Neuroscience

Teach Me in 10

Research by a team of neuroscientists from the University of Nevada, Las Vegas (UNVL) has shown that it is possible to identify the molecular mechanisms underlying a host of adverse symptoms associated with unique subtypes of neurodevelopmental disorders. This work could one day improve the lives of millions of people worldwide.
Intellectual disability (ID) is a common neurodevelopmental disorder that can arise from genetic mutations ranging from trisomy to single nucleotide polymorphism. Trisomy of the 21st chromosome (Down syndrome) is the most common underlying cause of ID, but mutations in a growing number of single genes have been identified as causative in ID, including NONO and ARHGEF9. 

In this episode of Teach Me in 10, UNLV neuroscientist Dr. Rochelle Hines joins us to discuss the team’s latest findings, which show that mutations in ARHGEF9  — the gene that codes for collybistin — lead to ID through impaired α2 subunit function.

Want to learn more? Rochelle suggests you check out the following resources:  

https://www.nature.com/articles/s41380-022-01468-z
https://www.nature.com/articles/s41467-018-05481-1

Neurodevelopmental Disorders With Rochelle Hines

Aging (Aging-US)

BUFFALO, NY-March 28, 2022 – Impact Journals publishes scholarly journals in biomedical sciences with a focus on all areas of cancer and aging research. Impact Journals will be participating as an exhibitor at the American Association for Cancer Research (AACR) 2022 annual meeting from April 8-13, 2022, in New Orleans, Louisiana. This year, the AACR conference is entitled, “Decoding Cancer Complexity | Integrating Science | Transforming Patient Outcomes.”

Oncotarget and Aging (Aging-US) are Impact Journals’ two most prominent journals. Oncotarget is a peer-reviewed, open-access journal dedicated to publishing high-quality, primarily oncology-focused research—in a continuous format within ongoing yearly volumes. Aging is a twice-monthly, traditional, peer-reviewed, open-access journal covering all areas of research on aging, including age-related diseases such as cancer and COVID-19. 

Visit booth No. 2012 at the 2022 AACR annual meeting from April 8-13, 2022, to connect with members of the Impact Journals team. 

To learn more about Impact Journals, visit https://www.impactjournals.com/.

For media requests, please contact media@impactjournals.com.

Keywords - cancer, cancer research, open access, peer review, research papers, oncology, oncology research, journal publication, announcement, press release, meeting, conference, aging, longevity, healthspan, lifespan, lifestyle

About Aging-US

Launched in 2009, Aging-US publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging-US go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways.

Please visit our website at http://www.Aging-US.com​​ and connect with us:

SoundCloud - https://soundcloud.com/Aging-Us
Facebook - https://www.facebook.com/AgingUS/
Twitter - https://twitter.com/AgingJrnl
Instagram - https://www.instagram.com/agingjrnl/
YouTube - https://www.youtube.com/agingus​
LinkedIn - https://www.linkedin.com/company/aging/
Pinterest - https://www.pinterest.com/AgingUS/

Aging-US is published by Impact Journals, LLC: http://www.ImpactJournals.com​​

Media Contact
18009220957
MEDIA@IMPACTJOURNALS.COM

Announcement: Aging (Aging-US) at the 2022 AACR Annual Meeting

Have you ever wondered where a food’s flavor comes from? Most of us think it’s in food, but in reality, much of flavor has to do with our own personal perception of the food and how our brain interprets these signals when we’re eating. Yes, a significant part of flavor does include how certain molecules in a food either trigger our taste buds or receptors in our nasal cavity, but other aspects of flavor have much more to do with our own personal perception of the food such as our previous experiences with the food, memories, and emotions. So, what we know as “flavor” is actually a complex response to the physical and chemical “inputs” we experience when eating a food. This includes but is not limited to taste, aroma, color, texture, irritants, memories, emotions, and our personal experiences with the food. This week's Teach Me in 10 features Dr. Abbey Thiel, or "Abbey the Food Scientist", a postdoctoral researcher at Wageningen University with a focus in dairy foods and processing technologies. Dr. Thiel obtained her PhD in Food Science from the University of Wisconsin-Madison where she studied the microstructure of ice cream and whipped toppings. In her free time, Dr. Thiel runs a YouTube channel named [url][link]https://www.youtube.com/watch?v=y1kL90xqBuc&t=4s&ab_channel=AbbeytheFoodScientist[/link][name]“Abbey the Food Scientist”[/name][/url] where she breaks down everything related to Food Science.

