Bioengineering

Creative Bioarray

Creative Bioarray is an experienced and outstanding provider of stem cell research service. We are dedicated to providing detailed data and comprehensive service for your scientific research, and we are pleased to use our extensive experience and advanced platform to offer the best service to satisfy each demand from our customers.

https://www.creative-bioarray.com/services/stem-cell-research.htm

Stem Cell Research

Creative Bioarray is a reliable Parallel Artificial Membrane Permeability Assay (PAMPA) provider. Over the past years, Creative Bioarray has developed expertise in PAMPA. By working with a variety of customers, we can perfectly meet your project requirements and budgets.

https://www.creative-bioarray.com/Services/pampa-assay.htm

PAMPA Permeability Assay

Creative Bioarray provides Cell Apoptosis Assays to all of our customers. The process of programmed cell death, or apoptosis, is generally characterized by distinct morphological characteristics and energy-dependent biochemical mechanisms.

https://www.creative-bioarray.com/cell-apoptosis-assays.htm

Cell Apoptosis

Creative Biolabs

Creative Biolabs, established in the US, is a leading contract service provider of bispecific antibody discovery and engineering. 
https://www.creative-biolabs.com/bsab/

Your Professional Antibody Solution Provider—Creative Biolabs

Mutant library

Creative Biogene provides world-class packaging services for a variety of viral types using our QVirusTM platform. Our custom viral services are highlighted by a consistent high titer and large delivery viral counts.

https://qvirus.creative-biogene.com/

QVirus Platform

Gene knockout cell line generation service, ranging from tumor cell line to difficult-to-handle cell line.

https://www.creative-biogene.com/crispr-cas9/

CRISPR Application

Creative Biogene is a biotechnology company specializing in custom baculovirus production service. Our advanced technologies and highly experienced staffs are available to assist in all aspects of baculovirus transfer vector construction, recombinant bacmid DNA preparation, as well as the generation of the baculovirus in high titer.

https://www.creative-biogene.com/support/Baculovirus-Efficient-Tool-for-Protein-Expression.html

Baculovirus-Efficient Tool for Protein Expression

Biotech Videos 

The 2021 Creative Biolabs Scholarship Acceptance Speech
https://www.creative-biolabs.com/scholarship-program.html

The 2021 Creative Biolabs Scholarship Acceptance Speech

Oncotarget

Oncotarget recently published "Evaluations of CRC2631 toxicity, tumor colonization, and genetic stability in the TRAMP prostate cancer model" which reported that the toxicological, tumor-targeting, and efficacy profiles of Salmonella enterica serovar Typhimurium CRC2631 in a syngeneic and autochthonous TRAMP model of aggressive prostate cancer.

CRC2631 preferentially colonize primary and metastatic tumors in the TRAMP animals.

In addition, longitudinal whole genome sequencing studies of CRC2631 recovered from prostate tumor tissues demonstrate that CRC2631 is genetically stable.

Combination of CRC2631 with checkpoint blockade reduces metastasis burden.

Collectively, these Oncotarget findings demonstrate a potential for CRC2631 in cancer immunotherapy strategies.

Dr. Yves C. Chabu from The University of Missouri said, "Conventional cancer chemotherapies are not specific and, as such, generate significant morbidities."

Several bacterial strains have been developed, including the Salmonella enterica serovar Typhimurium strain VNP20009, one of the most studied tumor-targeting strains.

VNP20009 was first isolated in a genetic screen for hyper invasion mutants using a library of mutant strains derived from ultraviolet and chemical mutagenesis of strain 14028.

CRC2631 was derived from a parent strain that was derived from the prototrophic wild-type Salmonella typhimurium LT2 strain.

This collection consists of mutant strains that arose naturally under nutrient-limiting conditions for over four decades, generating a wealth of genetically diverse and potentially attenuated strains.

Similar to prostate cancers in men, these murine carcinomas disseminate throughout visceral organs, differentiate into neuroendocrine prostate cancer, and ultimately kill the host.

The Chabu Research Team concluded in their Oncotarget Research Paper, "Importantly, CRC2631 reduced metastasis incidence in the setting of checkpoint blockade. This is significant because metastasis is the main cause of cancer-associated deaths and no effective immunotherapy against prostate cancer currently exist."

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DOI - https://doi.org/10.18632/oncotarget.2...

Full text - https://www.oncotarget.com/article/27...

Correspondence to - Yves C. Chabu - chabuc@missouri.edu

Keywords - salmonella, cancer targeting, prostate cancer, immunotherapy, TRAMP

About Oncotarget

Oncotarget is a bi-weekly, peer-reviewed, open access biomedical journal covering research on all aspects of oncology.

To learn more about Oncotarget, please visit https://www.oncotarget.com or connect with:

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Oncotarget is published by Impact Journals, LLC please visit https://www.ImpactJournals.com or connect with @ImpactJrnls

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Bioengineering

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