Bioprocessing

Aging (Aging-US)

Aging (Aging-US) published this trending research paper in Volume 13, Issue 24, entitled, "Maternal adverse childhood experiences before pregnancy are associated with epigenetic aging changes in their children" by researchers from the Gangarosa Department of Environmental Health, Emory Rollins School of Public Health, Atlanta, GA; Department of Emergency Medicine, Emory University School of Medicine, Atlanta, GA; Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA; Center for Computational Biology, School of Public Health, University of California, Berkeley, CA; Center for Environmental Research of Community Health, CERCH, School of Public Health, University of California, Berkeley, CA; Community Health Sciences Division, School of Public Health, University of California, Berkeley, CA.

Abstract:
Emerging research suggests associations of physical and psychosocial stressors with epigenetic aging. Although this work has included early-life exposures, data on maternal exposures and epigenetic aging of their children remain sparse. Using longitudinally collected data from the California, Salinas Valley CHAMACOS study, we examined relationships between maternal Adverse Childhood Experiences (ACEs) reported up to 18 years of life, prior to pregnancy, with eight measures (Horvath, Hannum, SkinBloodClock, Intrinsic, Extrinsic, PhenoAge, GrimAge, and DNAm telomere length) of blood leukocyte epigenetic age acceleration (EAA) in their children at ages 7, 9, and 14 years (N = 238 participants with 483 observations). After adjusting for maternal chronological age at delivery, pregnancy smoking/alcohol use, parity, child gestational age, and estimated leukocyte proportions, higher maternal ACEs were significantly associated with at least a 0.76-year increase in child Horvath and Intrinsic EAA. Higher maternal ACEs were also associated with a 0.04 kb greater DNAm estimate of telomere length of children. Overall, our data suggests that maternal preconception ACEs are associated with biological aging in their offspring in childhood and that preconception ACEs have differential relationships with EAA measures, suggesting different physiologic utilities of EEA measures. Studies are necessary to confirm these findings and to elucidate potential pathways to explain these relationships, which may include intergenerational epigenetic inheritance and persistent physical and social exposomes.

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DOI - https://doi.org/10.18632/aging.203776

Full text - https://www.aging-us.com/article/203776/text

Correspondence to: Andres Cardenas email: andres.cardenas@berkeley.edu

Keywords: ACES, epigenetic age, DNA methylation, mitotic clocks, adversity

About Aging-US

Launched in 2009, Aging-US publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging-US go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways.

Please visit our website at http://www.Aging-US.com​​ or connect with us on:

SoundCloud - https://soundcloud.com/Aging-Us
Facebook - https://www.facebook.com/AgingUS/
Twitter - https://twitter.com/AgingJrnl
Instagram - https://www.instagram.com/agingjrnl/
YouTube - https://www.youtube.com/agingus​
LinkedIn - https://www.linkedin.com/company/aging/
Pinterest - https://www.pinterest.com/AgingUS/

Aging-US is published by Impact Journals, LLC please visit http://www.ImpactJournals.com​​ or connect with @ImpactJrnls

Media Contact
18009220957
MEDIA@IMPACTJOURNALS.COM

Trending With Impact: Maternal ACEs Associated With Biological Aging in Children

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In 2017, the 2nd Interventions in Aging Conference on "Understanding Mechanisms & Compressing Morbidity in Aging Humans" was held in Cancun, Mexico. The co-chairs of this conference, and speakers in this Aging (Aging-US) video, are Drs. Dame Linda Partridge DBE, FRS, FRSE, FMedSci, and Brian Kennedy Ph.D. 

Dr. Partridge is currently the Weldon Professor of Biometry in the Department of Genetics, Evolution and Environment at the University College London (UCL), Director of UCL's Institute of Healthy Ageing, and the Founding Director of the Max Planck Institute for the Biology of Ageing. 

Dr. Kennedy is a Distinguished Professor in the Department of Biochemistry and Physiology at the National University of Singapore (NUS)'s Yong Loo Lin School of Medicine. Dr. Kennedy is also Director of the National University Health System (NUHS) Centre for Healthy Ageing in Singapore, Professor at the Buck Institute for Research on Ageing, Adjunct Professor at the University of Southern California's Leonard Davis School of Gerontology, and Affiliate Faculty in Department of Biochemistry at the University of Washington.

