Food and Beverage

Aging (Aging-US)

The researchers recruited healthy older participants to two groups according to their history of tea drinking frequency and investigated both functional and structural networks to reveal the role of tea drinking on brain organization.

The suppression of hemispheric asymmetry in the structural connectivity network was observed as a result of tea drinking.

The authors did not observe any significant effects of tea drinking on the hemispheric asymmetry of the functional connectivity network.

Dr. Junhua Li and Dr. Lei Feng said, "Tea has been a popular beverage since antiquity, with records referring to consumption dating back to the dynasty of Shen Nong (approximately 2700 BC) in China."

Tea is consumed in diverse ways, with brewed tea and products with a tea ingredient extremely prevalent in Asia, especially in China and Japan.

Although individual constituents of tea have been related to the roles of maintaining cognitive abilities and preventing cognitive decline, a study with behavioural and neurophysiological measures showed that there was a degraded effect or no effect when a constituent was administered alone and a significant effect was observed only when constituents were combined.

The superior effect of the constituent combination was also demonstrated in a comparative experiment that suggested that tea itself should be administered instead of tea extracts; a review of tea effects on the prevention of Alzheimers disease, found that the neuroprotective role of herbal tea was apparent in eight out of nine studies.

It is worth noting that the majority of studies thus far have evaluated tea effects from the perspective of neurocognitive and neuropsychological measures, with direct measurement of brain structure or function less-well represented in the extant literature.

These studies focusing on brain regional alterations did not ascertain tea effects on interregional interactions at the level of the entire brain.

The Li/Feng Research team concluded, "In summary, our study comprehensively investigated the effects of tea drinking on brain connectivity at both global and regional scales using multi-modal imaging data and provided the first compelling evidence that tea drinking positively contributes to brain structure making network organization more efficient."

Full Text - https://www.aging-us.com/article/102023/text

Correspondence to: Junhua Li email: junhua.li@essex.ac.uk and Lei Feng email: pcmfl@nus.edu.sg

Keywords: tea drinking, brain efficiency, fMRI, DTI, default mode network, hemispheric asymmetry

About Aging-US

Launched in 2009, Aging-US publishes papers of general interest and biological significance in all fields of aging research as well as topics beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, cancer, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR among others), and approaches to modulating these signaling pathways.

Please visit our website at http://www.Aging-US.com or connect with us on:

SoundCloud - https://soundcloud.com/Aging-Us
Facebook - https://www.facebook.com/AgingUS/
Twitter - https://twitter.com/AgingJrnl
Instagram - https://www.instagram.com/agingjrnl/
YouTube - https://www.youtube.com/agingus​
LinkedIn - https://www.linkedin.com/company/aging/
Pinterest - https://www.pinterest.com/AgingUS/

Aging-US is published by Impact Journals, LLC please visit http://www.ImpactJournals.com or connect with @ImpactJrnls

Media Contact
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Author Insight: Habitual Tea Drinking Modulates Brain Efficiency

FRITSCH Milling and Sizing

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Aging-US published this trending priority research paper on October 4, 2021, entitled, “Green tea catechins EGCG and ECG enhance the fitness and lifespan of Caenorhabditis elegans by complex I inhibition” by researchers from the Department of Human Nutrition, Institute of Nutrition, Friedrich Schiller University Jena, Germany; MOE Key Laboratory of Environment Correlative Dietology, College of Food Science and Technology, Huazhong Agricultural University, Wuhan, China; Laboratory of Energy Metabolism, Institute of Translational Medicine, Department of Health Sciences and Technology, Zurich, Schwerzenbach, Switzerland; Molecular Biology and Biochemistry, Gottfried Schatz Research Center, Medical University of Graz, Austria.

Abstract
Green tea catechins are associated with a delay in aging. We have designed the current study to investigate the impact and to unveil the target of the most abundant green tea catechins, epigallocatechin gallate (EGCG) and epicatechin gallate (ECG).

Experiments were performed in Caenorhabditis elegans to analyze cellular metabolism, ROS homeostasis, stress resistance, physical exercise capacity, health- and lifespan, and the underlying signaling pathways. Besides, we examined the impact of EGCG and ECG in isolated murine mitochondria.

A concentration of 2.5 μM EGCG and ECG enhanced health- and lifespan as well as stress resistance in C. elegans. Catechins hampered mitochondrial respiration in C. elegans after 6–12 h and the activity of complex I in isolated rodent mitochondria. The impaired mitochondrial respiration was accompanied by a transient drop in ATP production and a temporary increase in ROS levels in C. elegans. After 24 h, mitochondrial respiration and ATP levels got restored, and ROS levels even dropped below control conditions. The lifespan increases induced by EGCG and ECG were dependent on AAK-2/AMPK and SIR-2.1/SIRT1, as well as on PMK-1/p38 MAPK, SKN-1/NRF2, and DAF-16/FOXO. Long-term effects included significantly diminished fat content and enhanced SOD and CAT activities, required for the positive impact of catechins on lifespan.

