Genomics

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In this informative video, you will discover the latest technologies and workflows used in the field of cell and gene therapy.

Cell and Gene Therapy Workflows with BIORAD

Agilent Diagnostics & Genomics Group

The right sequencing data analysis and interpretation solution for your lab. With our suite of sequencing analysis tools, you can design a custom panel, analyze your genomic data, interpret your findings in the context of relevant databases, and manage your laboratory information with ease.  The Alissa Clinical Informatics Platform offers integrated sequencing analysis solutions to manage data, helping you to identify, triage and classify variants and generate customizable reports for clinical NGS and CGH.

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Agilent Alissa Clinical Informatics Platform

CD Genomics

CD genomics can provide microorganism quantification amplicon sequencing based on 16S external standard sequences to obtain absolute abundance data for species in the sample. The 16S amplicon library is constructed and sequenced by adding a synthetic sequence of known copy number to the sample DNA, and then a standard curve is drawn according to the number of amplicon reads and the absolute copy number of the external standard sequence. And finally the absolute copy number of the 16S rRNA gene of the corresponding species of the OTU representative sequence in the sample is calculated. More information at https://www.cd-genomics.com/absolute-quantitative-16s-18s-its-amplicon-sequencing.html

Bioinformatics Analysis of 16s rRNA Amplicon Sequencing Data

CD Genomics has further optimized the process to exceed PacBio’s benchmarks in output and read length to support long-read metagenomic sequencing, and reduce some splicing errors and effectively improve the resolution of microbial community profiling. https://www.cd-genomics.com/Long-Read-Metagenomic-Sequencing.html

What is Metagenomics?

16S rRNA gene sequencing is commonly used for identification, classification and quantitation of microbes within complex biological mixture. In brief, the hypervariable regions of 16s rDNA in prokaryote are amplified by PCR.  The CD genomics can provide microorganism quantification amplicon sequencing based on 16S external standard sequences to obtain absolute abundance data for species in the sample. The 16S amplicon library is constructed and sequenced by adding a synthetic sequence of known copy number to the sample DNA, and then a standard curve is drawn according to the number of amplicon reads and the absolute copy number of the external standard sequence.  https://www.cd-genomics.com/absolute-quantitative-16s-18s-its-amplicon-sequencing.html

What Is 16s rRNA sequencing？

CD Genomics is committed to providing novel NGS services enabling researchers to explore structure and function of the microbial community in a high-resolution and culture-independent manner using technology from Illumina and PacBio. In addition, we also offer the service to sequence the genome of the individual cultured bacteria, fungi, phage or virus, whether do novo or re-sequencing. https://www.cd-genomics.com/Microbial-Genomics.html

Microbial Genomics Solutions at CD Genomics

Aging (Aging-US)

Aging-US published this research paper as the cover for Volume 15, Issue 3, entitled, "Immune-mediated platelet depletion augments Alzheimer’s disease neuropathological hallmarks in APP-PS1 mice" by researchers from Institute of Molecular Regenerative Medicine, Paracelsus Medical University, Salzburg, Austria, Spinal Cord Injury and Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria, Institute of Experimental Neuroregeneration, Paracelsus Medical University, Salzburg, Austria, Department of Transfusion Medicine, University Clinic, Paracelsus Medical University, Salzburg, Austria, Austrian Cluster for Tissue Regeneration, Vienna, Austria.

DOI - https://doi.org/10.18632/aging.204502

Corresponding author - Kathrin Maria Kniewallner - kathrin.drerup@pmu.ac.at 

Abstract

In Alzheimer’s disease (AD), platelets become dysfunctional and might contribute to amyloid beta deposition. Here, we depleted platelets in one-year-old APP Swedish PS1 dE9 (APP-PS1) transgenic mice for five days, using intraperitoneal injections of an anti-CD42b antibody, and assessed changes in cerebral amyloidosis, plaque-associated neuritic dystrophy and gliosis. In APP-PS1 female mice, platelet depletion shifted amyloid plaque size distribution towards bigger plaques and increased neuritic dystrophy in the hippocampus. In platelet-depleted females, plaque-associated Iba1+ microglia had lower amounts of fibrillar amyloid beta cargo and GFAP+ astrocytic processes showed a higher overlap with thioflavin S+ amyloid plaques. In contrast to the popular hypothesis that platelets foster plaque pathology, our data suggest that platelets might limit plaque growth and attenuate plaque-related neuritic dystrophy at advanced stages of amyloid plaque pathology in APP-PS1 female mice. Whether the changes in amyloid plaque pathology are due to a direct effect on amyloid beta deposition or are a consequence of altered glial function needs to be further elucidated.

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Keywords - Alzheimer’s disease, platelets, amyloid-beta, microglia, astrocytes

About Aging-US

Launched in 2009, Aging-US publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging-US go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways.

Please visit our website at https://www.Aging-US.com​​ and connect with us:

SoundCloud - https://soundcloud.com/Aging-Us
Facebook - https://www.facebook.com/AgingUS/
Twitter - https://twitter.com/AgingJrnl
Instagram - https://www.instagram.com/agingjrnl/
YouTube - https://www.youtube.com/@AgingJournal
LinkedIn - https://www.linkedin.com/company/aging/
Pinterest - https://www.pinterest.com/AgingUS/

Media Contact
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MEDIA@IMPACTJOURNALS.COM

Platelet Depletion Augments Alzheimer’s Disease Neuropathological Hallmarks

To support the increasing research interest in small RNA, CD Genomics is offering the qualified small RNA sequencing service that covers novel small RNA discovery, mutation characterization, and expression profiling of small RNAs by leveraging of advanced NGS technologies and data analysis pipeline.	https://www.cd-genomics.com/Small-RNA.html

Small RNA Sequencing: Challengs and Workflow

CD Genomics has been providing the accurate and affordable whole genome sequencing service for couple of years. We combine both Illumina (short reads) and PacBio (long reads) platforms to achieve whole genome de novo assemblies and re-sequencing for viruses, microbes, plants, animals and humans.	https://www.cd-genomics.com/Whole-Genome-Sequencing.html

Genomics

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