Diagnostics

Oncotarget

Oncotarget published this trending research paper chosen as the cover for Volume 12, Issue 6, entitled, "Genomic and neoantigen evolution from primary tumor to first metastases in head and neck squamous cell carcinoma," by researchers from the Division of Medical Oncology, Washington University in St. Louis, St. Louis, MO; McDonnell Genome Institute, Washington University in St. Louis, St. Louis, MO; Department of Pathology and Cell Biology, Columbia University, New York, NY; Division of Hematology/Oncology, Columbia University, New York, NY; Department of Genetics, Washington University in St. Louis, St. Louis, MO; Division of Pediatric Hematology and Oncology, St. Louis Children’s Hospital, St. Louis, MO; Siteman Cancer Center, St. Louis, MO.

Abstract:
Head and neck cell squamous-cell carcinomas (HNSCC) are a group of common cancers typically associated with tobacco use and human papilloma virus infection. Up to half of all cases will suffer a recurrence after primary treatment. As such, new therapies are needed, including therapies which promote the anti-tumor immune response. Prior work has characterized changes in the mutation burden between primary and recurrent tumors; however, little work has characterized the changes in neoantigen evolution. We characterized genomic and neoantigen changes between 23 paired primary and recurrent HNSCC tumors. Twenty-three biopsies from patients originally diagnosed with locally advanced disease were identified from the Washington University tumor bank. Whole exosome sequencing, RNA-seq, and immunohistochemistry was performed on the primary and recurrent tumors. Within these tumors, we identified 6 genes which have predicted neoantigens in 4 or more patients. Interestingly, patients with neoantigens in these shared genes had increased CD3+ CD8+ T cell infiltration and duration of survival with disease. Within HNSCC tumors examined here, there are neoantigens in shared genes by a subset of patients. The presence of neoantigens in these shared genes may promote an anti-tumor immune response which controls tumor progression.

Press release - https://www.oncotarget.com/news/pr/genomic-and-neoantigen-evolution-in-head-and-neck-squamous-cell-carcinoma/

Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.27907

DOI - https://doi.org/10.18632/oncotarget.27907

Full text - https://www.oncotarget.com/article/27907/text/

Correspondence to - Brian A. Van Tine - bvantine@wustl.edu

Keywords - head and neck squamous cell carcinoma, neoantigens, mutational evolution, tumor relapse, immune cell infiltration

About Oncotarget:

Oncotarget is a bi-weekly, peer-reviewed, open access biomedical journal covering research on all aspects of oncology.

To learn more about Oncotarget, please visit www.oncotarget.com or follow us:

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Oncotarget is published by Impact Journals, LLC please visit www.ImpactJournals.com or connect with @ImpactJrnls

Media Contact
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18009220957x105

Paper Spotlight: Genomic and Neoantigen Evolution in Head, Neck Cancer

Creative Enzymes

Learn more about Industrial Enzyme Production at Creative Enzymes at  https://www.creative-enzymes.com/service/industrial-enzyme-production_380.html

Industrial Enzyme Production

Creative Enzymes is a professional and experienced supplier of probiotics. In the past decade, Creative Enzymes mainly provides enzyme-related products and services. With the continuous expansion of business areas and scale, we have set foot in other areas and established a sound probiotic production and supply chain. Based on our high-quality products and services, as well as the unique advantages of large-scale production, our probiotic products are widely favored by industrial customers and scientific research customers.  More information at https://probiotic.creative-enzymes.com/

Introduction to Probiotics

Technology Networks

Speaking at the ‘Advances in Proteomics & Metabolomics’ online symposium 2021, Professor Stephen Pennington from University College Dublin and Atturos Ltd; presented his talk on ‘Using Proteomics to Develop Advanced Protein Biomarker Tests that Address Key Unmet Clinical Needs in Psoriatic Disease.’
Abstract: 
In this presentation the challenges of developing new protein biomarker tests and delivering them to use for patient benefit will be described and possible solutions introduced. Emphasis will be placed on the analytical validation of new multiplexed protein biomarker assays and their use in multi-centre evaluation and validation studies to support the development of new tests to improve patient outcomes in psoriatic disease.  Patient engagement and use of patient-centric sampling devices for effective test delivery will be described.

Using Proteomics to Develop Advanced Protein Biomarker Tests that Address Key Unmet Clinical Needs in Psoriatic Disease.

