Cell Science

Custom Videos from Technology Networks

Watch this video from Sartorius to learn more about how to how to set up your plates and seed cells for live-cell assays.

How to Set Up Your Plates and Seed Cells for Live-Cell Assays

Aging

Aging published this high-scoring research paper on June 26, 2020, entitled, “Cognitive enhancement of healthy older adults using hyperbaric oxygen: a randomized controlled trial,” by researchers from the Shamir Medical Center, Zerifin, Israel; Tel-Aviv University, Tel-Aviv, Israel; Bar Ilan University, Ramat-Gan, Israel.

Abstract:
More than half of community-dwelling individuals sixty years and older express concern about declining cognitive abilities. The current study’s aim was to evaluate hyperbaric oxygen therapy (HBOT) effect on cognitive functions in healthy aging adults.

A randomized controlled clinical trial randomized 63 healthy adults (>64) either to HBOT(n=33) or control arms(n=30) for three months. Primary endpoint included the general cognitive function measured post intervention/control. Cerebral blood flow (CBF) was evaluated by perfusion magnetic resonance imaging.

There was a significant group-by-time interaction in global cognitive function post-HBOT compared to control (p=0.0017). The most striking improvements were in attention (net effect size=0.745) and information processing speed (net effect size=0.788).

Voxel-based analysis showed significant cerebral blood flow increases in the HBOT group compared to the control group in the right superior medial frontal gyrus (BA10), right and left supplementary motor area (BA6), right middle frontal gyrus (BA6), left middle frontal gyrus (BA9), left superior frontal gyrus (BA8) and the right superior parietal gyrus (BA7).

In this study, HBOT was shown to induce cognitive enhancements in healthy aging adults via mechanisms involving regional changes in CBF. The main improvements include attention, information processing speed and executive functions, which normally decline with aging.

To date, this study has generated an Altmetric Attention Score of 111. The Altmetric Attention Score provides an at-a-glance indication of the volume and type of online attention the research has received. 

Top Aging publications rated by Altmetric Attention Score -  https://www.aging-us.com/news_room/altmetric

Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.103571

DOI - https://doi.org/10.18632/aging.103571

Full text - https://www.aging-us.com/article/103571/text

Correspondence to: Amir Hadanny email: amir.had@gmail.com and Shai Efrati email: efratishai@outlook.com

Keywords: cognitive, hyperbaric oxygen, perfusion, cerebral blood flow, aging

About Aging

Launched in 2009, Aging publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways.

Please visit our website at http://www.Aging-US.com​​ or connect with us on:

Twitter - https://twitter.com/AgingJrnl​
Facebook - https://www.facebook.com/AgingUS/​
SoundCloud - https://soundcloud.com/aging-us​
YouTube - https://www.youtube.com/agingus​
LinkedIn -  https://www.linkedin.com/company/aging​

Aging is published by Impact Journals, LLC please visit http://www.ImpactJournals.com​​ or connect with @ImpactJrnls

Media Contact
18009220957
MEDIA@IMPACTJOURNALS.COM

Top-Performer: Hyperbaric Oxygen Yields Cognitive Benefits in Healthy Older Adults

Oncotarget

Oncotarget published this trending research paper on February 2, 2021, entitled, "Testosterone deficiency in men receiving immunotherapy for malignant melanoma" by researchers from the University of Iowa.

Abstract:
Immunotherapy has been established as a standard of care for patients with malignant melanoma, however, the long-term side-effects of immunotherapy are still emerging. Studies over the last decade have documented increasing reports of endocrine dysfunction following the initiation of immunotherapy. Our study aimed to detect the proportion of men who have low testosterone before, during, and or/after receiving immunotherapy for malignant melanoma, and to determine the proportion of men who receive testosterone replacement therapy after detection of low testosterone. We performed retrospective chart review of patients with malignant melanoma treated with immunotherapy. Low testosterone was identified in 34 out of 49 patients at some point during their treatment with immunotherapy. Despite low testosterone levels in two-thirds of patients, only three patients were treated with testosterone replacement therapy. In addition to laboratory evidence of low testosterone, patients were also symptomatic as 43 out of 49 patients reported fatigue to their providers. Four patients developed hypophysitis and subsequent hypopituitarism, all of whom were receiving Ipilimumab. We conclude that patients with stage 3 or 4 melanoma treated with immunotherapy appear to be at an increased risk of developing testosterone deficiency during their treatment.

Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.27876

DOI - https://doi.org/10.18632/oncotarget.27876

Full text - https://www.oncotarget.com/article/27876/text/

Correspondence to - Madeline Peters - madeline-peters@uiowa.edu

Keywords - cancer, melanoma, immunotherapy, testosterone deficiency, androgens, skin cancer

About Oncotarget

Oncotarget is a bi-weekly, peer-reviewed, open access biomedical journal covering research on all aspects of oncology.