Where Does a Food’s Flavor Come From? With Dr. Abbey Thiel

Aging (Aging-US) published this trending editorial in Volume 14, Issue 5, entitled, “Sex matters in Alzheimer’s disease?” by researchers Sheeja Navakkode, Toh Hean Ch’ng, and Sreedharan Sajikumar from the Department of Physiology, National University of Singapore.

DOI - https://doi.org/10.18632/aging.203950 (PDF Download)

Full text - https://www.aging-us.com/article/203950

Corresponding author - Sreedharan Sajikumar - phssks@nus.edu.sg

Keywords - Alzheimer's disease, LTP, behavioural tagging, sexual dimorphism, transcriptome profiling

About Aging-US

Launched in 2009, Aging-US publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging-US go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways.

Please visit our website at http://www.Aging-US.com​​ and connect with us:

SoundCloud - https://soundcloud.com/Aging-Us
Facebook - https://www.facebook.com/AgingUS/
Twitter - https://twitter.com/AgingJrnl
Instagram - https://www.instagram.com/agingjrnl/
YouTube - https://www.youtube.com/agingus​
LinkedIn - https://www.linkedin.com/company/aging/
Pinterest - https://www.pinterest.com/AgingUS/

Aging-US is published by Impact Journals, LLC: http://www.ImpactJournals.com​​

Media Contact
18009220957
MEDIA@IMPACTJOURNALS.COM

Trending With Impact: Alzheimer’s Disease Differs Between Men and Women

Analytical Cannabis 

Speaking at an Analytical Cannabis and Technology Networks webinar back in December 2021, Alex Kwan, Associate Professor at Yale University presented his talk on psychedelics and the neurobiology of fast-acting antidepressants.

Abstract: Depression is debilitating, yet treatment options are limited. Psychedelics have emerged as potentially impactful drugs with promise of long-lasting beneficial actions. As a result, there are growing efforts to optimize their use in the clinic and to develop next-generation psychedelics with improved pharmacological profiles. One major challenge, however, is that we still do not have a full understanding of how psychedelics work in the brain.

In this seminar, I will describe my lab’s work on fast-acting antidepressants. I will talk about experiments in animal models that have identified cell types and neural plasticity processes involved in ketamine and psilocybin’s actions. I will discuss how the biological insights may lead to novel circuit-level biomarkers, which are crucially needed to accelerate the search for new psychiatric drugs.

Psychedelics and the Neurobiology of Fast-acting Antidepressants

Aging (Aging-US) published this trending research paper as the cover for Volume 14, Issue 4 on February 27, 2022, entitled, “Mid-life epigenetic age, neuroimaging brain age, and cognitive function: coronary artery risk development in young adults (CARDIA) study” by researchers from the Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL; Biggs Institute Neuroimaging Core, Glenn Biggs Institute for Neurodegenerative Disorders, University of Texas Health Science Center at San Antonio, San Antonio, TX; Department of Radiology, University of Pennsylvania, Philadelphia, PA; Division of Cardiology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL; Feinberg Cardiovascular Research Institute, Northwestern University Feinberg School of Medicine, Chicago, IL; Department of Neurology, Boston University School of Medicine, Boston, MA; Laboratory of Epidemiology and Population Science, Intramural Research Program, National Institute on Aging, National Institutes of Health, Bethesda, MD; Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago; Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN; Departments of Neurological Surgery, Medicine-Hematology and Oncology, Microbiology-Immunology, Northwestern University Feinberg School of Medicine, Chicago, IL; Department of Environmental Health Sciences, Columbia University Mailman School of Public Health, New York, NY; Kaiser Permanente Division of Research, Oakland, CA; Department of Diagnostic Medicine, Dell Medical School, University of Texas at Austin, Austin, TX; Departments of Psychiatry and Behavioral Sciences, University of California, San Francisco, CA; Department of Neurology University of California, San Francisco, CA; Department of Epidemiology and Biostatistics, University of California San Francisco, CA; San Francisco VA Medical Center, San Francisco, CA.

