Neuroscience

Aging

This week's cover paper of Aging (Volume 13, Issue 14) is entitled, "Beneficial effects of dietary supplementation with green tea catechins and cocoa flavanols on aging-related regressive changes in the mouse neuromuscular system," by researchers from Universitat de Lleida and Institut de Recerca Biomèdica de Lleida (IRBLleida), Lleida, Spain; Universitat Autònoma de Barcelona and CIBERNED, Bellaterra, Spain; University of Granada, Granada, Spain; Abbott Nutrition, Research and Development, Columbus, OH; Abbott Nutrition, Research and Development, Granada, Spain.

Abstract:
Besides skeletal muscle wasting, sarcopenia entails morphological and molecular changes in distinct components of the neuromuscular system, including spinal cord motoneurons (MNs) and neuromuscular junctions (NMJs); moreover, noticeable microgliosis has also been observed around aged MNs. Here we examined the impact of two flavonoid-enriched diets containing either green tea extract (GTE) catechins or cocoa flavanols on age-associated regressive changes in the neuromuscular system of C57BL/6J mice. Compared to control mice, GTE- and cocoa-supplementation significantly improved the survival rate of mice, reduced the proportion of fibers with lipofuscin aggregates and central nuclei, and increased the density of satellite cells in skeletal muscles. Additionally, both supplements significantly augmented the number of innervated NMJs and their degree of maturity compared to controls. GTE, but not cocoa, prominently increased the density of VAChT and VGluT2 afferent synapses on MNs, which were lost in control aged spinal cords; conversely, cocoa, but not GTE, significantly augmented the proportion of VGluT1 afferent synapses on aged MNs. Moreover, GTE, but not cocoa, reduced aging-associated microgliosis and increased the proportion of neuroprotective microglial phenotypes. Our data indicate that certain plant flavonoids may be beneficial in the nutritional management of age-related deterioration of the neuromuscular system.

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DOI -  https://doi.org/10.18632/aging.203336

Full text - https://www.aging-us.com/article/203336/text

Correspondence to: Jordi Calderó email: jordi.caldero@udl.cat

Keywords: sarcopenia, green tea, neuromuscular system, aging, cocoa

About Aging

Launched in 2009, Aging publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways.

Please visit our website at http://www.Aging-US.com​​ or connect with us on:

Twitter - https://twitter.com/AgingJrnl​
Facebook - https://www.facebook.com/AgingUS/​
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Aging is published by Impact Journals, LLC please visit http://www.ImpactJournals.com​​ or connect with @ImpactJrnls

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Research on Aging-Related Effects of Green Tea and Cocoa

Technology Networks

Psychedelics are being explored for a myriad of neurological and psychiatric conditions. In this video, Technology Networks speak with Professor David Nutt and Anthony Tennyson from Awakn Life Sciences, a Toronto-based company who focus on the use of psychedelics to treat addiction. 

We discussed the unique considerations of treating addiction, the role of psychotherapy in psychedelic treatments and how regulation of psychedelics could change in the near future.

Treating Addiction With Psychedelics: An Interview With Professor David Nutt and Anthony Tennyson, Awakn Life Sciences

Teach Me in 10

For this installment of Teach Me in 10, we are joined by Paul Baniqued. Paul took his undergraduate studies at Mapua University in the Philippines and graduated with a Joint BSc degree in Biological Engineering and Chemistry. He earned his MSc in Manufacturing Engineering at De La Salle University-Manila after working in the Biomedical Devices Innovation and E-Health Research Group and spearheading the Agapay Project: A Robotic Exoskeleton for the Upper Limb Rehabilitation of Filipino Post-Stroke Patients.

In this Teach Me in 10 video, Paul explains more about how virtual reality and robotic exoskeletons can improve brain-computer interfaces.

Brain–Computer Interfaces With Paul Baniqued

Aging published this theory article on November 17, 2018, entitled, “Disease or not, aging is easily treatable,” by Dr. Mikhail V. Blagosklonny from the Department of Cell Stress Biology, Roswell Park Comprehensive Cancer Center, Buffalo, NY.


Abstract:
Is aging a disease? It does not matter because aging is already treated using a combination of several clinically-available drugs, including rapamycin. Whether aging is a disease depends on arbitrary definitions of both disease and aging. For treatment purposes, aging is a deadly disease (or more generally, pre-disease), despite being a normal continuation of normal organismal growth. It must and, importantly, can be successfully treated, thereby delaying classic age-related diseases such as cancer, cardiovascular and metabolic diseases, and neurodegeneration.

To date, this study has generated an Altmetric Attention Score of 54. The Altmetric Attention Score provides an at-a-glance indication of the volume and type of online attention the research has received. 

Top Aging publications rated by Altmetric Attention Score -  https://www.aging-us.com/news_room/altmetric

Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.101647

DOI - https://doi.org/10.18632/aging.101647

Full text - https://www.aging-us.com/article/101647/text

Correspondence to: Mikhail V. Blagosklonny email: mikhail.blagosklonny@roswellpark.org

Keywords: gerossuppresants, senolytics, longevity, lifespan, aging

About Aging

Launched in 2009, Aging publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways.

