Chemistry

BÜCHI Labortechnik AG

Learn how to use steam distillation to determine essential oils in juice🥤 in less than 1 minute. See the process for analysis of D-Limonene levels, as the major constituent of citrus essential oils, and an appropriate quality indicator. The method shown is  compliant to IFU method No. 45 and AOAC 968.20. The steam distillation process includes these steps:
- Steam distillation into an aqueous solution of HCl and methyl orange indicator
- Titration with KBr / KBrO₃ solution while using an optical electrode yields the amount of D-Limonene

❗ For more information:
- Application Note: https://bit.ly/3fPtKNA
- Product information: https://bit.ly/3rF5ovt

Method for essential oil determination in juice in 1 minute

Aging (Aging-US)

Aging (Aging-US) published this research paper in Volume 11, Issue 18, entitled, "Inadequate control of thyroid hormones sensitizes to hepatocarcinogenesis and unhealthy aging" by researchers from the Department of Regeneration and Cell Therapy, Andalusian Center for Molecular Biology and Regenerative Medicine-CABIMER, Junta de Andalucia-University of Pablo de Olavide-University of Seville-CSIC, Seville, Spain; Instituto de la Grasa (CSIC), Universidad Pablo de Olavide, Sevilla, Spain; Centro de Investigación Príncipe Felipe, Valencia, Spain; Department of Human Physiology, Málaga University, Biomedical Research Institute of Málaga (IBIMA), Málaga, Spain; Instituto de Investigación Biomédica de Málaga-IBIMA, UGC Endocrinología y Nutrición. Hospital Regional Universitario de Málaga, Málaga, Spain; Biomedical Research Network on Diabetes and Related Metabolic Diseases-CIBERDEM, Instituto de Salud Carlos III, Madrid, Spain; Centro Andaluz de Biología del Desarrollo, Universidad Pablo de Olavide and CIBERER, Sevilla, Spain; Department of Physiology, University Miguel Hernández School of Medicine Sant Joan d'Alacant, Alicante, Spain.

DOI - https://doi.org/10.18632/aging.102285

Correspondence to - Alejandro Martin-Montalvo - alejandro.martinmontalvo@cabimer.es and Benoit Raymond Gauthier - benoit.gauthier@cabimer.es

Abstract:
An inverse correlation between thyroid hormone levels and longevity has been reported in several species and reduced thyroid hormone levels have been proposed as a biomarker for healthy aging and metabolic fitness. However, hypothyroidism is a medical condition associated with compromised health and reduced life expectancy. Herein, we show, using wild-type and the Pax8 ablated model of hypothyroidism in mice, that hyperthyroidism and severe hypothyroidism are associated with an overall unhealthy status and shorter lifespan. Mild hypothyroid Pax8 +/- mice were heavier and displayed insulin resistance, hepatic steatosis and increased prevalence of liver cancer yet had normal lifespan. These pathophysiological conditions were precipitated by hepatic mitochondrial dysfunction and oxidative damage accumulation. These findings indicate that individuals carrying mutations on PAX8 may be susceptible to develop liver cancer and/or diabetes and raise concerns regarding the development of interventions aiming to modulate thyroid hormones to promote healthy aging or lifespan in mammals.

Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.102285

Press release - https://www.aging-us.com/news_room/inadequate-control-of-thyroid-hormones-sensitizes-to-hepatocarcinogenesis-and-unhealthy-aging

Keywords - lifespan, healthspan, thyroid hormones, hyperthyroidism, hypothyroidism, glucose metabolism

About Aging-US

Launched in 2009, Aging-US publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging-US go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways.

Please visit our website at http://www.Aging-US.com​​ or connect with us:

SoundCloud - https://soundcloud.com/Aging-Us
Facebook - https://www.facebook.com/AgingUS/
Twitter - https://twitter.com/AgingJrnl
Instagram - https://www.instagram.com/agingjrnl/
YouTube - https://www.youtube.com/agingus​
LinkedIn - https://www.linkedin.com/company/aging/
Pinterest - https://www.pinterest.com/AgingUS/

Aging-US is published by Impact Journals, LLC: http://www.ImpactJournals.com​​

Media Contact
18009220957
MEDIA@IMPACTJOURNALS.COM

Paper Spotlight: Modulation of Thyroid Hormones Leads to Unhealthy Aging

Oncotarget

Dr. Sridhar Mani from Medicine and Genetics of The Albert Einstein College of Medicine, Bronx, NY, details his editorial published by Oncotarget in Volume 11, Issue 19, entitled, “Microbial metabolite mimicry: one step closer to drug discovery.”

DOI - https://doi.org/10.18632/oncotarget.27591

Correspondence to - Sridhar Mani - sridhar.mani@einsteinmed.org

Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.27591

Keywords - microbial metabolites, inflammation, IBD, mimicry, drugs

About Oncotarget

Oncotarget is a peer-reviewed, open access biomedical journal covering research on all aspects of oncology.

To learn more about Oncotarget, please visit https://www.oncotarget.com or connect with:

SoundCloud - https://soundcloud.com/oncotarget
Facebook - https://www.facebook.com/Oncotarget/
Twitter - https://twitter.com/oncotarget
Instagram - https://www.instagram.com/oncotargetjrnl/
YouTube - https://www.youtube.com/c/OncotargetYouTube/
LinkedIn - https://www.linkedin.com/company/oncotarget
Pinterest - https://www.pinterest.com/oncotarget/
Reddit - https://www.reddit.com/user/Oncotarget/

Oncotarget is published by Impact Journals, LLC please visit https://www.ImpactJournals.com or connect with @ImpactJrnls

Media Contact
MEDIA@IMPACTJOURNALS.COM
18009220957

Author Insight: Microbial Metabolite Mimicry May Improve Drug Discovery

SiliCycle Inc.

