Food and Beverage

Aging (Aging-US)

Aging-US published this research paper on October 26, 2023 in Volume 15, Issue 20, entitled, “Alcohol consumption and epigenetic age acceleration across human adulthood" by researchers from the Department of Biostatistics, Boston University School of Public Health, Boston, MA; Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL; Population Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD; Framingham Heart Study, Framingham, MA; Nutrition Epidemiology and Data Science, Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA.

DOI - https://doi.org/10.18632/aging.205153

Corresponding authors - Jiantao Ma - jiantao.ma@tufts.edu, and Chunyu Liu - liuc@bu.edu

Abstract

The alcohol-associated biological aging remains to be studied across adulthood. We conducted linear regression analyses to investigate the associations between alcohol consumption and two DNA methylation-based biological age acceleration metrics in 3823 Framingham Heart Study participants (24–92 years and 53.8% women) adjusting for covariates. We also investigated whether the two epigenetic aging metrics mediated the association of alcohol consumption with hypertension. We found that higher long-term average alcohol consumption was significantly associated with biological age acceleration assessed by GrimAge acceleration (GAA) and PhenoAge acceleration (PAA) in middle-aged (45–64 years, n = 1866) and older (65–92 years, n = 1267) participants while not in young participants (24–44 years, n = 690). For example, one additional standard drink of alcohol (~14 grams of ethanol per day) was associated with a 0.71 ± 0.15-year (p = 2.1e-6) and 0.60 ± 0.18-year (p = 7.5e-4) increase in PAA in middle-aged and older participants, respectively, but the association was not significant in young participants (p = 0.23). One additional standard serving of liquor (~14 grams of ethanol) was associated with a greater increase in GAA (0.82-year, p = 4.8e-4) and PAA (1.45-year, p = 7.4e-5) than beer (GAA: 0.45-year, p = 5.2e-4; PAA: 0.48-year, p = 0.02) and wine (GAA: 0.51-year, p = 0.02; PAA: 0.91-year, p = 0.008) in middle-aged participant group. We observed that up to 28% of the association between alcohol consumption and hypertension was mediated by GAA or PAA in the pooled sample. Our findings suggest that alcohol consumption is associated with greater biological aging quantified by epigenetic aging metrics, which may mediate the association of alcohol consumption with quantitative traits, such as hypertension.

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Keywords - aging, alcohol consumption, epigenetic aging, DNA methylation, hypertension

About Aging-US

Launched in 2009, Aging-US publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging-US go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways.

Please visit our website at https://www.Aging-US.com​​ and connect with us:

SoundCloud - https://soundcloud.com/Aging-Us
Facebook - https://www.facebook.com/AgingUS/
X - https://twitter.com/AgingJrnl
Instagram - https://www.instagram.com/agingjrnl/
YouTube - https://www.youtube.com/@AgingJournal
LinkedIn - https://www.linkedin.com/company/aging/
Pinterest - https://www.pinterest.com/AgingUS/

Media Contact
18009220957
MEDIA@IMPACTJOURNALS.COM

Alcohol Consumption and Epigenetic Age Acceleration Across Human Adulthood | Aging-US

BÜCHI Labortechnik AG

Are you tired of time-consuming and resource-draining quality control? NIR technology might be the solution you need! In this video, we'll show you how NIR can revolutionize your daily operations by allowing for fast and simultaneous determination of multiple parameters, saving you valuable time and resources.

By using NIR technology, you can quickly and accurately analyze samples to measure parameters such as moisture, fat content, protein levels, and many others. This eliminates bottlenecks and ensures that your products meet your desired standards.

So if you want to learn how to streamline your process and quality control operations, join us in this video and discover the power of NIR technology.

Food analysis technique with NIR ProxiMate™

Agilent Technologies

Take a musical journey through the challenges of sample preparation for small molecules, food testing, drug screening, and more. Each verse will show you how to go from sample preparation stress to success.

Stressed About Sample Prep? Agilent can help!

Creative Enzymes

Enzymes are known to aid food processing in a wide variety of applications, for example manufacturing of cheese, vinegar and wine; leavening of bread; brewing of beer and so on. In these processes enzymes help to save energy and resources, as well as improve the overall efficiency. In many instances, the use of enzymes has been proved to decrease the volumes and toxicity of byproducts and effluents. Creative Enzymes provides a wide range of products including high purity enzymes and custom blends, which can be readily used in food and beverage processes. https://www.creative-enzymes.com/cate/Food-And-Beverage-Applications_108.html

Enzymes in Food Industry

Brush up on your spray drying fundamentals! 
BUCHI Spray Drying Expert Deb Repko provides an overview of our new poster, The Art of Spray Drying, plus a palette of tips including: 
- The basics of spray drying 
- Designing particles and optimizing process parameters for success 
- How to save time and improve reproducibility 
- Automation possibilities with the new BUCHI Mini Spray Dryer S-300 

Watch now to start your own formulation masterpiece!

The Art of Spray Drying: Poster Overview

Aging-US published this research paper on June 9, 2023, in Volume 15, Issue 11, entitled, “Old-age-induced obesity reversed by a methionine-deficient diet or oral administration of recombinant methioninase-producing Escherichia coli in C57BL/6 mice" by researchers from AntiCancer Inc., San Diego, CA; Department of Surgery, University of California, San Diego, CA; Department of Medical Oncology, Division of Internal Medicine, Showa University School of Medicine, Tokyo, Japan.