In summary, complex I inhibition by EGCG and ECG induced a transient drop in cellular ATP levels and a temporary ROS burst, resulting in SKN-1 and DAF-16 activation. Through adaptative responses, catechins reduced fat content, enhanced ROS defense, and improved healthspan in the long term.

Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.203597

DOI - https://doi.org/10.18632/aging.203597

Full text - https://www.aging-us.com/article/203597/text

Correspondence to: Corina T. Madreiter-Sokolowski email: corina.madreiter@medunigraz.at and Michael Ristow email: michael-ristow@ethz.ch

Keywords: aging, reactive oxygen species, mitochondria, polyphenols, C. elegans

About Aging-US

Launched in 2009, Aging-US publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging-US go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways.

Please visit our website at http://www.Aging-US.com​​ or connect with us on:

Twitter - https://twitter.com/AgingJrnl
Facebook - https://www.facebook.com/AgingUS/
SoundCloud - https://soundcloud.com/aging-us​
YouTube - https://www.youtube.com/agingus​
LinkedIn -  https://www.linkedin.com/company/aging​

Aging-US is published by Impact Journals, LLC please visit http://www.ImpactJournals.com​​ or connect with @ImpactJrnls

Media Contact
18009220957
MEDIA@IMPACTJOURNALS.COM

Trending With Impact: Green Tea Enhances Fitness and Lifespan of C. Elegans

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Analytical Cannabis 

Speaking at The Science of Cannabis Extraction 2021 online symposium in June, Dr Brian Smith, Founder, CEO & Chief Technical Officer of Big Sur Scientific presented his recent research on THCA decarboxylation.

Abstract: We have discovered a new mechanism for THCA decarboxylation using mid-infrared spectroscopy to follow the reaction. Previous work on the gram scale showed a first order reaction rate limited by the concentration of THCA. Our work on the kilogram scale found the reaction is zeroth order and rate limited by the surface area of the vessel being used to heat the reactants. This discovery has important implications for how extractors can optimize their decarb reactions to save time and money.

THCA Decarboxylation: An Unexpected Mechanism

Speaking at The Science of Cannabis Extraction 2021 online symposium in June, Darwin Millard, Founder & Owner at The Spock of Cannabis, presented his interesting talk on infused products.

Abstract: Start-ups and established companies alike must have a good handle on their market growth in order to accurately anticipate when to expand their production capacity. Proper planning and execution are critical for avoiding costly capital expenditures that may never make a return on an investment. Each of these aspects of the manufacturing process has to be considered individually when designing the process train because each element will contribute to the system's output, either in a limiting or expansive capacity. This session will attempt to provide the audience with concepts they can utilize to properly generate a demand estimate and scale a process train to meet that demand.

Infused Products: Matching Level of Production to Market Demand

Speaking at The Science of Cannabis Extraction 2021 online symposium in June, Sabrina Didado, Founder & CEO of
Cosmic Harvest Hemp discussed the process and chemistry of supercritical CO2 extraction.

Abstract: This presentation will cover all the technical and chemical aspects behind supercritical carbon dioxide extraction in relation to the cannabis extraction process. It will cover the micro details regarding supercritical fluid, temperature, pressure, separating and why it is a superior process for cannabis extraction. The presentation will also cover the entire CO2 process from starting material (grinded/ decarb) through crude oil, all the way up to distillate, isolate and further cannabinoid conversion.

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Chromatography & Mass Spectrometry Solutions

Dr Joshua Coon of the University of Wisconsin-Madison discusses Lipidomics and small molecule characterization with the Thermo Scientific Orbitrap IQ-X Tribrid MS. Hear first-hand experience from an MS expert about how Real-Time Library Search improves confidence in identification, and how the sensitivity of the linear ion trap can improve detection of unknown compounds.

Small Molecule analysis and Lipidomics research on the Thermo Scientific Orbitrap IQ-X Tribrid MS

Dr Gary Patti, Washington University- St. Louis discusses Metabolomics and metabolites research and structural characterization of small molecules with the Thermo Scientific™ Orbitrap IQ-X™ Tribrid™ MS. Hear from a leader in the field how ultra-high resolution on an instrument dedicated for small molecules can improve your results.

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