Analytical Techniques

Wyss Institute for Biologically Inspired Engineering at Harvard University

Melanoma is a very severe cancer that is often diagnosed too late to save patients' lives, and most people do not regularly visit a dermatologist for skin exams. Early-stage identification of suspicious pigmented lesions (SPLs), ideally by primary care providers, could lead to improved melanoma prognosis. Researchers at the Wyss Institute and MIT have developed a deep learning algorithm that can differentiate SPLs from non-cancerous skin marks in wide-field images of patients' skin, such as those taken with a tablet or cellphone. This method could enable improved patient triaging, reduced medical costs, and earlier treatment of melanoma.

For more information, please visit: https://wyss.harvard.edu/news/identifying-ugly-ducklings-to-catch-skin-cancer-earlier/

Credit: Wyss Institute at Harvard University

Using deep learning to detect cancerous skin lesions

BÜCHI Labortechnik AG

Learn how to implement a fast and fully compliant SOP for testing of pharmaceuticals in your laboratory with our free webinar. Topics include:
💊 Aspects for 21 CFR Part 11 compliance
💊 How to perform nitrogen determination-based quality testing of pharmaceutical substances
💊 Three steps needed to establish a time-efficient SOP
💊 Real-life example of how Sanofi has optimized their QC process by using a nitrogen determination method

How to achieve compliance in QC of nitrogen-containing compounds

Teach Me in 10

This instalment of Teach Me in 10 features [url][link]https://aru.ac.uk/people/lorna-nisbet[/link][name]Dr Lorna Nisbet[/name][/url], a senior lecturer at Anglia Ruskin University. Lorna’s research interests are within the field of forensic toxicology where she specializes in the detection of new psychoactive substances that have been chemically altered to produce new types of high. She speaks candidly on prison population drug outbreaks and how her work develops ways to detect the new psychoactive substances you may in this environment and within hospital admissions. Watch Lorna’s Teach Me in 10 to discover how she is able to discover new psychoactive substances in the population and how her work links to the detection of new psychoactive substances reported to the EU each year.

Detecting Psychoactive Substances in Forensic Toxicology

FRITSCH Milling and Sizing

Organic materials for example vegetables and fruit can be effectively comminuted in liquid nitrogen with the Knife Mill. View what accessories you need to conduct this process. If you would like to read more about our Laboratory Knife Mill visit our website:
[url][link] https://www.fritsch-international.com/sample-preparation/milling/knife-mill/details/product/pulverisette-11/ [/link][name]Knife Mill PULVERISETTE 11[/name][/url]

PROCESSING ORGANIC MATERIAL IN LIQUID NITROGEN WITH THE KNIFE MILL PULVERISETTE 11

Our lab manager Leos Benes will show you how to conduct a wet sieving of sand with our Vibratory Sieve Shaker ANALYSETTE 3 PRO. 
Detailed info: [url][link] https://www.fritsch-international.com/sample-preparation/sieving/vibratory-sieve-shakers/details/product/analysette-3-pro/[/link][name]Vibratory Sieve Shaker ANALYSETTE 3 PRO[/name][/url]

Wet sieving with the Vibratory Sieve Shaker ANALYSETTE 3 PRO

Chromatography & Mass Spectrometry Solutions

Just when you thought it couldn’t be done, the Thermo Scientific Neoma MC-ICP-MS raises the bar. It creates higher precision for the same sample size. Less material is required for analysis, so less time is spent on selecting the foraminifera, and you can look at other sea floor records that contain very low amounts of specific foraminifera species.

Climate Change Research with Neoma MC-ICP-MS

For scientists whose research requires high-precision isotope ratio data in fields of cosmo- and geochemistry, geochronology and biology, nuclear safeguards, forensics, metalomics, and provenance studies, we have created a new multicollector ICP-MS. Designed and developed in Bremen, building on the strengths of our multi-collector platform with field-proven technologies such as RPQ, 10^13 ohm Amplifier Technology and Jet Interface.

Making of Neoma MC-ICP-MS

Analytical Cannabis 

Speaking at the Analytical Cannabis Expo East Online 2020 in October, Mike Esposito, Scientist I at MCR Labs presented his talk on microbiological testing of cannabis.

Humans have been enumerating microorganisms since 1878, and in the nearly 150 year history of enumeration, incredible new techniques and technologies have been implemented to both simplify and increase the accuracy of our microbial counting methods. While these techniques range in complexity from counting cells under a microscope to quantifying DNA extracted from a microbe, they all have their own distinct advantages and challenges. In this talk we will take a look at historical strategies, contemporary approaches, and up and coming technologies that we can look forward to. We will discuss shortcomings of traditional methods, like the difficulties of counting dense colonies on a plate and the slow turn-around of test results due to incubations, as well as describing the advantages of these techniques, such as robust validation and decades of implementation that make these techniques the “golden standard”. Additionally, we will look at new technologies like micro-arrays and qPCR that aim to eliminate issues with turnaround time and off-target ennumeration, but come with their own host of issues such as highly variable extraction efficiencies and the rarely discussed topic of copy number variation in some gene targets. Lastly, we will look at adaptations to culture-based and PCR based methods, such as the widely used most probable number technique, and the up and coming droplet digital PCR technology that will look to combine the speed of qPCR with the accuracy of most probable number testing.

Challenges to Microbiological Enumeration

Speaking at the Analytical Cannabis Expo East Online 2020 in October, Josh Smith, CEO & Chief Scientist at Premium CBD Labs, presented his talk on microbial testing of cannabis.

Microbial Testing requirements vary in the US from state to state and the type of cannabis your crop or product is derived from. From overly generic such as “total aerobic” to using DNA based methods to test for E. coli O157:H7 and even all the way to …. nothing at all. Why do these tests matter, what do they actually tell you and how did the states decide on them? In the end, do they make sense? When a major problem with the cannabis industry is a resurgence of the black market and compliance costs for legal products, it’s worth reviewing these kinds of requirements and asking if we have picked the right monitoring tests to make these products safe for consumption.

Analytical Techniques

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