In this video, these two prominent researchers briefly discussed the state of aging research in 2017, and postulated what the future of aging interventions may look like.

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DOI - https://doi.org/10.18632/aging.101221

Full Text - https://www.aging-us.com/article/1012...

Correspondence to: Brian K. Kennedy email: bkennedy@buckinstitute.org and Linda Partridge email: partridge@age.mpg.de

Keywords: healthspan, organismal aging, epigenetics, longevity, cellular mechanisms, metabolism, aging, conference

About Aging (Aging-US)

Launched in 2009, Aging-US publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging-US go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways.

Please visit our website at http://www.Aging-US.com​​ or connect with us on:

SoundCloud - https://soundcloud.com/Aging-Us
Facebook - https://www.facebook.com/AgingUS/
Twitter - https://twitter.com/AgingJrnl
Instagram - https://www.instagram.com/agingjrnl/
YouTube - https://www.youtube.com/agingus​
LinkedIn - https://www.linkedin.com/company/aging/
Pinterest - https://www.pinterest.com/AgingUS/

Aging-US is published by Impact Journals, LLC please visit http://www.ImpactJournals.com​​ or connect with @ImpactJrnls

Media Contact
18009220957
MEDIA@IMPACTJOURNALS.COM

Author Insight: The State of Aging Research (2017): Drs. Linda Partridge & Brian Kennedy

Aging (Aging-US) published this trending research paper on October 13, 2020, entitled, "Effects of estradiol on biological age measured using the glycan age index" by researchers from Genos Glycoscience Research Laboratory, Zagreb, Croatia; Division of Geriatric Medicine, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO; Eastern Colorado VA Geriatric Research, Education and Clinical Center, Aurora, CO; Department of Biochemistry and Molecular Biology, Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women´s Hospital, Boston, MA; Division of Immunology, Boston Children´s Hospital, Boston, MA.

Abstract:
Glycan age is a recently developed biomarker based on glycans attached to immunoglobulin G (IgG). In large population cohorts, glycan age associates well with lifestyle and disease-risk biomarkers, while some studies suggested that glycan changes precede development of several age-associated diseases. In this study we evaluated effects of estrogen on the glycan age. Gonadal hormones were suppressed in 36 healthy young women by gonadotropin releasing hormone agonist therapy for 6 months. In 15 of them estradiol was supplemented, while 21 received placebo resulting in very low estrogen levels during intervention. IgG was isolated from plasma samples before intervention, after 6 months of intervention and after subsequent 4-month recovery. Deprivation of gonadal hormones resulted in median increase of glycan age for 9.1 years (IQR 6.8 – 11.5 years, p = 3.73×10-8), which was completely prevented by transdermal estradiol therapy (change in glycan age = -0.23 years, IQR (-2.20 – 2.98). After the recovery period glycan age returned to baseline values in both groups. These results suggest that IgG glycans and consequently also the glycan age are under strong influence of gonadal hormones and that estradiol therapy can prevent the increase of glycan age that occurs in the perimenopausal period.

Press release - https://www.aging-us.com/news_room/effects-of-estradiol-on-biological-age-measured-using-the-glycan-age-index

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DOI - https://doi.org/10.18632/aging.104060

Full text - https://www.aging-us.com/article/104060/text

Correspondence to: Gordan Lauc email: glauc@pharma.hr

Keywords: biological age, glycan age, estrogen, aging biomarkers, glycosylation

About Aging-US

Launched in 2009, Aging-US publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging-US go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways.

Please visit our website at http://www.Aging-US.com​​ or connect with us on:

SoundCloud - https://soundcloud.com/Aging-Us
Facebook - https://www.facebook.com/AgingUS/
Twitter - https://twitter.com/AgingJrnl
Instagram - https://www.instagram.com/agingjrnl/
YouTube - https://www.youtube.com/agingus​
LinkedIn - https://www.linkedin.com/company/aging/
Pinterest - https://www.pinterest.com/AgingUS/

Aging-US is published by Impact Journals, LLC please visit http://www.ImpactJournals.com​​ or connect with @ImpactJrnls

Media Contact
18009220957
MEDIA@IMPACTJOURNALS.COM

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