Environmental Monitoring

BÜCHI Labortechnik AG

Are you looking for a powerful tool to assist in high-throughput sample drying or concentration? Look no further than the BUCHI SyncorePlus parallel evaporator.  

Join us for this 4-minute demo that showcases its easy-to-use automation features that make sample processing an easy task. Whether you're working on new drug synthesis or post-extraction solvent removal, the SyncorePlus provides controlled and gentle evaporation to ensure the best results possible. 

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SyncorePlus Parallel Evaporator - Mini Demo

Lonza

Learn how Lonza’s MODA® Platform can help you by facilitating paperless execution across manufacturing & QC processes.

The MODA® Platform: Digitalizing Quality & Manufacturing

Teach Me in 10

During this presentation, we will discuss environmental monitoring, including regulatory expectations, and briefly present our Applied Biosystems MicroSEQ™ Rapid microbial identification system.  Used in top pharmaceutical companies worldwide, the microbial identification system is an end-to-end rapid genotypic sequencing solution, based on ribosomal gene sequencing for bacterial and fungal species-level identification, generating accurate results in less than 5 hours.

The Science Behind Pristine Production: Environmental Monitoring in Biopharmaceutical Facilities

Aging (Aging-US)

Aging-US published this research paper on August 29, 2023 in Volume 15, Issue 16, entitled, “Reorganization of pancreas circadian transcriptome with aging" by researchers from the Rush Center for Integrated Microbiome and Chronobiology Research, Rush University Medical Center, Chicago, IL; Division of Allergy and Immunology, Department of Internal Medicine, Rush University Medical Center, Chicago, IL; University of Wisconsin-Parkside, Department: Biological Sciences, Kenosha, WI; Department of Internal Medicine, Division of Gastroenterology, Rush University Medical Center, Chicago, IL; Department of Anatomy and Cell Biology, Rush University Medical Center, Chicago, IL.

DOI - https://doi.org/10.18632/aging.204929

Corresponding author - Faraz Bishehsari - Faraz_Bishehsari@rush.edu

Abstract

The evolutionarily conserved circadian system allows organisms to synchronize internal processes with 24-h cycling environmental timing cues, ensuring optimal adaptation. Like other organs, the pancreas function is under circadian control. Recent evidence suggests that aging by itself is associated with altered circadian homeostasis in different tissues which could affect the organ’s resiliency to aging-related pathologies. Pancreas pathologies of either endocrine or exocrine components are age-related. Whether pancreas circadian transcriptome output is affected by age is still unknown. To address this, here we profiled the impact of age on the pancreatic transcriptome over a full circadian cycle and elucidated a circadian transcriptome reorganization of pancreas by aging. Our study highlights gain of rhythms in the extrinsic cellular pathways in the aged pancreas and extends a potential role to fibroblast-associated mechanisms.

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Keywords - aging, circadian rhythms, RNA transcriptomics, pancreas

About Aging-US

Launched in 2009, Aging-US publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging-US go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways.

Please visit our website at https://www.Aging-US.com​​ and connect with us:

SoundCloud - https://soundcloud.com/Aging-Us
Facebook - https://www.facebook.com/AgingUS/
Twitter - https://twitter.com/AgingJrnl
Instagram - https://www.instagram.com/agingjrnl/
YouTube - https://www.youtube.com/@AgingJournal
LinkedIn - https://www.linkedin.com/company/aging/
Pinterest - https://www.pinterest.com/AgingUS/

Media Contact
18009220957
MEDIA@IMPACTJOURNALS.COM

Reorganization of Pancreas Circadian Transcriptome with Aging | Aging-US

Agilent Technologies

Take a musical journey through the challenges of sample preparation for small molecules, food testing, drug screening, and more. Each verse will show you how to go from sample preparation stress to success.

Stressed About Sample Prep? Agilent can help!

Aging-US published this trending research paper on August 14, 2023, in Volume 15, Issue 15, entitled, “Associations between klotho and telomere biology in high stress caregivers" by researchers from the Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, CA; Department of Biochemistry and Biophysics, University of California, San Francisco, CA; Department of Neurology and Weill Institute of Neurosciences, University of California, San Francisco, CA.

DOI - https://doi.org/10.18632/aging.204961

Corresponding author - Ryan L. Brown - ryan.brown@ucsf.edu

Abstract

Aging biomarkers may be related to each other through direct co-regulation and/or through being regulated by common processes associated with chronological aging or stress. Klotho is an aging regulator that acts as a circulating hormone with critical involvement in regulating insulin signaling, phosphate homeostasis, oxidative stress, and age-related inflammatory functioning. Both klotho and telomere length are biomarkers of biological aging and decrease with age; however, the relationship between them is not well understood. Here we test the association between klotho levels and the telomere length of specific sorted immune cells among a healthy sample of mothers caregiving for a child with autism spectrum disorder (ASD; i.e., experiencing higher caregiving stress) or a child without ASD, covarying age and body mass index, in order to understand if high stress associated with caregiving for a child with an ASD may be involved in any association between these aging biomarkers. In 178 caregiving women (n = 90 high-stress mothers of children with ASD, n = 88 low-stress mothers of neurotypical children), we found that klotho levels were positively associated with telomere length in PBMCs (an effect driven by CD4+ and CD8+CD28− T cells) among high-stress mothers of children with an ASD but not among low-stress mothers of neurotypical children. There were no significant associations between klotho and telomerase activity in either group, across cell types assessed here. Our results suggest that klotho levels and telomere length may be associated through a coordinated downregulation of longevity factors occurring under higher stress caregiving conditions.