DOI - https://doi.org/10.18632/aging.203918

Corresponding Authors - Yinan Zheng - y-zheng@northwestern.edu, Kristine Yaffe - Kristine.Yaffe@ucsf.edu, and Lifang Hou - l-hou@northwestern.edu

Abstract

The proportion of aging populations affected by dementia is increasing. There is an urgent need to identify biological aging markers in mid-life before symptoms of age-related dementia present for early intervention to delay the cognitive decline and the onset of dementia. In this cohort study involving 1,676 healthy participants (mean age 40) with up to 15 years of follow up, we evaluated the associations between cognitive function and two classes of novel biological aging markers: blood-based epigenetic aging and neuroimaging-based brain aging. Both accelerated epigenetic aging and brain aging were prospectively associated with worse cognitive outcomes. Specifically, every year faster epigenetic or brain aging was on average associated with 0.19-0.28 higher (worse) Stroop score, 0.04-0.05 lower (worse) RAVLT score, and 0.23-0.45 lower (worse) DSST (all false-discovery-rate-adjusted p <0.05). While epigenetic aging is a more stable biomarker with strong long-term predictive performance for cognitive function, brain aging biomarker may change more dynamically in temporal association with cognitive decline. The combined model using epigenetic and brain aging markers achieved the highest accuracy (AUC: 0.68, p<0.001) in predicting global cognitive function status. Accelerated epigenetic age and brain age at midlife may aid timely identification of individuals at risk for accelerated cognitive decline and promote the development of interventions to preserve optimal functioning across the lifespan.

Keywords - cognitive function, epigenetic age, brain age, DNA methylation, magnetic resonance imaging

About Aging-US

Launched in 2009, Aging-US publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging-US go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways.

Please visit our website at http://www.Aging-US.com​​ and connect with us:

SoundCloud - https://soundcloud.com/Aging-Us
Facebook - https://www.facebook.com/AgingUS/
Twitter - https://twitter.com/AgingJrnl
Instagram - https://www.instagram.com/agingjrnl/
YouTube - https://www.youtube.com/agingus​
LinkedIn - https://www.linkedin.com/company/aging/
Pinterest - https://www.pinterest.com/AgingUS/

Aging-US is published by Impact Journals, LLC: http://www.ImpactJournals.com​​

Media Contact
18009220957
MEDIA@IMPACTJOURNALS.COM

Mid-life Epigenetic Age, Brain Age and Cognitive Function in the CARDIA Cohort

Oncotarget

Oncotarget published this trending research paper on February 21, 2022 in Volume 13, entitled, "A liquid fraction of extracellular matrix inhibits glioma cell viability in vitro and in vivo" by researchers from the Department of Surgery, University of Pittsburgh, Pittsburgh, PA; McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA; Department of Biochemistry and Molecular Genetics, University of Colorado Denver, Aurora, CO; Animal Imaging Center, School of Medicine, University of Pittsburgh, Pittsburgh, PA; Department of Neurobiology, University of Pittsburgh, Pittsburgh, PA; Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA.

