medical University, Salzburg, Austria, Austrian Cluster for Tissue Regeneration, Vienna, Austria.

DOI - https://doi.org/10.18632/aging.204502

Corresponding author - Kathrin Maria Kniewallner - kathrin.drerup@pmu.ac.at 

Abstract

In Alzheimer’s disease (AD), platelets become dysfunctional and might contribute to amyloid beta deposition. Here, we depleted platelets in one-year-old APP Swedish PS1 dE9 (APP-PS1) transgenic mice for five days, using intraperitoneal injections of an anti-CD42b antibody, and assessed changes in cerebral amyloidosis, plaque-associated neuritic dystrophy and gliosis. In APP-PS1 female mice, platelet depletion shifted amyloid plaque size distribution towards bigger plaques and increased neuritic dystrophy in the hippocampus. In platelet-depleted females, plaque-associated Iba1+ microglia had lower amounts of fibrillar amyloid beta cargo and GFAP+ astrocytic processes showed a higher overlap with thioflavin S+ amyloid plaques. In contrast to the popular hypothesis that platelets foster plaque pathology, our data suggest that platelets might limit plaque growth and attenuate plaque-related neuritic dystrophy at advanced stages of amyloid plaque pathology in APP-PS1 female mice. Whether the changes in amyloid plaque pathology are due to a direct effect on amyloid beta deposition or are a consequence of altered glial function needs to be further elucidated.

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Keywords - Alzheimer’s disease, platelets, amyloid-beta, microglia, astrocytes

About Aging-US

Launched in 2009, Aging-US publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging-US go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways.

Please visit our website at https://www.Aging-US.com​​ and connect with us:

SoundCloud - https://soundcloud.com/Aging-Us
Facebook - https://www.facebook.com/AgingUS/
Twitter - https://twitter.com/AgingJrnl
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Platelet Depletion Augments Alzheimer’s Disease Neuropathological Hallmarks

Teach Me in 10

Oligonucleotide therapeutics have attracted much attention recently. They represent an up-and-coming class of therapeutic options that can lead to major advances in the treatment or cure of diseases, holding great potential for further development in human medicine. 

In this Teach me in 10 we are joined by Chris Rosenau, product manager of nucleic acid therapeutics at Thermo Fisher Scientific. He covers the basics of oligonucleotide therapeutics, their trends and challenges, considerations for phosphoramdites in oligonucleotide synthesis, and resources from Thermo Fisher Scientific that are available to you in oligonucleotide therapeutic development.

What Are Oligonucleotide Therapeutics?

Analytical Cannabis 

Speaking at the Analytical Cannabis Expo Europe Online 2022, Oliver Zugel delivered his talk on the cannabis industry in Germany.

Will Germany Be the Turning Point for a Troubled Cannabis Industry?

Speaking at the Analytical Cannabis Expo Europe Online 2022, Alex Fray discussed the regulatory roadmap for medicinal cannabis in Europe.

Medicinal Cannabis in Europe – A Regulatory Roadmap

Speaking at the Analytical Cannabis Expo Europe Online 2022, Russ Hudson delivered his talk on the state of the cannabis market in Spain.

State of Cannabis Market in Spain

Oncotarget

Oncotarget published this research paper in Volume 14, entitled, “The chromatographic constitution of andiroba oil and its healing effects, compared to the LLLT outcomes, in oral mucositis induced in golden Syrian hamsters: a new treatment option" by the researchers from the Department of Dentistry, Federal University of Pará, Guamá, Belém, Pará 66075-970, Brazil; Department of Medicine, University Center of Pará, Souza, Belém, Pará 66613-903, Brazil; Department of Genetics, Laboratory of Human Cytogenetics, Federal University of Pará, Guamá, Belém, Pará 66075-970, Brazil.

DOI - https://doi.org/10.18632/oncotarget.28338

Correspondence to - Diego D.F.A. Alcantara - diegoalcantara@globo.com 

Abstract

The oral mucositis is a mucosal alteration that usually arises from oncological treatments, such as chemotherapy, and it is characterized as an inflammatory process. The aim of this study is to demonstrate the chromatographic constitution of Andiroba oil, comparing and evaluating Andiroba oil and laser scarring efficiency in treatments of oral mucositis in hamsters. These animals were submitted to 5-Fluorouracil. A total of 122 animals were used, randomized and divided into the following groups: (a) positive control; (b) laser associated to andiroba oil; (c) laser; (d) andiroba oil; (e) negative control; (f) cyclophosphamide (genotoxicity control). The induction of oral mucositis occurred by the administration of intraperitoneal Fluorouracila (60 mg/kg) and trauma to the mucosa. The laser protocol was performed once a day and the andiroba oil applied 3 times a day (1,5 ml/day). The mucosae were photographed and removed for clinical and histopathological analysis on day 4, 8, 12 and 15. The analysis was based in OM severity, in specific scoring for the clinical and histopathological aspect. Toxicity was evaluated on day 15 using comet assay and it was performed by variant DNA damage parameters. The data were analysed using analysis of variance (ANOVA) Tukey post-test and Kruskal–Wallis Dunn post-test. The “andiroba oil” and “laser” groups presented better results when compared to the control groups and the treatment associations. The andiroba oil presented the best scarring results, even considering its efficiency proximity to the laser treatment. Andiroba and laser, separately, did not present genotoxicity, however their association evidences damage to DNA.

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Keywords - phytotherapeutic drugs, medical oncology, stomatitis, wound healing, low-level light therapy

About Oncotarget

Oncotarget is a primarily oncology-focused, peer-reviewed, open access journal. Papers are published continuously within yearly volumes in their final and complete form, and then quickly released to Pubmed. On September 15, 2022, Oncotarget was accepted again for indexing by MEDLINE. Oncotarget is now indexed by Medline/PubMed and PMC/PubMed.

To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us:

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Healing Effects & Genotoxicity of Andiroba Oil vs LLLT for Oral Mucositis in Hamsters

Oncotarget published this editorial perspective in Volume 13, entitled, “The future of bioorthogonal-chemistry for targeting of exosomes in precision medicine" by Mujib Ullah from Institute for Immunity and Transplantation, Stem Cell Biology and Regenerative Medicine, School of Medicine, Stanford University, Palo Alto, CA; Molecular Medicine Department of Medicine, Stanford University, CA.

DOI - https://doi.org/10.18632/oncotarget.28323

Correspondence to - Mujib Ullah - ullah@stanford.edu 

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Keywords - precision medicine, bioorthogonal, exosomes

About Oncotarget

Oncotarget is a primarily oncology-focused, peer-reviewed, open access journal. Papers are published continuously within yearly volumes in their final and complete form, and then quickly released to Pubmed. On September 15, 2022, Oncotarget was accepted again for indexing by MEDLINE. Oncotarget is now indexed by Medline/PubMed and PMC/PubMed.

To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us:

SoundCloud - https://soundcloud.com/oncotarget
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18009220957

Future of Bioorthogonal-Chemistry for Targeting of Exosomes in Precision Medicine

Technology Networks

Speaking at the Vaccine Research & Development 2022 online symposium, Zoltan Kis from the University of Sheffield discussed digital design for RNA vaccine and therapeutic production.

Personalized Medicine

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