Cancer Research

Wyss Institute for Biologically Inspired Engineering at Harvard University

Responding to an unmet need for a robotic surgical device that is flexible enough to access hard to reach areas of the G.I. tract while causing minimal peripheral tissue damage, Researchers at the Wyss Institute and Harvard SEAS have developed a laser steering device that has the potential to improve surgical outcomes for patients. 

For more information, please visit: https://wyss.harvard.edu/news/wielding-a-laser-beam-deep-inside-the-body

Credit: Wyss Institute at Harvard University

A Laser Steering Device for Robot-assisted Surgery

Don Whitley Scientific

This video demonstrates some of the benefits of using a Whitley Hypoxystation instead of a traditional incubator

Control your culture atmosphere with precision - using a Whitley Hypoxystation

Thermo Fisher Scientific, Molecular Biology

Invitrogen E-Gel Precast Agarose Gels enable fast and sensitive analysis of DNA and RNA samples. Minimize time-consuming and messy prep work, running up to twice as fast as conventional handcast gels. E-Gel Precast Agarose Gels are available in a variety of agarose percentages, well formats, and throughput capacities to suit your applications.

Save Time with Invitrogen E-Gel Precast Agarose Gels

Sekisui XenoTech

Presented by SEKISUI XenoTech Technical Support Managers, Drs. Andrew G. Taylor and Chris Bohl Metabolic stability influences the oral bioavailability and plasma half-life of a compound. Metabolic stability assays measure intrinsic clearance and determine the extent to which a drug will be metabolized. This study can be conducted in a variety of test systems, which is why it may also be referred to as a hepatocyte stability study, microsomal stability study, etc. This quick overview video discusses: - Test systems for stability assays - Stability study endpoints - Example data in different species - Considerations for those wanting to conduct stability studies Download slides: https://www.xenotech.com/wp-content/uploads/2020/11/SEKISUI-XenoTech_Metabolic-Stability-ADME-101.pdf Questions, comments and requests: https://www.xenotech.com/contact/ More information on our research services and test systems: https://www.xenotech.com Other previously aired webinars: https://www.xenotech.com/access-adme-research-resources/resource-type/webinar/ Upcoming webinar notifications: https://www.xenotech.com/contact/newsletter-sign-up/ Request a webinar topic: https://www.xenotech.com/contact/webinar-seminar-request/ About the Presenters: Dr. Andrew G. Taylor received his Ph.D. from University of California San Diego. He joined SEKISUI XenoTech as a research scientist in 2017, serving as a Study Director in nonclinical drug interaction contract studies in compliance with Good Laboratory Practices (GLP), OECD Principles of GLP, &/or Japan MOHW GLP Standards and specializing in drug transport and drug metabolism studies. He became the Technical Support Manager for services in 2020 and provides valuable guidance to ensure research needs are being met. Dr. Chris Bohl received his PhD from the School of Biological Sciences from the University of Nebraska – Lincoln and has been with SEKISUI XenoTech since 2014, first operating as a research scientist before becoming the Senior Manager of Technical Support for Products. Chris provides valuable guidance to scientists seeking to choose the correct test system, troubleshoot difficulties and much more.

ADME 101: Drug Metabolism Studies – Metabolic Stability

CEM_Corporation

The Discover® 2.0 is the best microwave synthesizer for organic and inorganic synthetic chemistry. Featuring the widest range of pressurized vessels for a single-mode microwave cavity and intuitive software with a 10" touchscreen interface. The Discover 2.0 also comes with a complete range of accessories including autosamplers, subambient chemistry, gaseous addition, and peptides synthesis. Features: -Widest pressurized vessel sizes for a single-mode microwave - 10mL, 35mL, 100mL -IR Temperature Sensor that sees through glass and Teflon® (iWave®) -Vent and reseal technology for safe handling of over-pressurization (ActiVent) -Variable speed magnetic stirring and rapid compressed air cooling -Upgrade options: Autosamplers - 12/48 positions; Gaseous Addition, Sub-ambient temperature, Flow cells Want more CEM updates and videos? Subscribe to our channel: https://www.youtube.com/c/CEMCorporation Check out CEM's Resource Library to download various Application Notes: http://cem.com/literature?literature_... Explore CEM's Microwave Synthesis page: https://cem.com/en/microwave-synthesis Connect with us Follow @CEMcorporation on Twitter: https://twitter.com/CEMcorporation Follow and Like on Facebook: https://www.facebook.com/CEMCorporation Follow CEM on LinkedIn: https://www.linkedin.com/company/cem-... Subscribe to CEM on YouTube: https://www.youtube.com/c/CEMCorporation Follow CEM on Instagram: https://www.instagram.com/cemcorporation/

Microwave Synthesis Reactor | Discover 2.0 | CEM

Bruker Mass Spectrometry

In this interview, Chris discusses the proteomics process and advantages of timsTOF Pro technology. They also discuss the collaboration between Bruker and the Yates lab which made real-time search a reality on the timsTOF Pro, and the advantages of real-time search.

