Cell Culture

CD Genomics

What is 16S rRNA gene?
What is 16S rRNA sequencing?
Workflow of 16S rRNA sequencing
https://www.cd-genomics.com/16S-18S-ITS-Amplicon-Sequencing.html

The Workflow of 16S rRNA Sequencing

Sekisui XenoTech

Presenter: Zell Woodworth, Division Director of Products at SEKISUI XenoTech 

Abstract: 
Sometimes, standard products just don’t fit the objective of a unique assay. In this webinar, Products Director and custom test system expert, Zell Woodworth, will discuss some of the unique challenges his team have solved and the ways custom solutions are designed and executed to help researchers and drug developers meet goals outside the reach of standard in vitro products. He will be joined by Manager of Technical Support for Products, Dr. Chris Bohl, for a live Q&A with webinar registrants. 

The dedicated Custom Products team at SEKISUI XenoTech has impressive experience and specialized training in preparing test systems from notoriously difficult to work with tissue types. They have built an impressive collection of custom protocols for more than 40 different animal species (including insects!) and can design custom pools for improved representation of specific enzyme activity or patient characteristics. Tune in to hear about some of the custom solutions they have created to address challenges by researchers in drug metabolism, toxicology, cell biology, pathogen-host interactions, metabolomics, and more, as well as some background information on the team’s capabilities and technologies, the process of creating custom products, and several examples of applications for specialized in vitro test systems. 

Key concepts discussed in this webinar will include:
 - Past challenges addressed by SEKISUI XenoTech custom test systems
 - Species, tissue types, subcellular fractions, pooling, and other capabilities
 - Flexibility of existing or specially-created protocols for preparations
 - Areas of drug development and research our custom products may benefit 

Request a copy of the slides: https://www.xenotech.com/about/events/webinar-addressing-unique-challenges-with-custom-in-vitro-test-systems/
Questions, comments and requests: https://www.xenotech.com/contact/
More information on our research services and test systems: https://www.xenotech.com
Other previously aired webinars: https://www.xenotech.com/access-adme-research-resources/resource-type/webinar/
Upcoming webinar notifications: https://www.xenotech.com/contact/newsletter-sign-up/
Request a webinar topic: https://www.xenotech.com/contact/webinar-seminar-request/

About the Presenters: 
Zell Woodworth serves as the Division Director of Products at SEKISUI XenoTech. Zell holds a Bachelor of Science in Biology and Chemistry from Olivet Nazarene University in Illinois. He began his career with XenoTech in 1996 and has over 25 years of experience in the development, production, and distribution of tissue-derived in vitro experimental models essential in drug candidate screening, drug-drug interaction investigations, and drug safety. Zell manages raw material procurement, development, production, and quality control of over 350 biological products utilized in pharmaceutical research in over 25 countries. He continues to provide technical support, product workshops, and in vitro test system support to researchers throughout the world. 

Dr. Chris Bohl received his PhD from the School of Biological Sciences from the University of Nebraska – Lincoln and has been with SEKISUI XenoTech since 2014, first operating as a research scientist before becoming the Senior Manager of Technical Support for Products. Chris provides valuable guidance to scientists seeking to choose the correct test system, troubleshoot difficulties and much more.

Addressing Unique Challenges with Custom In Vitro Test Systems

Wyss Institute for Biologically Inspired Engineering at Harvard University

Using Human Organ Chips, researchers at the Wyss Institute were able to generate the mucus layer of the colon in vitro, which has never been done before. In the colon, the mucus layer protects intestinal epithelial cells against inflammatory stimuli such as pathogens, damaged cells, or irritants. The ability to support mucus-producing cells is one step towards modeling inflammatory bowel diseases in vitro.
 
For more information, please visit: https://wyss.harvard.edu/news/investigating-the-human-intestinal-mucus-barrier-up-close-and-personal/
 
Credit: Wyss Institute at Harvard University

Mucus Layer In Vitro on Human Colon Chip

Lucid Scientific

A fun whiteboard video outlining the features and benefits of the Resipher OCR device.

Learn more about the Lucid Scientific Resipher OCR Device

Presenters: Andrew G. Taylor, Ph.D., Manager of Technical Support for Services at SEKISUI XenoTech and Scott Boley, Ph.D., DABT, Senior Vice President of Research at Sinclair Research

Abstract:
Choosing the most relevant species for your toxicity studies is critical to ensure your IND provides the relevant data regulators need to advance your program to clinical trials. But selecting the right species for your nonclinical program must be based on scientific rationale and begins with understanding the potential species-dependent variability in the metabolism of your drug.  The decision of which animal model to utilize may not always be obvious. Comparing animal species to human data helps identify human or animal-specific metabolites and can help you identify the most appropriate species to generate the nonclinical safety data needed to progress your program into Phase 1.

