Cancer Research

Radleys

In this video we demonstrate how to maintain your Heidolph rotary evaporator. We will show you how to disassemble the glassware and clean it, how to inspect and clean the vacuum seal and finally how to reassemble the glassware ready for evaporation and efficient distillations.

Regular maintenance of your rotary evaporator will ensure that it stays in top working condition and gives the best vacuum tightness for efficient distillations. Keeping your rotary evaporator well maintained will also reduce the risk of cross contamination of different samples when evaporating different batches of products.

The Hei-VAP series of rotary evaporators from Heidolph are ideal for evaporating, distilling and extracting solvents. The Hei-VAP benchtop rotary evaporators are used around the world for chemical research, organic chemistry, medicinal chemistry, process development, solvent recovery, solvent recycling, CBD extractions, product drying etc. 

The Hei-VAP rotary evaporators feature:
• Industry leading safety features
• Easy to remove glass vapour tube, clamping sleeve and graphite filled PTFE seal, engineered to reduce wear and consumption of spares by up to 75%
• Patented Easy-Clip flask clamp enables removal of flasks from the drive, without jamming
• 3 year warranty standard on all Hei-VAP models
• Novel detachable operating panel, which allows precise control of all important parameters outside the fume hood. 
• Upgraded design of heating bath has IP67 rating, heats to an unmatched 210°C, accepts large flasks up to 5 litres and features a convenient pouring spout for spill free emptying
• Optional plastic coated glass sets to protect you from implosions
• Unbeatable lowest cost of ownership throughout the life of the Hei-VAP Rotary Evaporator
• Rotation speed and heating bath temperature are controlled by two separate operating knobs which are illuminated by LED ring lights
• Both controls can be locked to prevent accidental changing of the values, perfect for teaching labs
• Heating knob lights up orange to indicate when heating is active and when in standby mode, blinks when the bath is over 50 ˚C to prevent burns
• Display panel is made of glass-bead strengthened material that is splash water resistant in accordance with IP 42
• Heating bath has new ergonomic handles and pour spout to make emptying safe and simple. It also has an IP 67 rated power cable to protect against short circuits and corrosion

Find out more at https://www.radleys.com/range/hei-vap-rotary-evaporators/
To book a demo, visit: https://calendly.com/heidolph-instruments

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How to maintain your rotary evaporator for distillations and solvent extractions

Biotech Videos 

Monoclonal antibodies are produced by identical immune cells that are clones of a specific parent cell. Monoclonal antibodies can only recognize the same antigen and epitope. Polyclonal antibodies are produced by different immune cells that have affinity for different epitopes of the same antigen. Therefore, monoclonal antibodies are much more specific and with less background noise than polyclonal antibodies. However, monoclonal antibodies are also usually more expensive to produce, less robust and are very sensitive to small changes in the antigen compared with polyclonal antibodies.https://www.antibody-creativebiolabs.com/

Antibody based Cancer Therapies

Prostate cancer (PCa) is the second leading cause of cancer death in American men, behind lung cancer and it predominately affects elderly men with higher incidence. About 1 man in 41 will die of prostate cancer. The development of PCa involves several mutations in prostate epithelial cells, usually linked to developmental changes, such as enhanced resistance to apoptotic death, constitutive proliferation, and, in some cases, to differentiation into an androgen deprivation-resistant phenotype, leading to the appearance of castration-resistant PCa (CRPCa), which leads to a poor prognosis in patients.https://www.antibody-creativebiolabs.com/prostate-cancer-overview-signaling-pathway.htm

Prostate Cancer Overview

Pancreatic cancer is one of the malignant tumors with strong invasiveness, high degree of deterioration and low surgical resection rate in the digestive system, ranking third in cancer-related deaths in the United States. The 5-year survival rate of patients is <5%, and the median survival time is only 5-6 months. https://www.antibody-creativebiolabs.com/pancreatic-cancer-overview-signaling-pathway.htm