Interview with Bruker's Chris Adams, Global Business Product Manager for Integrated Proteomics

Presenter: Pallavi Limaye, Ph.D., DABT, SEKISUI XenoTech Director of Scientific Consulting This informative ADME 101 discusses In Vitro to In Vivo Extrapolation (IVIVE) and how a model-based approach following routine perpetrator potential studies (i.e. CYP inhibition, CYP induction, and transporter inhibition) assessing clinical potential may eliminate the need of conducting clinical studies. Listen in as Dr. Limaye outlines a step–wise approach for bringing robustness to the prediction, including: - Regulatory guidance - ADME & DDI study types for in vitro to in vivo prediction - Models for DDI prediction - Decision tree for whether modeling is needed - Model equations by study type Download slides: https://www.xenotech.com/wp-content/uploads/2020/10/SEKISUI-XenoTech_DDI-Modeling-ADME-101.pdf Questions, comments and requests: https://www.xenotech.com/contact/ More information on our research services and test systems: https://www.xenotech.com Other previously aired webinars: https://www.xenotech.com/access-adme-research-resources/resource-type/webinar/ Upcoming webinar notifications: https://www.xenotech.com/contact/newsletter-sign-up/ Request a webinar topic: https://www.xenotech.com/contact/webinar-seminar-request/ About the presenter: Dr. Pallavi Limaye is a Director in the Scientific Consulting department. Pallavi completed her Ph.D. in Toxicology from The University of Louisiana and her postdoctoral research in the Department of Pathology at University of Pittsburgh Michalopoulos and subsequently at the Department of Pharmacology, Toxicology, and Therapeutics at University of Kansas Medical Center. Dr. Limaye originally joined SEKISUI XenoTech in 2011 as a Research Scientist and served as a study director for in vitro drug metabolism studies. In 2013, she joined Xenometrics LLC, as a Senior Scientist and served as a study director for regulated nonclinical IND- and NDA-enabling toxicology studies. From 2018 to 2020 Dr. Limaye worked at MRIGlobal as a Principal Scientist and oversaw nonclinical toxicology and animal health studies, as well as contributed to containment research with select chemical agents. Recently Dr. Limaye joined SEKISUI XenoTech’s consulting team and provides input on drug-drug interaction study needs for sponsors. Dr. Limaye has published several original research articles in various journals (Hepatology, Toxicological Sciences among others) and has also contributed many book chapters in the field of toxicology and liver pathobiology. Dr. Limaye is also actively involved in scientific societies and currently serves on the Program Committee of The American College of Toxicology and is the Vice President of the Central States regional chapter of The Society of Toxicology.

Model-Based Approaches to DDI Risk Prediction-Transitioning from In Vitro Data to In Silico Modeling

Teach Me in 10

Now – more than ever before – it's critical that pharma QA/QC labs have solutions in place that enable them to deliver medicines faster and safely. How are digital solutions being used to enable pharma manufacturing, particularly in such labs? That is the topic of focus for this industry special of Teach Me in 10, where we're joined by Dr Stephen Moore, Services Manager, Digital Science, Thermo Fisher Scientific. With 16 years’ industrial experience in clinical diagnostics, genomics and informatics, including laboratory operation, bioinformatics, project management and scientific software implementations, Stephen has built a wealth of knowledge and expertise around LIMS project requirements. Here, he looks at the common challenges experienced by pharmaceutical QA/QC laboratories looking to implement laboratory software solutions, on their digital transformation journey. He discusses the latest digital technologies available to labs, and bring to you some expert advice and guidance for project planning and management to help you ensure successful, timely delivery of your laboratory software solution.

Teach Me in 10 – Enabling Pharma Manufacturing Through Digital Solutions With Dr Stephen Moore 

What’s one of the most important prerequisites for MALDI imaging?  LC-MS!  Find out how SpatialOMx® is providing context to OMICS and where the field is going next and why pathology researchers care in an interview with Michael L. Easterling, Manager of Bruker’s Imaging Business

Cancer Research

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