Bioprocessing

Teach Me in 10

As the global biopharmaceutical industry continues to grow, there is a need for innovative solutions that accelerate development and manufacturing workflows. Label-free protein analysis offers unique advantages for characterizing the biomolecular interaction kinetics of therapeutic candidates during this process. The Sartorius Octet® Label-Free Platform has become an industry leader for its bio-layer interferometry (BLI)-based systems for label-free, real-time analysis.

Recently, the platform has expanded to include the next-generation surface plasmon resonance (SPR)-based instrument, Octet® SF3, making Sartorius the only company to offer both label-free technologies to its customers.

In this episode of Teach Me in 10, we speak with Helge Schnerr, global campaign manager at Sartorius, about the motivation behind this move, the game-changing features on the SF3 and how it all translates to empowering scientists.

For more information, visit https://www.sartorius.com/octet-SPR.

Powered and Prepared for Your Next Label-Free Challenge With Dr. Helge Schnerr

Aging (Aging-US)

Aging (Aging-US) published this trending research perspective in Volume 14, Issue 7, entitled, “Heterochronic parabiosis: a valuable tool to investigate cellular senescence and other hallmarks of aging” by researchers from the Institute on the Biology of Aging and Metabolism, University of Minnesota, Minneapolis, MN; Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN; Department of Molecular Pharmacology and Medicine, Albert Einstein College of Medicine, Bronx, NY; Institute for Aging Research, Albert Einstein College of Medicine, Bronx, NY.

DOI - https://doi.org/10.18632/aging.204015

Corresponding authors - Matthew J. Yousefzadeh - myousefz@umn.edu, and Derek M. Huffman - derek.huffman@einsteinmed.org

Abstract

Parabiosis is a well-established method to facilitate a shared blood supply between two conjoined animals. In particular, the pairing of mice of dissimilar ages, termed heterochronic parabiosis, has been used extensively for differentiating cell autonomous and non-autonomous mechanisms of aging. Analysis of heterochronic parabionts also has helped to identify individual circulating factors that may act as either pro- or anti-geronics. Heterochronic parabiosis also has proven to be a valuable experimental system to evaluate the effects of specific hallmarks of aging on the process of aging. For example, heterochronic parabiosis was used recently to examine whether cellular senescence was driven via cell autonomous and/or non-autonomous mechanisms. As anticipated, markers of cellular senescence were elevated in old isochronically-paired mice relative to young controls. However, compared to old isochronically paired mice, the senescent cell burden was reduced in multiple tissues of old parabionts joined with young mice. This suggests that the rejuvenation of cells and tissues in old mice by exposure to young blood could be mediated, in part, through suppression or immune clearance of senescent cells. Conversely, young heterochronic parabionts showed increased markers of cellular senescence, demonstrating that exposure to an old circulation is able to drive senescence through a cell non-autonomous mechanism(s), likely contributing to accelerated aging in the young mice. Thus, heterochronic parabiosis is still an important methodology that should continue to be leveraged for evaluating other hallmarks of aging and their mechanisms.

Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.204015

Keywords - aging, cellular senescence, heterochronic parabiosis, geroscience

About Aging-US

Launched in 2009, Aging-US publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging-US go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways.

Please visit our website at http://www.Aging-US.com​​ and connect with us:

SoundCloud - https://soundcloud.com/Aging-Us
Facebook - https://www.facebook.com/AgingUS/
Twitter - https://twitter.com/AgingJrnl
Instagram - https://www.instagram.com/agingjrnl/
YouTube - https://www.youtube.com/agingus​
LinkedIn - https://www.linkedin.com/company/aging/
Pinterest - https://www.pinterest.com/AgingUS/

Aging-US is published by Impact Journals, LLC: http://www.ImpactJournals.com​​

Media Contact
18009220957
MEDIA@IMPACTJOURNALS.COM

Trending With Impact: Heterochronic Parabiosis, Cellular Senescence and Aging

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