Please visit our website at http://www.Aging-US.com​​ or connect with us on:

Twitter - https://twitter.com/AgingJrnl​
Facebook - https://www.facebook.com/AgingUS/​
SoundCloud - https://soundcloud.com/aging-us​
YouTube - https://www.youtube.com/agingus​
LinkedIn -  https://www.linkedin.com/company/aging​

Aging is published by Impact Journals, LLC please visit http://www.ImpactJournals.com​​ or connect with @ImpactJrnls

Media Contact
18009220957
MEDIA@IMPACTJOURNALS.COM

Top-Performer: Disease or Not, Aging is Easily Treatable

For this installment of Teach Me in 10, we are joined by Gareth Walkom, the founder of withVR.  Gareth develops virtual reality tools for speech disorders, speech and language pathologists and researchers. Since 2015 he has been researching how virtual reality can be used within stuttering, exploring how virtual reality speaking situations can be used as a powerful tool. 

In this Teach Me in 10 video, Gareth explains more about speech disorders, how virtual reality is helping and the applications of such work.

Virtual Reality and Speech Disorders With Gareth Walkom

Oncotarget

Oncotarget published this research paper on August 11, 2020, entitled, “Survival after resection of brain metastases with white light microscopy versus fluorescence-guidance: A matched cohort analysis of the Metastasys study data,” by researchers from the University of Medicine Goettingen, Goettingen, Germany; University Medical Center Leipzig, Leipzig, Germany; University Hospital Muenster, Muenster, Germany.

The cover for issue 32 of Oncotarget features Figure 2, "This figure depicts overall survival and local in-brain recurrence-free survival in the study's subgroups," by Hussein, et al. which reported that the aim of the present study is to assess whether the use of 5-ALA has an impact on local recurrence or survival compared to conventional white light microscopic tumor resection.

Two groups were compared:
In the “white light” group, resection was performed with conventional microscopy.
In the 5-ALA group, fluorescence guided peritumoral resection was additionally performed after standard microscopic resection.
Local in-brain recurrence occurred in 21/175 patients with a rate of 15/119 in the white light and 6/56 in the 5-ALA group.

The use of 5-ALA did not result in lower in-brain recurrence or mortality compared to the use of white light microscopy.

Dr. Bawarjan Schatlo from the Department of Neurosurgery at The University of Medicine Goettingen said, "Metastatic brain disease is more common than primary brain tumors."

Another group made the case for extending tumor resection 5 millimeters into peritumoral tissue to perform a so-called supramarginal resection.

Its aim is to prolong progression-free survival through radical resection and improved local tumor control.

In a series of 52 patients, Kamp and colleagues detected positive fluorescence in 62% of resected cerebral metastases.

Thus, the utility and importance of using methods to improve local control of brain metastases remains an unresolved issue.

The aim of the current study was to compare survival and local recurrence in a cohort of patients who underwent surgery for brain metastases with 5-ALA fluorescence microscopy to one that was operated using microscopic white light only.

The Schatlo Research Team concluded in their Oncotarget research paper, "the present study confirmed that regardless of surgical adjunct, radiotherapy is strongly associated with improved survival."

To date, this research paper has generated an Altmetric Attention Score of 48. The Altmetric Attention Score provides an at-a-glance indication of the volume and type of online attention the research has received. 

Top Oncotarget publications rated by Altmetric Attention Score - https://www.oncotarget.com/news/altmetric/

Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.27688

DOI - https://doi.org/10.18632/oncotarget.27688

Full text - https://www.oncotarget.com/article/27688/text/

Correspondence to - Bawarjan Schatlo - bawarjan.schatlo@med.uni-goettingen.de

Keywords - brain tumor, brain metastasis, fluorescence-guided surgery, 5-ALA

About Oncotarget

Oncotarget is a bi-weekly, peer-reviewed, open access biomedical journal covering research on all aspects of oncology.

To learn more about Oncotarget, please visit https://www.oncotarget.com or connect with:

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Oncotarget is published by Impact Journals, LLC please visit https://www.ImpactJournals.com or connect with @ImpactJrnls

Media Contact
MEDIA@IMPACTJOURNALS.COM
18009220957

Top-Performer: White Light Versus 5-ALA Fluorescence Guided Resection

Wyss Institute for Biologically Inspired Engineering at Harvard University

This animation explains how Wyss Institute researchers and their industry partners aim to identify novel transport targets and shuttle compounds to enable more effective delivery of drugs to the brain. Credit: Wyss Institute at Harvard University. Learn more at: https://wyss.harvard.edu/collaboration/brain-targeting-program/

Wyss Institute Brain Targeting Program

This installment of Teach Me in 10 features Tom Veale, a PhD student at the Dementia Research Centre at the University College of London. In this episode of Teach Me in 10, Veale talks broadly about dementia and Alzheimer's disease, the brain changes that occur and white matter's involvement in Alzheimer's disease.

White Matter in Alzheimer's Disease and Dementia With Tom Veale

This week at Teach Me in 10, we are joined by Oded Rechavi, a professor in molecular biology at Tel Aviv University in Israel. The tagline for the Rechavi lab is "The Laboratory for Radical Science", and in this ten-minute talk, you will learn why. Rechavi's research spans various different topics, including the study of novel mechanisms of inheritance and applying genomics analyses to the ancient Dead Sea Scrolls. To learn more about the Rechavi laboratory, you can visit the website, or read the profile piece Technology Networks published in 2020.

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