Automation

Chromatography & Mass Spectrometry Solutions

The sample preparation workflow for pesticide analysis can be accelerated through automation with possible on-line or off-line injection into the chromatographic system. The video focuses on the automated clean-up step of QuEChERS extracts through the microSPE technology using the Thermo Scientific™ TriPlus™ RSH or RSH SMART autosamplers. The automated workflow is compliant with SANTE guidelines in terms of recovery, precision and sensitivity for hundreds of pesticides. Nevertheless, the programming capability of the robotic autosampler allows more. Automation can be extended including calibration standards preparation, achieving full benefits in terms of labor time and cost saving. The automation and the miniaturization also offers to laboratories a green approach, by scaling down sample and solvent consumption. Additionally, the new TriPlus RSH SMART autosampler enables the automatic syringe identification and usage tracking to enhance consumables management and GLP operations. 

Thermo Scientific TriPlus RSH microSPE workflow. On-line clean-up of QuEChERS extracts for GC-MS analysis

Aging (Aging-US)

*Visit here for a transcript of this interview: https://aging-us.net/2022/06/22/longevity-aging-series-ep-1-drs-alex-zhavoronkov-and-frank-pun/

Aging (Aging-US) and FOXO Technologies have teamed up to present a special collaboration on aging research with a new monthly video series: the Longevity & Aging Series. This series of video interviews invites Aging researchers to speak with researcher and host Dr. Brian Chen. Dr. Chen is an adjunct faculty member at the Herbert Wertheim School of Public Health and Human Longevity Science at the University of California San Diego. He is also the Chief Science Officer of FOXO Technologies. 

In the first episode of the Longevity & Aging Series, Drs. Alex Zhavoronkov and Frank Pun discuss, in detail, their recently published research paper, “Hallmarks of aging-based dual-purpose disease and age-associated targets predicted using PandaOmics AI-powered discovery engine.” 

DOI - https://doi.org/10.18632/aging.203960

Corresponding author - Alex Zhavoronkov - alex@insilico.com

Abstract

Aging biology is a promising and burgeoning research area that can yield dual-purpose pathways and protein targets that may impact multiple diseases, while retarding or possibly even reversing age-associated processes. One widely used approach to classify a multiplicity of mechanisms driving the aging process is the hallmarks of aging. In addition to the classic nine hallmarks of aging, processes such as extracellular matrix stiffness, chronic inflammation and activation of retrotransposons are also often considered, given their strong association with aging. In this study, we used a variety of target identification and prioritization techniques offered by the AI-powered PandaOmics platform, to propose a list of promising novel aging-associated targets that may be used for drug discovery. We also propose a list of more classical targets that may be used for drug repurposing within each hallmark of aging. Most of the top targets generated by this comprehensive analysis play a role in inflammation and extracellular matrix stiffness, highlighting the relevance of these processes as therapeutic targets in aging and age-related diseases. Overall, our study reveals both high confidence and novel targets associated with multiple hallmarks of aging and demonstrates application of the PandaOmics platform to target discovery across multiple disease areas.

Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.203960

Press release - https://aging-us.net/2022/06/22/aging-aging-us-and-foxo-present-the-longevity-aging-series/

Keywords - aging, artificial intelligence, deep learning, drug discovery, multi-omics, target identification

About Aging-US

Launched in 2009, Aging-US publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging-US go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways.

Please visit our website at http://www.Aging-US.com​​ or connect with us:

SoundCloud - https://soundcloud.com/Aging-Us
Facebook - https://www.facebook.com/AgingUS/
Twitter - https://twitter.com/AgingJrnl
Instagram - https://www.instagram.com/agingjrnl/
YouTube - https://www.youtube.com/agingus​
LinkedIn - https://www.linkedin.com/company/aging/
Pinterest - https://www.pinterest.com/AgingUS/

Aging-US is published by Impact Journals, LLC: http://www.ImpactJournals.com​​

Media Contact
18009220957
MEDIA@IMPACTJOURNALS.COM

Longevity & Aging Series (EP 1): Dr. Alex Zhavoronkov and Dr. Frank Pun

Teach Me in 10

In this Teach me In 10 episode we are joined by Nicky Keay, a leading expert in endocrinology and honorary clinical lecturer in medicine at UCL, honorary fellow in the Department of Sport and Exercise Sciences at Durham University, and former research fellow at St. Thomas’ Hospital. 

Dr. Keay will be teaching us about personalizing female hormone health, and how applying artificial intelligence to modeling female hormones enables women to access hormone intelligence at their fingertips.

