Diagnostics

Luminex Corporation

Get to market faster with LuminexPLORE Lab custom assay development and multiplex testing services. Our team of scientists combine technical precision with industry-leading xMAP® and xTAG® technologies to produce highly specific proteomic and genomic multiplex assays.

We welcome you to come and uncover LuminexPLORE Lab services to meet your specific needs from drug discovery applications, biomarker analysis, testing services and more.

Learn more: luminexcorp.com/luminexplore

Get to Market Faster – LuminexPLORE Lab xMAP® Custom Assay Development Services

Creative Enzymes

Learn more about Industrial Enzyme Production at Creative Enzymes at  https://www.creative-enzymes.com/service/industrial-enzyme-production_380.html

Industrial Enzyme Production

Teach Me in 10

In today’s pharmaceutical QC laboratories, QC analysts face a myriad of challenges. QC analysts are required to execute and document a series of complex tasks in compliance with a stringent set of standards and regulations, while addressing the added pressures of increasing throughput often with reduced levels of staffing and training. Other stressors on the analyst include generation of out-of-specification results, access to instrumentation, instrument downtime, and inefficient workflows. These challenges may result in risks to data integrity, decreased productivity, and increased analyst burnout and turnover.

Today’s technology provides the means to reduce errors, improve productivity and efficiency, and ensure data integrity, thus decreasing the burden on the QC analyst. An example of this technology is the Waters Alliance iS HPLC system. The system was specifically created for the QC laboratory and will assist QC analysts performing HPLC analyses by:
• Reducing up to 40% of common errors*
• Providing fast, simple guidance the point of need
• Increasing productivity and efficiency through resource utilization and error free operation
• Driving workflow efficiencies
• Improving data integrity.

*Based on Waters’ market research in 2022, surveying 56 global pharma QC labs running >25 systems.

Reducing the Challenges Facing Pharmaceutical QC Analysts

In this Teach me in 10 episode we will explore how simultaneous sequencing of genetic and epigenetic bases in cfDNA allows for early cancer detection.

The development of high-throughput DNA sequencing has been key in illuminating cellular processes and understanding how variation and mutations play a role in disease states, such as cancer.
But it’s not just genetic sequences that control cellular fate and function – epigenetic modifications regulate gene expression in response to changes in behaviour or environment and play a key role in many biological processes. Variation in an individual’s genetic sequence will be associated with variation in DNA methylation that can functionally determine predisposition for disease.

Advances in measuring both genetic and epigenetic variation in the context of the other is therefore important for revealing dynamic biological processes, allowing a more comprehensive view of cellular function.

Unlocking the Potential of Genetics and Epigenetics for Early Cancer Detection

Thermo Fisher Scientific | qPCR

The Power of One: One connection. One interface. One workflow. Diomni Enterprise Software.

Learn more at thermofisher.com/diomni

For In Vitro Diagnostic Use.

Get Ready To Experience the Power of One

In this video, Dr. Charles Rosser, a board-certified urologist with extensive clinical research and biotechnology industry experience, discusses the development and commercialization of Oncuria, a new laboratory developed test for early detection of bladder cancer using Luminex technology. 

He explains the benefits of Luminex platform and the challenges of commercializing a diagnostic tool. He also shares his positive experience working with R&D Systems reagents and discusses the importance of proteomic tools in early cancer detection. This interview provides valuable insights for researchers and biotech professionals interested in developing diagnostic tools.

Early Detection of Bladder Cancer with Oncuria

Custom Videos from Technology Networks

In this informative video, you will discover the latest technologies and workflows used in the field of cell and gene therapy.

Cell and Gene Therapy Workflows with Bio-Rad

Life Solved

In this episode of Life Solved, Dr Fay Couceiro shares the latest on an exciting partnership between the University of Portsmouth and a 2,000 mile competitive rowing event.

In the Summer of 2022, GB Row participants set out to row the length of the UK coastline, but not only that, they were gathering data to help study and map the health of our oceans.

The teams took samples with specially designed equipment to capture insights from sound waves to microplastics and environmental DNA.

Fay explains how this data is allowing us unrivalled insights into the extent of plastics pollution and biodiversity loss in these waters. 

To listen to the full episode search 'Life Solved' wherever you listen to podcasts, or click here: https://podfollow.com/uoplifesolved/view 

You can find out more about this work and other research at the University of Portsmouth website: https://www.port.ac.uk/research/research-projects

Mapping Microplastics in UK Waters With GB Row | Life Solved

Aging (Aging-US)

Aging-US published this research paper as the cover for Volume 15, Issue 3, entitled, "Immune-mediated platelet depletion augments Alzheimer’s disease neuropathological hallmarks in APP-PS1 mice" by researchers from Institute of Molecular Regenerative Medicine, Paracelsus Medical University, Salzburg, Austria, Spinal Cord Injury and Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria, Institute of Experimental Neuroregeneration, Paracelsus Medical University, Salzburg, Austria, Department of Transfusion Medicine, University Clinic, Paracelsus Medical University, Salzburg, Austria, Austrian Cluster for Tissue Regeneration, Vienna, Austria.

DOI - https://doi.org/10.18632/aging.204502

Corresponding author - Kathrin Maria Kniewallner - kathrin.drerup@pmu.ac.at 

Abstract

In Alzheimer’s disease (AD), platelets become dysfunctional and might contribute to amyloid beta deposition. Here, we depleted platelets in one-year-old APP Swedish PS1 dE9 (APP-PS1) transgenic mice for five days, using intraperitoneal injections of an anti-CD42b antibody, and assessed changes in cerebral amyloidosis, plaque-associated neuritic dystrophy and gliosis. In APP-PS1 female mice, platelet depletion shifted amyloid plaque size distribution towards bigger plaques and increased neuritic dystrophy in the hippocampus. In platelet-depleted females, plaque-associated Iba1+ microglia had lower amounts of fibrillar amyloid beta cargo and GFAP+ astrocytic processes showed a higher overlap with thioflavin S+ amyloid plaques. In contrast to the popular hypothesis that platelets foster plaque pathology, our data suggest that platelets might limit plaque growth and attenuate plaque-related neuritic dystrophy at advanced stages of amyloid plaque pathology in APP-PS1 female mice. Whether the changes in amyloid plaque pathology are due to a direct effect on amyloid beta deposition or are a consequence of altered glial function needs to be further elucidated.

Sign up for free Altmetric alerts about this article - 
https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.204502

Keywords - Alzheimer’s disease, platelets, amyloid-beta, microglia, astrocytes

About Aging-US

Launched in 2009, Aging-US publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging-US go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways.

Please visit our website at https://www.Aging-US.com​​ and connect with us:

SoundCloud - https://soundcloud.com/Aging-Us
Facebook - https://www.facebook.com/AgingUS/
Twitter - https://twitter.com/AgingJrnl
Instagram - https://www.instagram.com/agingjrnl/
YouTube - https://www.youtube.com/@AgingJournal
LinkedIn - https://www.linkedin.com/company/aging/
Pinterest - https://www.pinterest.com/AgingUS/

Media Contact
18009220957
MEDIA@IMPACTJOURNALS.COM

Diagnostics

Refine By

Keep up to date with all your favourite videos and channels.

Get personalised notifications on new releases and channel content by subscribing to the LabTube eNewsletter.