DOI - https://doi.org/10.18632/aging.204783

Corresponding author - Robert M. Hoffman - all@anticancer.com

Abstract

Obesity increases with aging. Methionine restriction affects lipid metabolism and can prevent obesity in mice. In the present study we observed C57BL/6 mice to double their body weight from 4 to 48 weeks of age and become obese. We evaluated the efficacy of oral administration of recombinant-methioninase (rMETase)-producing E. coli (E. coli JM109-rMETase) or a methionine-deficient diet to reverse old-age-induced obesity in C57BL/6 mice. Fifteen C57BL/6 male mice aged 12–18 months with old-age-induced obesity were divided into three groups. Group 1 was given a normal diet supplemented with non-recombinant E. coli JM109 cells orally by gavage twice daily; Group 2 was given a normal diet supplemented with recombinant E. coli JM109-rMETase cells by gavage twice daily; and Group 3 was given a methionine-deficient diet without treatment. The administration of E. coli JM109-rMETase or a methionine-deficient diet reduced the blood methionine level and reversed old-age-induced obesity with significant weight loss by 14 days. There was a negative correlation between methionine levels and negative body weight change. Although the degree of efficacy was higher in the methionine-deficient diet group than in the E. coli JM109-rMETase group, the present findings suggested that oral administration of E. coli JM109-rMETase, as well as a methionine-deficient diet, are effective in reversing old-age-induced obesity. In conclusion, the present study provides evidence that restricting methionine by either a low-methionine diet or E. coli JM109-rMETase has clinical potential to treat old-age-induced obesity.

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Keywords - aging, obesity, methionine restriction, methionine-deficient diet, recombinant methioninase (rMETase), Escherichia coli, microbiome, weight-loss

About Aging-US

Launched in 2009, Aging-US publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging-US go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways.

Please visit our website at https://www.Aging-US.com​​ and connect with us:

SoundCloud - https://soundcloud.com/Aging-Us
Facebook - https://www.facebook.com/AgingUS/
Twitter - https://twitter.com/AgingJrnl
Instagram - https://www.instagram.com/agingjrnl/
YouTube - https://www.youtube.com/@AgingJournal
LinkedIn - https://www.linkedin.com/company/aging/
Pinterest - https://www.pinterest.com/AgingUS/

Media Contact
18009220957
MEDIA@IMPACTJOURNALS.COM

Reversing Old-Age Obesity in Mice: Methionine-Deficient Diet & Methioninase E. coli

In this video, we demonstrate the revolutionary Zero Tube Movement Principle in Kjeldahl nitrogen determination method, showcasing a safer and more efficient workflow for the digestion, distillation, titration, and cleaning processes in TKN (Total Kjeldahl Nitrogen) determination.

The Zero Tube Movement Principle eliminates the need to handle individual sample tubes throughout the analysis, significantly improving safety and reducing the risk of accidents. By keeping the samples securely contained in a specially designed rack, we ensure a controlled environment while streamlining the workflow.

The sample tubes are initially placed in the rack, which is then transferred to the digester for the digestion process. This step ensures thorough decomposition of samples while maintaining their integrity.

Once the digestion is complete, the rack is placed into the autosampler and the samples are smoothly transferred via steam to the distillation unit. This innovative technique allows for the quick and easy transfer of samples from the rack to the distillation unit, eliminating the need to handle individual glass sample tubes. This seamless automation of this step enables saving time and reduces the risk of human error.

Furthermore, as the analysis nears completion, the sample tubes within the rack are prepared for cleaning using the retaining plate. This ensures efficient and uniform cleaning of the tubes, promoting consistency in subsequent analyses. Finally, the sample tubes are effortlessly loaded into the dish washer, simplifying the cleaning process and preparing them for future use.

Join us in embracing the Zero Tube Movement Principle, a groundbreaking approach that enhances laboratory safety, streamlines workflows, and optimizes productivity. Subscribe to our channel for more exciting videos showcasing the latest advancements in laboratory techniques and equipment. Stay tuned for more informative content on innovations for your workflow!


Revolutionizing Kjeldahl Nitrogen Determination Method with Zero Tube Movement

Is your manufacturing QC team struggling with an overly lean workforce, hazardous chemical exposure, or slow quality feedback loops? 

Near-infrared (NIR) spectroscopy is a proven technique that can help you avoid the common pitfalls of traditional quality control modalities. But how? 

In this video we unpack how QC labs can do more with their current headcount, improve workplace safety while enhancing efficiency, and avoid product rework and recalls using NIR.

Ditch Traditional QC for NIR: Why, and How to Find Your Best Fit

FRITSCH Milling and Sizing

In this video we show our FRITSCH high-performance Cyclone Separator in combination with our [/name] [url][link]https://www.fritsch-international.com/sample-preparation/milling/cutting-mills/details/product/pulverisette-19-300-3000-rpm/ [/link][name] PULVERISETTE 19[/name][/url]. The patented combination of the universal cutting mill with the high-performance cyclones enables easier cleaning and filling, the use of finer sieve cassettes for higher final finenesses, accelerates the throughput, and keeps the thermal load on the samples low - even with materials that are otherwise difficult to finely grind.

Detailed info about our Cyclone separator: [url][link] https://www.fritsch-international.com/sample-preparation/milling/cutting-mills/details/product/pulverisette-19-300-3000-rpm/accessories/ [/link][name] FRITSCH high-performance Cyclone Seperator [/name][/url]

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