Microfluidics

Teach Me in 10

The human brain is incredibly complex, and this makes it hard to study. Hence, a lack of accurate tissue models presents a significant bottleneck to important biological and psychological research. To accurately model the human brain, researchers have developed smaller tissue models that mimic specific brain regions – such as the blood-brain barrier (BBB).

The BBB is an important feature of the human brain as it selectively mediates communication between the lymphatic system and the central nervous system (CNS). The BBB prevents large molecules and disease-causing microorganisms from entering the brain tissue and keeps the CNS safe. Using organ-on-a-chip technology, researchers at the IITB Monash Research Academy in Mumbai (India) have developed a new tissue model capable of biomimicking the human BBB. The new ‘brain-on-a chip’ utilizes Cayley-tree geometry and heterogeneous fluid shear stress forces to ensure the integrity of a 3D endothelial lumen.

In this Teach Me in 10, researcher Ami Mehta will explain how her new BBB model can be used to study neuroinflammatory conditions with the potential to improve the study of drug transport into the brain.

Biomimicking the Brain Vasculature With a Microfluidic Chip With Ami Mehta

Wyss Institute for Biologically Inspired Engineering at Harvard University

This animation explains how Wyss Institute researchers and their industry partners aim to identify novel transport targets and shuttle compounds to enable more effective delivery of drugs to the brain. Credit: Wyss Institute at Harvard University. Learn more at: https://wyss.harvard.edu/collaboration/brain-targeting-program/

Wyss Institute Brain Targeting Program

CN Bio

CN Bio’s mission is to transform drug discovery through the development of disruptive single and multi-organ microphysiological systems (MPS), otherwise known as organ-on-a-chip, that optimise the accuracy and productivity of bringing new medicines to market. By supporting more efficient drug discovery, before having to go to advanced and expensive animal or human clinical trials, CN Bio’s MPS can provide significant savings in cost and time.

This short video will introduce you to CN Bio and what differentiates us as a company. It details:

1) our mission to help improve the accuracy and efficiency of drug discovery by providing researchers with the ability to generate predictive human-relevant information. 

2) use of advanced single and multi-organ in vitro models, cultured using CN Bio's PhysioMimix™ OOC, to facilitate faster, cheaper and more insightful decisions regarding compound progression into the clinic versus traditional techniques alone.

3) the benefits of an organ-on-a-chip approach to drug metabolism and toxicology applications such as DILI, Human ADME, metabolite driven toxicity, on and off-target effects 

4) how to access this technology in your own lab, or through our in house testing services

Predicting the future: humanized drug evaluation testing using organ-on-a-chip technology

Discover the benefits of CN Bio's in vitro organ-on-a-chip (OOC) approach to drug metabolism and toxicology applications.

In just 60 seconds, we will explain how the PhysioMimix™ OOC from CN Bio, provides researchers within the pharmaceutical industry with human-relevant and predictive information through the use of advanced single and multi-organ in vitro models and assays.

The benefits of human-relevant in vitro drug metabolism and toxicology applications from CN Bio in 60 seconds

HTA srl

HT1500U can be used in a number of flow-through-cell (also known as flow-through cuvette or quartz cell) applications such as: UV-VIS, NIR, colorimeters and many more. HT1500U is the best choice for anyone who is looking for immediate automation, potentially avoiding the need to source an expensive sipper.
Beside the undoubted productivity boost, HT1500U will increase analysis robustness and will significatively reduce carry-over: you can indeed programme as many washing cycles as you need for this purpose; sample replicas and calibration curve could be conveniently run whenever needed with no fuss. Moreover, in case you have a precious sample to analyse, you should not worry anymore about product handling (with the relative risk of sample spill or waste): HT1500U could automatically bring back the sample inside its vessel after the analysis instead of displacing it to the waste tank.

HT1500U can be deployed in any environment, lab or production, and operated by anyone with no or minimal training. Just load the samples on the autosampler carousel and press the start button: the autosampler and the spectrophotometer or colorimeter will take care of your analysis for you.

HT1500: Autosampler for Flow-Through cell applications (UV-VIS, NIR spectrophotometer and colorimeter)

NanoTemper

Visit NanoTemper headquarters with Matthias Molnar, the Monolith Product Manager and meet the team who put their brains together to create the new Monolith. The new instrument combines the accuracy and sensitivity of original Monolith NT.115 instruments with the benefits of simpler and faster assay development, shorter run times, increased flexibility, and higher throughput. It's been completely re-designed for better usability and for greater precision and reproducibility of measurement data.

Characterize your most challenging interactions with Monolith

Current manufacturing methods release harmful greenhouse gases and pollution, and many of the products produced do not biodegrade, damaging our ecosystems even further. What if we could turn greenhouse gases into biodegradable products? Researchers at the Wyss Institute are using synthetic biology to make this a reality. For more information, please visit: https://wyss.harvard.edu/technology/circe-transforming-greenhouse-gases-into-biodegradable-products/ Credit: Wyss Institute at Harvard University

Circe: Using Microbes to Make Biodegradable Products

In this instalment of Teach Me in 10, we're joined by Benita Olivier, a professor and researcher in the field of musculoskeletal physiotherapy in the Department of Physiotherapy, University of the Witwatersrand, South Africa.

Olivier has a huge passion for research, but also a passion for improving the lives of researchers. To that end, she created a website – Research Masterminds – through which she shares solutions for making various aspects of postgraduate and academic life easier. In this Teach Me in 10, Olivier discusses some valuable tips and tricks for writing your first scientific paper. 

You can find out more about Olivier's work at:
https://researchmasterminds.com/


Teach Me in 10 – Tips for Writing Your First Scientific Paper With Professor Benita Olivier

Smart Thermally Actuating Textiles (STATs) are tightly-sealed pouches that are able to change shape or maintain their pressure even in environments in which the exterior temperature or airflow fluctuates. This soft robotics technology could be developed as novel components of rehabilitation therapies or to prevent tissue damage in hospital bed or wheelchair-bound individuals. For more information, please visit: [https://wyss.harvard.edu/news/robotic-textiles-are-fueled-up-and-take-action Credit: Wyss Institute at Harvard University

Microfluidics

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