This Q&A video will show you the two different ways to determine how much scavenger will be needed in your purification based on your solution parameters.

What are metal scavengers?
Metal Scavengers are functionalized silica gels designed to react and bind metal complexes. They are used to remove metallic impurities from your chemistry.

Metal scavengers are offered in various formats:

- as bulk (SiliaMetS functionnalized silica gels)
https://www.silicycle.com/products/metal-scavengers

- packed in "flash" cartridges (SiliaSep)
https://www.silicycle.com/products/siliasep-flash-cartridges

- packed in SPE cartridges (SiliaPrep)
https://www.silicycle.com/products/silicycle-sample-preparation-products/spe-cartridges

- packed in flow-through fixed bed cartridges (E-PAK)
https://www.silicycle.com/products/e-pak-purification-cartridges

FAQ How to calculate the right amount of scavenger to remove metal / organic impurities

Oncotarget published this trending research perspective in Volume 12, Issue 25, entitled, "Cell fusion as a link between the SARS-CoV-2 spike protein, COVID-19 complications, and vaccine side effects" by Yuri Lazebnik, PhD., from Lerna Consulting, New Haven, CT.

Abstract:
A distinctive feature of the SARS-CoV-2 spike protein is its ability to efficiently fuse cells, thus producing syncytia found in COVID-19 patients. This commentary proposes how this ability enables spike to cause COVID-19 complications as well as side effects of COVID-19 vaccines, and suggests how these effects can be prevented.

Press release - https://www.oncotarget.com/news/pr/sars-cov-2-covid-19-vaccine-side-effects/

Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28088

DOI - https://doi.org/10.18632/oncotarget.28088

Full text - https://www.oncotarget.com/article/28088/text/

Correspondence to - Yuri Lazebnik - yuri@lernaconsulting.com

Keywords - cell fusion, thrombosis, neuropathy, cancer, vaccines

About Oncotarget

Oncotarget is a bi-weekly, peer-reviewed, open access biomedical journal covering research on all aspects of oncology.

To learn more about Oncotarget, please visit https://www.oncotarget.com or connect with:

SoundCloud - https://soundcloud.com/oncotarget
Facebook - https://www.facebook.com/Oncotarget/
Twitter - https://twitter.com/oncotarget
Instagram - https://www.instagram.com/oncotargetjrnl/
YouTube - https://www.youtube.com/c/OncotargetYouTube/
LinkedIn - https://www.linkedin.com/company/oncotarget
Pinterest - https://www.pinterest.com/oncotarget/
Reddit - https://www.reddit.com/user/Oncotarget/

Oncotarget is published by Impact Journals, LLC please visit https://www.ImpactJournals.com or connect with @ImpactJrnls

Media Contact
MEDIA@IMPACTJOURNALS.COM
18009220957

Trending With Impact: Negative Effects of the Spike Protein in SARS-CoV-2 and Some Vaccines

SCP SCIENCE CHANNEL

Микроволновая система разложения проб MiniWAVE - это компактная система с вертикальной загрузкой автоклавов, состоящая из сенсорного контроллера с возможностью подключения до 4-х микроволновых модулей. Каждый модуль вмещает до 6-ти образцов в тефлоновых или кварцевых сосудах объемом 75 мл. Используя два или более модулей, можно одновременно разложить совершенно разные типы образцов, используя индивидуальные методы для каждого.

ИК-датчик отслеживает температуру в каждом автоклаве. Магнетрон мощностью 1000 Вт расположен в нижней части камеры модуля. Благодаря конструкции системы, микроволновое излучение равномерно распределяется между автоклавами,  обеспечивая воспроизводимые результаты от пробы к пробе.  Идеальное решение для разложения экологических, геологических, проб, пищевых и сельскохозяйственных продуктов, различных продуктов нефтехимической и химической отраслей, биологических объектов и др.

Доступны системы 110V и 220V. 2.45 ГГц, 1000 Вт. Максимальная контролируемая температура 200 °C.

Микроволновая система разложения проб MiniWAVE

Thermo Fisher Scientific, Elemental and Structural Analysis

The ARL iSpark is a high performance OES spectrometer platform based on the best PMT (photomultiplier tube) optics. It features a revolutionary digital spark generator, and advanced signal acquisition and processing algorithms, for the most advanced OES analysis from trace elements to percent.

Find out more about the ARL iSpark OES metals analyzer at thermofisher.com/ispark

ARL iSpark Metals Analyzer. The Trusted Standard

The ARL easySpark excels in every aspect of the foundries, metal processors and other metallurgical industries and laboratories process, providing high speed elemental analysis of most metals and alloys with industry-leading performance, simple operation and maintenance, and low operating costs.

Find out more about the ARL easySpark OES metals analyzer at thermofisher.com/easyspark

ARL easySpark Bench-top Metals Analyzer

Agilent - LC

Introducing Agilent Feed Injection. Watch this video to learn how this novel LC injection technique can help you minimize the negative effects of strong sample solvent, support rapid gradients, and provide great injection precision for sub-1 µL injections.

Chemistry

Refine By

Keep up to date with all your favourite videos and channels.

Get personalised notifications on new releases and channel content by subscribing to the LabTube eNewsletter.