Biopharma

Lonza

Advance your in vitro drug interaction studies to the next level! Watch this video to learn how our Interaction Qualified primary hepatocytes can increase your confidence in your DDI and metabolism studies.

Learn more about Interaction Qualified Primary Hepatocytes: https://bioscience.lonza.com/lonza_bs/US/en/interaction-qualified-hepatocytes


Learn how Lonza can support your liver research applications: https://bioscience.lonza.com/liver-studies-for-adme-tox-studies

Cryopreserved primary hepatocytes products from Lonza: https://bioscience.lonza.com/Catalogue/Products/ADME-and-Toxicology/c/5?q=%3A%3A%3A%3Alonza-sort%3A%3A%3A%3Alon_cl_PrimaryCellType%3A%3A%3A%3AHepatocytes
#ADME #Toxicology #Drugmetabolism #pharmacokinetic #DrugDiscovery #hepatocytes #primarycells #FDA #Lonza #DrugDrugInteraction #DDI

Interaction Qualified Primary Hepatocytes | Lonza Product Overview

BÜCHI Labortechnik AG

Gain valuable information on spray drying theory and applications. Two experts in the field cover topics such as:

- Comprehensive overview of the spray drying and encapsulation process
- Your spray dryer: how it works, how to use it, how to maintain it
- Tips for improving your spray drying parameters
- Spray drying for different applications

How to optimize your spray drying process

Sekisui XenoTech

Presenter: Pallavi Limaye, Ph.D., DABT, SEKISUI XenoTech Director of Scientific Consulting

Abstract:
Aldehyde oxidase (AO) enzyme has gained increasing attention in drug development as one of the alternative approaches to reduce P450-mediated drug metabolism liability. However, clinical failure due to poor prediction of AO-mediated clearance is a major hurdle in development of drugs that are AO substrates. In vitro to in vivo extrapolation underpredicts AO-mediated drug clearance owing to several factors including lack of reliable representative animal models, marked species differences, significant inter-individual variability, substrate-specific activity, and discrepancy between absolute concentration and activity. To tackle these issues related to underprediction of AO-mediated drug clearance, in vitro tools to extrapolate in vivo clearance involving a yardstick approach are proposed. AO-metabolism is an attractive strategy to reduce P450-mediated drug metabolism liability but careful consideration of the unique challenges is essential.

Key concepts discussed in this webinar will include:
 - Wide range of AO substrates – Functional groups
 - AO substrate drugs that faced clinical failure unanticipated drug clearance
 - Underprediction and Factors affecting AO expression
   - Age, Disease state, Alcohol consumption, Pharmacogenomics
   - Species differences
   - Inter-individual variability
   - Sample handling, Freeze-thaw cycles, Fresh vs. Frozen tissue
 - In vitro AO inhibition and fm AO determination
 - In vitro yardstick approach

Request a copy of the slides: https://www.xenotech.com/about/events/webinar-underprediction-of-drug-clearance-by-aldehyde-oxidase-ao-mediated-drug-metabolism-important-considerations-for-in-vitro-assessment/
Questions, comments and requests: https://www.xenotech.com/contact/
More information on our research services and test systems: https://www.xenotech.com
Other previously aired webinars: https://www.xenotech.com/access-adme-research-resources/resource-type/webinar/
Upcoming webinar notifications: https://www.xenotech.com/contact/newsletter-sign-up/
Request a webinar topic: https://www.xenotech.com/contact/webinar-seminar-request/

About the Presenter:
Pallavi Limaye is a Director in the Scientific Consulting department. Pallavi received her Ph.D. in Toxicology from The University of Louisiana. Dr. Limaye originally joined SEKISUI XenoTech in 2011 as a Research Scientist and served as a study director for in vitro drug metabolism studies. In 2020, she joined SEKISUI XenoTech’s consulting team and provides input on drug-drug interaction study needs for sponsors. Dr. Limaye has published several original research articles in various journals and has also contributed many book chapters in the field of toxicology and liver pathobiology. She is also actively involved in scientific societies and currently serves on the E-Learning Subcommittee of The American College of Toxicology and is the current President of the Central States regional chapter of The Society of Toxicology.

Underprediction of Drug Clearance by Aldehyde Oxidase (AO)–Mediated Drug Metabolism (Webinar)

Chromatography & Mass Spectrometry Solutions

Get more from your enzyme method development process—starting with walkaway efficiency. The Thermo Scientific™ Gallery™ Enzyme Master enzyme analyzers are the first automated enzyme analyzers designed specifically for enzyme assay applications. Combining robust hardware and new custom designed software, these best-in-class solutions deliver fully-automated incubation settings, reagent additions, and precise measurement calculations—all with a touch of a button. They offer the smartest (and fastest) way yet to streamline method development and deliver reliable results.

Fully-automated enzyme assay analysis

Mutant library

With years of experience in research of oncolytic viruses as well as our QVirusTM platform, Creative Biogene expeditiously moves your oncolytic program forward for initial early-stage clinical evaluation.  Creative Biogene provides a broad range of oncolytic virus engineering scope including herpes simplex virus, adenovirus, measles virus, vaccinia virus, vescilar stomatitis virus, and so on.

https://www.creative-biogene.com/Services/Custom-Viral-Service/Oncolytic-Virus-service.html

Oncolytic Virotherapy

Creative Bioarray

Drug permeability is one of the most important factors to be considered for predicting drug oral bioavailability. During the early discovery and development phase, drug candidates are screened to select candidates that have better oral-absorption potential. Then a filter is applied to remove poor performers and identify candidates that need to be modified.

https://www.creative-bioarray.com/Services/pampa-assay.htm

PAMPA Permeability Assay

With our over 10 years' experiences of working with tumor cell lines, Creative Bioarray provides cell proliferation assay service for our customers. We provide optional assay methods based on the cell type and protocol, and on the customer’s preference of proliferation measurement.

https://www.creative-bioarray.com/Services/cell-proliferation-assay-services.htm

Cell Proliferation Assay

Creative Bioarray provides Cell Cycle Analysis Service for all of our customers.

The technique Creative Bioarray uses is flow cytometry measuring cellular DNA content.

https://www.creative-bioarray.com/cell-cycle-assays.htm

Cell Cycle Assays

Learn about the innovative features of the Thermo Scientific Vanquish Neo UHPLC system - the new standard in low-flow UHPLC

Biopharma

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