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Keywords - aging, aging biology, stress, klotho, telomeres, telomerase

About Aging-US

Launched in 2009, Aging-US publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging-US go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways.

Please visit our website at https://www.Aging-US.com​​ and connect with us:

SoundCloud - https://soundcloud.com/Aging-Us
Facebook - https://www.facebook.com/AgingUS/
Twitter - https://twitter.com/AgingJrnl
Instagram - https://www.instagram.com/agingjrnl/
YouTube - https://www.youtube.com/@AgingJournal
LinkedIn - https://www.linkedin.com/company/aging/
Pinterest - https://www.pinterest.com/AgingUS/

Media Contact
18009220957
MEDIA@IMPACTJOURNALS.COM

Associations Between Klotho and Telomere Biology in High Stress Caregivers | Aging-US

In this video, we take a show TKN analysis, a critical method for determining total Kjeldahl nitrogen (TKN) in soil and wastewater samples. 

TKN is a key indicator of the nitrogen content in environmental samples, providing critical information for monitoring and assessing environmental impacts. We demonstrate each step of the Kjeldahl method for TKN determination, which involves digestion, distillation and titration, and how it can be applied to both soil and wastewater samples. 

During the video, we will also highlight the importance of accessories that you can use that are specific for environmental samples, emphasizing the need for analytical safety to protect both the operator and the sample.

We will also show how to efficiently determine nitrogen by using an autosampler and automatic dosing, aspiration and titration which is improving the efficiency and accuracy of the overall analysis process. 

Join us as we delve into the world of TKN analysis, exploring the steps to determine Kjeldahl nitrogen in soil and wastewater samples. With the Kjeldahl method and the latest features in distillation units, we can achieve reliable and accurate results, contributing to a safer and healthier environment for all purposes.

TKN Analysis of Environmental Samples: Soil and Wastewater Kjeldahl Nitrogen Determination

Rawcubes

Experience the seamless integration of workflows, predictive maintenance, ensure smooth machine operations with iDataOps, our advanced machine monitoring software.

Stay ahead of the competition with Rawcubes.

Learn more about iDataOps here - https://lnkd.in/dg2h5gjP

#smartmanufacturing#machinemonitoring#machinemaintenance

Machine Monitoring Software

Aging-US published this research paper on July 10, 2023 in Volume 15, Issue 13, entitled, “MSK1 is required for the beneficial synaptic and cognitive effects of enriched experience across the lifespan" by researchers from the School of Life Sciences, University of Warwick, Coventry CV4 7AL, UK; School of Pharmacy and Biomedical Sciences, University of Central Lancashire, Preston PR1 2HE, UK; School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.

DOI - https://doi.org/10.18632/aging.204833

Corresponding author - Bruno G. Frenguelli - b.g.frenguelli@warwick.ac.uk

Abstract

Positive experiences, such as social interaction, cognitive training and physical exercise, have been shown to ameliorate some of the harms to cognition associated with ageing. Animal models of positive interventions, commonly known as environmental enrichment, strongly influence neuronal morphology and synaptic function and enhance cognitive performance. While the profound structural and functional benefits of enrichment have been appreciated for decades, little is known as to how the environment influences neurons to respond and adapt to these positive sensory experiences. We show that adult and aged male wild-type mice that underwent a 10-week environmental enrichment protocol demonstrated improved performance in a variety of behavioural tasks, including those testing spatial working and spatial reference memory, and an enhancement in hippocampal LTP. Aged animals in particular benefitted from enrichment, performing spatial memory tasks at levels similar to healthy adult mice. Many of these benefits, including in gene expression, were absent in mice with a mutation in an enzyme, MSK1, which is activated by BDNF, a growth factor implicated in rodent and human cognition. We conclude that enrichment is beneficial across the lifespan and that MSK1 is required for the full extent of these experience-induced improvements of cognitive abilities, synaptic plasticity and gene expression.

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Keywords - aging, cognitive reserve, synaptic plasticity, anxiety, spatial memory, LTP

About Aging-US

Launched in 2009, Aging-US publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging-US go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways.

Please visit our website at https://www.Aging-US.com​​ and connect with us:

SoundCloud - https://soundcloud.com/Aging-Us
Facebook - https://www.facebook.com/AgingUS/
Twitter - https://twitter.com/AgingJrnl
Instagram - https://www.instagram.com/agingjrnl/
YouTube - https://www.youtube.com/@AgingJournal
LinkedIn - https://www.linkedin.com/company/aging/
Pinterest - https://www.pinterest.com/AgingUS/

Media Contact
18009220957
MEDIA@IMPACTJOURNALS.COM

Environmental Monitoring

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