DOI - https://doi.org/10.18632/oncotarget.28203

Correspondence to - Stephen F. Badylak - badylaks@upmc.edu

Abstract

Suppressive effects of extracellular matrix (ECM) upon various cancers have been reported. Glioblastoma multiforme has poor prognosis and new therapies are desired. This work investigated the effects of a saline-soluble fraction of urinary bladder ECM (ECM-SF) upon glioma cells. Viability at 24 hours in 1, 5, or 10 mg/mL ECM-SF-spiked media was evaluated in primary glioma cells (0319, 1015, 1119), glioma cell lines (A172, T98G, U87MG, C6), and brain cell lines (HCN-2, HMC3). Viability universally decreased at 5 and 10 mg/mL with U87MG, HCN-2, and HCM3 being least sensitive. Apoptosis in 0319 and 1119 cells was confirmed via NucView 488. Bi-weekly intravenous injection of ECM-SF (120 mg/kg) for 10 weeks in Sprague-Dawley rats did not affect weight, temperature, complete blood count, or multi-organ histology (N = 5). Intratumoral injection of ECM-SF (10 uL of 30 mg/mL) at weeks 2–4 post C6 inoculation in Wistar rats increased median survival from 24.5 to 51 days (hazard ratio for death 0.22) and decreased average tumor volume at time of death from 349 mm3 to 90 mm3 over 10 weeks (N = 6). Mass spectrometry identified 2,562 protein species in ECM-SF, parent ECM, and originating tissue. These results demonstrate the suppressive effects of ECM on glioma and warrant further study.

Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28203

Keywords - extracellular matrix, brain cancer, glioma treatment, dynamic reciprocity, tissue organization field theory

About Oncotarget

Oncotarget is a peer-reviewed, open access biomedical journal covering research on all aspects of oncology.

To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us:

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LinkedIn - https://www.linkedin.com/company/oncotarget
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Reddit - https://www.reddit.com/user/Oncotarget/

Oncotarget is published by Impact Journals, LLC: https://www.ImpactJournals.com

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MEDIA@IMPACTJOURNALS.COM
18009220957

Trending With Impact: A Liquid Fraction of Extracellular Matrix Fights Gliomas

Aging (Aging-US) published this research paper in Volume 11, Issue 17, entitled, "Conclusions from a behavioral aging study on male and female F2 hybrid mice on age-related behavior, buoyancy in water-based tests, and an ethical method to assess lifespan" by researchers from the Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden; Discovery Biology, Discovery Sciences, R&D AstraZeneca, Gothenburg, Mölndal, Sweden; Department of Genetics, Paul F. Glenn Center for the Biology of Aging, Harvard Medical School, Boston, MA; Department of Neuroscience, Biomedicum, Karolinska Institutet, Stockholm, Sweden; Quantitative Biology, Discovery Sciences, R&D AstraZeneca, Cambridge, UK.

DOI - https://doi.org/10.18632/aging.102242

Corresponding Author - Malin Hernebring - malin.hernebring@gu.se

Abstract

Due to strain-specific behavioral idiosyncrasies, inbred mouse strains are suboptimal research models for behavioral aging studies. The aim of this study is to determine age-related behavioral changes of F2 hybrid C57BL/6NxBALB/c male and female mice. Lifespan was followed (nmales=48, nfemales=51) and cohorts of mature adult (7 months), middle-aged (15 months), and old mice (22 months of age; n=7-12 per group) were assessed regarding open-field activity, exploration, passive avoidance learning/memory, and depressive-like behavior. We found that both males and females demonstrated decreased exploratory behavior with age, while memory and depressive-like behavior were maintained. Females exhibited enhanced depressive-like behavior compared to males; however, a correlation between fat mass and swimming activity in the test directly accounted for 30-46% of this behavioral sex difference. In addition, we suggest a method to qualitatively estimate natural lifespan from survival analyses in which animals with signs of pain or severe disease are euthanized. This is, to our knowledge, the first behavioral study to consider both sex and aging in hybrid mice. We here define decreased exploratory behavior as a conserved hallmark of aging independent of sex, highlight the effect of buoyancy in water tests, and provide a method to assay lifespan with reduced animal suffering.

Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.102242

Press release - https://www.aging-us.com/news_room/conclusions-from-a-behavioral-aging-study-on-male-and-female-f2-hybrid-mice-on-age-related-behavior-buoyancy-in-water-based-tests-and-an-ethical-method-to-assess-lifespan

Keywords - F2 hybrid mice, aging, sex comparison, exploratory activity, water-based behavioral tests

About Aging-US

Launched in 2009, Aging-US publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging-US go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways.

Please visit our website at http://www.Aging-US.com​​ and connect with us:

SoundCloud - https://soundcloud.com/Aging-Us
Facebook - https://www.facebook.com/AgingUS/
Twitter - https://twitter.com/AgingJrnl
Instagram - https://www.instagram.com/agingjrnl/
YouTube - https://www.youtube.com/agingus​
LinkedIn - https://www.linkedin.com/company/aging/
Pinterest - https://www.pinterest.com/AgingUS/

Aging-US is published by Impact Journals, LLC: http://www.ImpactJournals.com​​

Media Contact
18009220957
MEDIA@IMPACTJOURNALS.COM

Paper Spotlight: A Behavioral Aging Study on Male and Female F2 Hybrid Mice

Aging (Aging-US) published this trending research paper in Volume 11, Issue 11, entitled, "Habitual tea drinking modulates brain efficiency: evidence from brain connectivity evaluation" by researchers from the Laboratory for Brain-Bionic Intelligence and Computational Neuroscience, Wuyi University, Jiangmen, China; Centre for Life Sciences, National University of Singapore, Singapore; School of Computer Science and Electronic Engineering, University of Essex, Colchester, United Kingdom; Brain Mapping Unit, Department of Psychiatry, University of Cambridge, Herchel Smith for Brain and Mind Sciences, Cambridge, United Kingdom; Department of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

DOI - https://doi.org/10.18632/aging.102023

Correspondence to - Junhua Li - junhua.li@essex.ac.uk and Lei Feng - pcmfl@nus.edu.sg

Abstract:
The majority of tea studies have relied on neuropsychological measures, and much fewer on neuroimaging measures, especially for interregional connections. To date, there has been no exploration of the effect of tea on system-level brain networks. We recruited healthy older participants to two groups according to their history of tea drinking frequency and investigated both functional and structural networks to reveal the role of tea drinking on brain organization. The results showed that tea drinking gave rise to the more efficient structural organization, but had no significant beneficial effect on the global functional organization. The suppression of hemispheric asymmetry in the structural connectivity network was observed as a result of tea drinking. We did not observe any significant effects of tea drinking on the hemispheric asymmetry of the functional connectivity network. In addition, functional connectivity strength within the default mode network (DMN) was greater for the tea-drinking group, and coexistence of increasing and decreasing connective strengths was observed in the structural connectivity of the DMN. Our study offers the first evidence of the positive contribution of tea drinking to brain structure and suggests a protective effect on age-related decline in brain organisation.

Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.102023

Press release - https://www.aging-us.com/news_room/habitual-tea-drinking-modulates-brain-efficiency-evidence-from-brain-connectivity-evaluation

Keywords - tea drinking, brain efficiency, fMRI, DTI, default mode network, hemispheric asymmetry, aging

About Aging-US

Launched in 2009, Aging-US publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging-US go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways.

Please visit our website at http://www.Aging-US.com​​ and connect with us:

SoundCloud - https://soundcloud.com/Aging-Us
Facebook - https://www.facebook.com/AgingUS/
Twitter - https://twitter.com/AgingJrnl
Instagram - https://www.instagram.com/agingjrnl/
YouTube - https://www.youtube.com/agingus​
LinkedIn - https://www.linkedin.com/company/aging/
Pinterest - https://www.pinterest.com/AgingUS/

Aging-US is published by Impact Journals, LLC: http://www.ImpactJournals.com​​

Media Contact
18009220957
MEDIA@IMPACTJOURNALS.COM

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