Aging (Aging-US)

Aging-US published this trending research paper selected as the cover for Volume 13, Issue 23, entitled, “An efficient, non-invasive approach for in-vivo sampling of hair follicles: design and applications in monitoring DNA damage and aging” by researchers from the Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University and University Hospital Olomouc, Olomouc, Czech Republic; Faculty of Science, Palacky University and University Hospital in Olomouc, Olomouc, Czech Republic; Danish Cancer Society Research Center, Copenhagen, Denmark; Division of Genome Biology, Department of Medical Biochemistry and Biophysics, Science for Life Laboratory, Karolinska Institute, Stockholm, Sweden.

Abstract
In accordance with the 3 Rs principle (to replace, reduce and refine) animal models in biomedical research, we have developed and applied a new approach for sampling and analyzing hair follicles in various experimental settings. This involves use of a convenient device for non-invasive collection of hair follicles and processing methods that provide sufficient amounts of biological material to replace stressful and painful biopsies. Moreover, the main components of hair follicles are live cells of epithelial origin, which are highly relevant for most types of malignant tumors, so they provide opportunities for studying aging-related pathologies including cancer. Here, we report the successful use of the method to obtain mouse hair follicular cells for genotyping, quantitative PCR, and quantitative immunofluorescence. We present proof of concept data demonstrating its utility for routine genotyping and monitoring changes in quality and expression levels of selected proteins in mice after gamma irradiation and during natural or experimentally induced aging. We also performed pilot translation of animal experiments to human hair follicles irradiated ex vivo. Our results highlight the value of hair follicles as biological material for convenient in vivo sampling and processing in both translational research and routine applications, with a broad range of ethical and logistic advantages over currently used biopsy-based approaches.

Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.203744

DOI - https://doi.org/10.18632/aging.203744

Full Text - https://www.aging-us.com/article/203744/text

Correspondence to: Martin Mistrik email: martin.mistrik@upol.cz and Marian Hajduch email: marian.hajduch@upol.cz

Keywords: hair follicle cells, non-invasive sampling, irradiation, cellular senescence, DNA damage response

About Aging-US

Launched in 2009, Aging-US publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging-US go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways.

Please visit our website at http://www.Aging-US.com​​ or connect with us on:

SoundCloud - https://soundcloud.com/Aging-Us
Facebook - https://www.facebook.com/AgingUS/
Twitter - https://twitter.com/AgingJrnl
Instagram - https://www.instagram.com/agingjrnl/
YouTube - https://www.youtube.com/agingus​
LinkedIn - https://www.linkedin.com/company/aging/
Pinterest - https://www.pinterest.com/AgingUS/

Aging-US is published by Impact Journals, LLC please visit http://www.ImpactJournals.com​​ or connect with @ImpactJrnls

Media Contact
18009220957
MEDIA@IMPACTJOURNALS.COM

Novel Follicular Cells’ Collector for Aging and Cancer Research

Medicon Hellas SA

Behind the scenes look at Medicon Hellas SA.
Founded in 1978, Medicon has a wide range of activities in the IVD sector, the main being the Development and Production of In Vitro Diagnostic Reagents.

www.mediconsa.com/en/

Medicon, Company Presentation

Bruker Mass Spectrometry

Glycosylation is seen as playing a key role in tumor development.   Researchers at the Bruker-MUSC Clinical Glycomics Center of Excellence are developing and applying new technologies to map glycans in tissue and classify changes that occur during development of cancer.  Glycans present on each glycoprotein in the tissue are analyzed using MALDI Imaging mass spectrometry, a label-free molecular imaging technique, to correlate specific glycan distributions with disease.  Currently used only for research purposes, if brought to market, these tools promise earlier cancer detection and customized therapies.  Learn more by watching this presentation by Dr. Richard Drake.

Agents of Change: Tracking Tumor Progression With MALDI Imaging of Glycans

In this episode, we explore using infection models to understand immunity. Learn more with Agilent here: https://technet.works/InfectionandImmunity

Using infection models to understand immunity

BioFluidix

The BioSpot CP is designed to realize complex laboratory tasks. Beside the standard BioSpot features like automated droplet volume calibration, aspiration and nozzle wash, nanoliter droplet dispensing, substrate ionizing and many more, the CP features an individual Z positioning per dispense channel. This allows for a multi-dimension addressability of any substrate. 
It's specific application is the parallelization of diagnostic tests in standard well plates and for combinatory chemistry (DoE). 
Get in touch to learn more about the BioSpot® workstation CP 600 at info@biofluidix.com.

Diagnostics

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