Pancreatic Cancer Overview

breast, lung, and colorectal cancers. Risk factors are related to excessive unopposed exposure of the endometrium to estrogen, including unopposed estrogen therapy, early menarche, late menopause, tamoxifen therapy, nulliparity, infertility or failure to ovulate, and polycystic ovary syndrome. Additional risk factors are increasing age, obesity, hypertension, diabetes mellitus, and hereditary nonpolyposis colorectal cancer. The American Cancer Society recommends that all women older than 65 years be informed of the risks and symptoms of endometrial cancer and advised to seek evaluation if symptoms occur.https://www.antibody-creativebiolabs.com/endometrial-cancer-overview-signaling-pathway.htm

Endometrial Cancer Overview

Thyroid cancer (TC) remains the most common endocrine malignancy worldwide and its incidence and mortality has increased steadily over the last four decades.https://www.antibody-creativebiolabs.com/thyroid-cancer-overview-signaling-pathway.htm

Thyroid Cancer Overview

Handheld Raman Spectrometer

Finder edge as a handheld Raman analyzer has drastically changed the way the pharmaceutical industry quality control for incoming raw materials, the intuitive onboard software make it easy to operate. Zolix is dedicated to providing the best handheld Raman solutions possible. Finder edge is instant, portable and flexible. It has two ways to test samples. One is vial holder, it help to test the powder or liquid samples in vials. The other is point and shoot adapter, when you utilize it to test, just contact the samples. The professional software provide multilevel access control and straightforward user management. You can easily identify the kind of sample by QR code scanning, and judge whether it is passed or not by pressing the screen icon or the push-button. When you finish testing, just press one button to generate the report with audit trails and electronic signature. It fully compliant with FDA 21 CFR part 11. 
Finder edge handheld Raman spectrometer will be your high quality and reliable partner.

Handheld Raman Analyzer

Teach Me in 10

In this installment of Teach Me in 10, we're joined by Matt Cooper, co-founder and chief scientific officer at Wugen, Inc. He is also assistant professor of medicine at Washington University. Matt discusses what T cells are and how they can be engineered to recognize cancer cells. This can be achieved by incorporating a specific receptor – the chimeric antigen receptor (CAR) – which results in the generation of CAR T cells. “CAR T cells are essentially a living targeted drug,” says Matt. Learn more about the key challenges related to engineering CAR T cells, discover ways to enable the broader application of these cells and hear about the development of allogeneic CAR T cells as an “off-the-shelf” treatment for cancer. You can learn more about CAR T cells by checking out the following content: [url][link]https://www.technologynetworks.com/cancer-research/lists/treating-cancer-5-types-of-immunotherapy-327728[/link][name]Treating Cancer – 5 Types of Immunotherapy[/name][/url], [url][link]https://www.technologynetworks.com/cancer-research/podcasts/opinionated-science-episode-14-cancer-immunotherapy-vaccines-viruses-and-nobel-prizes-340857[/link][name]Opinionated Science Episode 14: Cancer Immunotherapy: Vaccines, Viruses and Nobel Prizes[/name][/url] and [url][link]https://www.technologynetworks.com/cancer-research/infographics/cancer-and-the-immune-system-331284[/link][name]Cancer and the Immune System[/name][/url].

CAR T Cells: A Living Targeted Drug, With Dr Matt Cooper

Creative Biolabs

T-cell redirecting therapies with gene-engineered CAR T-cells and T-cell engaging bispecific antibodies (bsAb) are showing promising results in clinical trials. To guide precision immunotherapy, other factors should also be taken into consideration, including greater availability of immune targets and compounds with different modes of action during the development of new biomarkers, and determinants of response and resistance to a specific regimen.
https://www.creative-biolabs.com/bsab/new-ways-of-evaluating-the-tumor-immune-microenvironment-from-bench-to-bedside.htm

Cancer Research

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