Female Hormone Mapping With Dr. Nicky Keay

See how the Gallery Enzyme Master enzyme analyzer will automate your workflow and give you the ability to provide parallel optimal pH measurements, full traceability, and reliable method development and transferability.

Fully-automate enzyme assay analysis

Next-generation sequencing (NGS) target enrichment methods provide solutions to focus on and sequence a small portion of the human genome. This saves sequencing and analysis costs for labs that study genetic diseases. These savings typically range from approximately 100 to 100,000 fold, depending on the application and the amount of the genome being targeted. Until now, there have been two primary target enrichment methods used in the field.
 Hybridization capture methods are considered high-performance solutions that tend to require cumbersome steps and an overnight hybridization incubation for optimal performance. On the other hand, amplicon technologies are considered fast and easy but generally do not have the same level of performance compared to capture technologies. Primer Extension Target Enrichment (PETE) is a newly developed technology that uses DNA polymerase extension reactions to provide a high-performance target enrichment solution that is easy to use and can be performed in a single day. 

In this Teach Me in 10, Brian Godwin, director of reagent and assay development at Roche sequencing, joins Lucy Lawrence to give us an overview of how each of the three target enrichment technologies work along. Godwin also shares a description of common target enrichment performance metrics.

Introducing Primer Extension Target Enrichment for NGS With Brian Godwin

Dr. Frank Pun, Associate Director (Project & Operations) and Application Science Lead at Insilico Medicine in Hong Kong, describes his experience publishing a research paper that he co-authored, entitled, “Hallmarks of aging-based dual-purpose disease and age-associated targets predicted using PandaOmics AI-powered discovery engine” with Aging (Aging-US).

DOI - https://doi.org/10.18632/aging.203960

Corresponding author - Alex Zhavoronkov - alex@insilico.com

Abstract
Aging biology is a promising and burgeoning research area that can yield dual-purpose pathways and protein targets that may impact multiple diseases, while retarding or possibly even reversing age-associated processes. One widely used approach to classify a multiplicity of mechanisms driving the aging process is the hallmarks of aging. In addition to the classic nine hallmarks of aging, processes such as extracellular matrix stiffness, chronic inflammation and activation of retrotransposons are also often considered, given their strong association with aging. In this study, we used a variety of target identification and prioritization techniques offered by the AI-powered PandaOmics platform, to propose a list of promising novel aging-associated targets that may be used for drug discovery. We also propose a list of more classical targets that may be used for drug repurposing within each hallmark of aging. Most of the top targets generated by this comprehensive analysis play a role in inflammation and extracellular matrix stiffness, highlighting the relevance of these processes as therapeutic targets in aging and age-related diseases. Overall, our study reveals both high confidence and novel targets associated with multiple hallmarks of aging and demonstrates application of the PandaOmics platform to target discovery across multiple disease areas.

Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.203960

Keywords - aging, artificial intelligence, deep learning, drug discovery, multi-omics, target identification

About Aging-US

Launched in 2009, Aging-US publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging-US go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways.

Please visit our website at http://www.Aging-US.com​​ or connect with us:

SoundCloud - https://soundcloud.com/Aging-Us
Facebook - https://www.facebook.com/AgingUS/
Twitter - https://twitter.com/AgingJrnl
Instagram - https://www.instagram.com/agingjrnl/
YouTube - https://www.youtube.com/agingus​
LinkedIn - https://www.linkedin.com/company/aging/
Pinterest - https://www.pinterest.com/AgingUS/

Aging-US is published by Impact Journals, LLC: http://www.ImpactJournals.com​​

Media Contact
18009220957
MEDIA@IMPACTJOURNALS.COM

Author Testimonial: Dr. Frank Pun - Insilico Medicine

SCP SCIENCE CHANNEL

MiniWAVE est un système de minéralisation par micro-ondes compact à chargement vertical composé d’un contrôleur à écran tactile et jusqu’à 4 modules de minéralisation interconnectés. Le système est conçu pour les petits laboratoires afin d’augmenter leur productivité et offre une sélection de méthode flexible pour de nombreux types d’échantillons différents.

Publicité commerciale de MiniWAVE

L’EasyPREP TitrEC par SCP SCIENCE automatise les mesures de pH, de conductivité et d’alcalinité pour gagner du temps et libérer la main-d’œuvre. Le système mesure également la turbidité selon des méthodes standards.

Publicité commerciale de EasyPREP TitrEC

L’EasyPREP Soil Analyzer par SCP est conçu pour des laboratoires agricoles et biochimiques pour automatiser les mesures de pH et d’électroconductivité d’échantillons de sol dans une variété de récipients.

Automation

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