This  webinar will dive into the scientific rationale driving species selection for your nonclinical program with an emphasis on how in vitro species comparison studies can help to determine the right species for your in vivo program.

Key concepts discussed in this webinar will include:
 - Drivers of species selection for nonclinical programs
 - Considerations for rodent and non-rodent species selection
 - Characteristics and structural assignment of metabolites in different preclinical species
 - In vitro species comparison screening studies

Download a copy of the slides: https://www.xenotech.com/wp-content/uploads/2021/07/Selecting-The-Right-Species-For-My-Small-Molecule-Program-The-Role-Of-In-Vitro-Assays.pdf
Questions, comments and requests: https://www.xenotech.com/contact/
More information on our research services and test systems: https://www.xenotech.com
Other previously aired webinars: https://www.xenotech.com/access-adme-research-resources/resource-type/webinar/
Upcoming webinar notifications: https://www.xenotech.com/contact/newsletter-sign-up/
Request a webinar topic: https://www.xenotech.com/contact/webinar-seminar-request/

About the Presenters:
Andrew G. Taylor, PhD, received his PhD from University of California San Diego. He joined SEKISUI XenoTech as a research scientist in 2017, serving as a Study Director in nonclinical drug interaction contract studies in compliance with Good Laboratory Practices (GLP), OECD Principles of GLP, &/or Japan MOHW GLP Standards and specializing in drug transport and drug metabolism studies. He became the Technical Support Manager for services in 2020 and provides valuable guidance to ensure research needs are being met.

Scott E. Boley, PhD, DABT, has advised sponsors on their nonclinical needs for the last 15 years and managed toxicology programs for over 19 years. He has extensive expertise in drug development as well as the regulatory expectations for a variety of test article types and indications. In his role as Senior Vice President of Research, Scott oversees the Research, Report Services, and SEND groups at Sinclair Research that supports each Sponsor’s nonclinical safety programs. Scott is a diplomate of the American Board of Toxicology and holds a B.Sc. in Biochemistry and a Ph.D. in Biochemistry/Environmental Toxicology from Michigan State University.

Webinar: Selecting The Right Species For My Small Molecule Program-The Role Of In Vitro Assays

Learn more about SNP Genotyping Technologies at CD Genomics: https://www.cd-genomics.com/

SNP Genotyping Technologies

BioTek Instruments

BioTek Synergy Neo2 hybrid multimode reader is designed for the screening laboratory, with speed and ultra-high performance. Variable bandwidth quad monochromators, sensitive high transmission filter-based optics, laser TRF and up to 4 PMTs provide ultra-fast measurements with excellent results. For walk-away automation and high throughput, BioStack Neo microplate stacker is the fastest on the market, and the barcode-labeled filter cubes help streamline workflows and limit errors. Synergy Neo2 features BioTek’s patented Hybrid Technology, with its independent optical paths that ensure uncompromised performance in all detection modes. Advanced environmental controls, including CO2/O2 control, incubation to 70°C and variable shaking support live cell assays; cell-based detection is optimized with direct bottom illumination. Powerful Gen5 Software offers complete reader control, powerful data analysis, and automation and LIMS integration.

Learn more about the Synergy Neo2 visit: http://www.biotek.com/neo2 

Helpful links: 
Agilent BioTek Gen5 data analysis software https://www.biotek.com/products/software-robotics-software/gen5-microplate-reader-and-imager-software/
Agilent BioTek BioStack Neo https://www.biotek.com/products/software-robotics-robotics/biostack-microplate-stacker/

Agilent BioTek Synergy Neo2 Hybrid Multimode Microplate Reader

Custom Videos from Technology Networks

Watch this video from Sartorius to learn more about how to how to set up your plates and seed cells for live-cell assays.

How to Set Up Your Plates and Seed Cells for Live-Cell Assays

Creative Proteomics videos

iTRAQ (Isobaric tag for relative and absolute quantitation) was developed by Applied Biosystems Incorporation in 2004. iTRAQ is a isobaric labeling method to determine the amount of proteins from different sources in just one single experiment. The iTRAQ reagents available always are set of 4-plex and 8-plex mass tages that can be used to label and et quantitative information on up to 4 and 8 different samples in one experiment
https://www.creative-proteomics.com/services/itraq-based-proteomics-analysis.htm

Cell Culture

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