To learn more about Oncotarget, please visit https://www.oncotarget.com or connect with:

SoundCloud - https://soundcloud.com/oncotarget
Facebook - https://www.facebook.com/Oncotarget/
Twitter - https://twitter.com/oncotarget
YouTube - https://www.youtube.com/c/OncotargetYouTube/
LinkedIn - https://www.linkedin.com/company/oncotarget
Pinterest - https://www.pinterest.com/oncotarget/
Reddit - https://www.reddit.com/user/Oncotarget/

Oncotarget is published by Impact Journals, LLC please visit https://www.ImpactJournals.com or connect with @ImpactJrnls

Media Contact
MEDIA@IMPACTJOURNALS.COM
18009220957

Trending with Impact: Melanoma, Immunotherapy, and Testosterone Deficiency

Webinars by Technology Networks 

Webinar Summary
T cells mediate the classic immune response to viral infections and appear to play these roles in fighting COVID-19 and clearing SARS-CoV-2. In addition to killing virally infected cells, T cells direct the production of high-affinity and neutralizing antibodies. In other viral illnesses, T-cell immunity provides long-term, durable protection and blocks forward transmission; protective immunity decreases the symptom severity of subsequent infection.

The goal of vaccination is to mimic the protective immunity from natural infection with lower risk. The mRNA Emergency Use Authorization (EUA) vaccines have shown high levels of protection against symptomatic COVID-19 for at least six months. The SARS-CoV-2 variants are concerning, and appear to evade antibody immunity, but perhaps not T-cell immunity. The prospect that T cell-directed vaccines may protect against variants has scientists racing to develop broadly protective vaccines ahead of the rapidly evolving mutants.

Attendees will learn how:

T cells (helper and killer) work in tandem to control and clear the ongoing infection
T cells recognize and eliminate SARS-CoV-2 infected cells
Vaccines can elicit T-cell immune responses

T-Cell Immunity and COVID-19

Watch this video to learn more about the custom and bulk antibody services offered by Bethyl Labs/Fortis Life Sciences.

Custom and Bulk Antibody Services

Teach Me in 10

Air-liquid Interface (ALI) is ideal for studying respiratory tract epithelial cells because it exposes one side of the culture to liquid media and surrounds the other with air. ALI systems therefore allow researchers to more accurately mimic in vivo conditions compared to using conventional cell culture models. This makes them ideal to perform mechanistic studies of respiratory epithelial cells as drug permeation barriers, to model respiratory diseases like cystic fibrosis and asthma, to investigate essential dermal processes such as wound healing and to advance understanding of respiratory epithelium infections, including SARS-CoV-2.  From asthma to COPD, ALI models have been critical in researching respiratory diseases. With the recent outbreak and severity of the COVID-19 virus, this technology is becoming even more critical in the race to understand and treat disease. With the popularity of these more complex models growing, join this Teach Me in 10 session to hear Corning Life Sciences Digital Manager Roxana Ghadessy and Corning Life Sciences Product Line Manager Shabana Islam talk to us about disease modeling using ALI tools and systems.

For more information on ALI tools, be sure to check out the following resources:  
https://www.corning.com/catalog/cls/documents/application-notes/CLS-AN-527.pdf 

https://www.corning.com/catalog/cls/documents/application-notes/CLS-AN-493.pdf 

https://www.corning.com/catalog/cls/documents/application-notes/CLS-AN-599.pdf 

https://www.corning.com/catalog/cls/documents/citations-references/CLS-AN-605.pdf 

https://www.corning.com/worldwide/en/products/life-sciences/resources/stories/the-cutting-edge/tissue-engineering-the-latest-3d-cellular-models-for-respiratory-drug-development.html 

https://www.corning.com/worldwide/en/products/life-sciences/resources/stories/in-the-field/using-air-liquid-interface-in-your-research.html 

https://www.biocompare.com/Bench-Tips/564894-Uses-and-Best-Practices-for-Air-Liquid-Interface-Systems/#:~:text=Air%2Dliquid%20interface%20(ALI),of%20multi%2Dlayered%20skin%20models

https://www.corning.com/worldwide/en/products/life-sciences/applications/disease-modeling/air-liquid-interface.html

Disease Modeling Using ALI Tools and Systems

CD Genomics

CD Genomics is offering five platforms for genome-wide epigenomics analysis, each designed to accommodate a wide range of sample types and suit your specific research needs, allowing researchers to look at epigenetic alterations easily. This information will help us not only understand the role of DNA methylation but also identify targets for therapeutic treatment. https://www.cd-genomics.com/Epigenomics.html

Epigenetic Modifications and Epigenomic Technologies

As a leading provider of NGS services, CD Genomics is providing an integrated portfolio of methylation sequencing services. Whole genome bisulfite sequencing (WGBS) is an effective and reliable strategy to identify individually methylated cytosines on a genome-wide scale. With over 10 years of experience and the state-of-the-art next-generation sequencing platforms, we can totally meet your project requirements and budgets in the exploration of methylome. 


https://www.cd-genomics.com/Whole-Genome-Bisulfite-Sequencing.html

Principle and Workflow of Whole Genome Bisulfite Sequencing

Creative Proteomics videos

iTRAQ (Isobaric tag for relative and absolute quantitation) was developed by Applied Biosystems Incorporation in 2004. iTRAQ is a isobaric labeling method to determine the amount of proteins from different sources in just one single experiment. The iTRAQ reagents available always are set of 4-plex and 8-plex mass tages that can be used to label and et quantitative information on up to 4 and 8 different samples in one experiment
https://www.creative-proteomics.com/services/itraq-based-proteomics-analysis.htm

Cell Science

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