Name: Adding a QC Lab to Manufacture Safer, High Quality Extracted Products
Uploaded: 2020-08-07T00:00:00
Duration: 30 min 13 s
Description: Speaking at The Science of Cannabis Extraction Online Symposium in June 2020, Dr Toby Astill from PerkinElmer, discussed PerkinElmer's recent research on Fourier transform infrared spectroscopy (FT-IR) with Attenuated Total Reflectance (ATR) to provide a quantitative estimation of the decarboxylation reaction progress in cannabis extract.

Analytical Cannabis 

The Science of Cannabis Extraction Online Symposium 2020

Speaking at The Science of Cannabis Extraction Online Symposium in June 2020, Dr Toby Astill from PerkinElmer, discussed PerkinElmer's recent research on Fourier transform infrared spectroscopy (FT-IR) with Attenuated Total Reflectance (ATR) to provide a quantitative estimation of the decarboxylation reaction progress in cannabis extract.

Adding a QC Lab to Manufacture Safer, High Quality Extracted Products

Speaking back in June 2020 at The Science of Cannabis Extraction Online Symposium, Kellan Finney of Eighth Revolution presented his innovative talk highlighting how the cannabis extraction industry could improve and progress.

Abstract: Research from a Harvard business study showed that employees and companies are less likely to collaborate and form alliances during tough economic times, and this is no less true in the cannabis space. It will be hard to forecast the true effects that COVID-19 will have on the economy and the cannabis industry as whole, but we know that they’ll be extensive. Prior to the pandemic, the cannabis industry was experiencing consolidation events and severe challenges meeting market expectations, and as the old saying goes, “When it rains it pours.”  Just after the markets had begun to stabilize following the vape crisis of 2019, COVID-19 arrived. Historic evidence suggest agricultural and chemical companies have previously survived challenging times through optimization of their current practices and diversification of revenue streams. The optimization of current practices provides ample opportunity for strategic, external alliances and spurs the drive for internal collaboration. With ever shrinking margins, it will also become necessary to develop alternate means of earning revenue. For cannabis and hemp extraction companies, one avenue that has not been investigated enough is supplementing global chemical feedstocks using waste streams from the cannabinoid extraction and refinement processes. Over the course of this presentation, we will explore how collaboration and alliances are vital for the hemp and cannabis industry as well as the pivotal role the industry could play in creating a sustainable global commodity feedstock. 

Building and Growing Cannabis Extraction Through External Collaboration & Internal Diversification

Speaking in June 2020 at The Science of Cannabis Extraction Online Symposium, Trevor Morones from Control Point discussed how lessons from the food industry can be transferred to the growing cannabis industry.<br/><br/>Food safety culture sets the foundation to obtain and maintain quality with precision consistently. Customer trust, reducing unnecessary costs, and preventing operation downtime are three immediate gains. The current global state of legalization generates opportunities to cultivate, harvest, process, manufacture, and distribute cannabis. Raise the boom with an operational culture generating higher NPS (Net Promoter Scores) and retention. Be the operation legislators seek when developing statutes. Be the leader displaying standards of excellence with the value of food safety. Site-specific training for all team members is the preventative action to reduce outbreak risks and generate positive audit results. Rigorous training programs expand food/product safety knowledge, generate a more robust culture, reduce risk, and prevent contamination. By focusing on how each employee can positively impact safety through their daily actions and contribute to market value and customer satisfaction, employees take on a more reliable safety and excellence culture, resulting in higher Net Promoter Scores (NPS). Measurement is critical to quality control and ongoing excellence. Food Safety Management Systems (FSMS) provide operating structure and validate the process to prove the system is operating as intended. These proven systems operate on a foundation of integrity that mitigates risk throughout the process of a product. No doubt, the learnings there transfer to the cannabis products, especially edibles.

Businesses and Consumers “lost in space”

Speaking at The Science of Cannabis Extraction Online Symposium 2020 in June, Lauren Kaiser of Platinum Sponsor Gilson presented her talk on remediation and purification of cannabinoids from lab to production scale.

Abstract: Centrifugal partition chromatography (CPC) is a liquid-liquid partition chromatography technique that provides an efficient, streamlined workflow for natural product purification. Hemp, grown primarily for industrial purposes, encompasses cultivars of Cannabis sativa that are low in tetrahydrocannabinol (THC) content. Following harvest and extraction, a mixture of cannabinoids, including THC, remains in the valuable product. CPC is then employed to accomplish several key goals: (1) remediate THC to below the legal limit or non-detectable levels, (2) purify minor cannabinoids (CBC, CBN, CBG, etc.) to produce high purity isolates, and (3) remediate pesticides. CPC purification methodology is optimized at the lab and/or pilot scale and linearly transitioned to production scale on a Gilson VERITY CPC Process System. Key advantages of CPC include: no product loss, absence of solid stationary support, easy recycling of solvents to keep operating costs low compared to other chromatography techniques, and flexibility to develop new methods to match evolving goals in an ever-changing market.  

Cannabinoid Remediation and Purification from Hemp by Centrifugal Partition Chromatography 

Keynoting at The Science of Cannabis Extraction in June 2020, Dr Markus Roggen, Founder of Complex Biotech Discovery Ventures presented his fascinating presentation on data analytics in cannabis extraction.

Abstract: The cannabis industry has evolved and now faces common pressures of more established industries. Although, to reduce production costs, increase output and offer new products the old ways of cannabis productions reach their limits. At Complex Biotech Discovery Ventures, we have employed big data analytics to understand extraction processes at a fundamental level and developed insights that previously have been impossible to achieve. Our work helps producers spot inefficiencies in their production, implement better extraction protocols to target specific outcomes or just optimize yields. We achieve this in a minimally invasive manner, analyzing historic data from producers, and in combination with our in-house algorithm we spot a slowly dying pump, certain cultivars that need updated SOPs or can fine-tuning their oil quality. Having access to data of thousands of extraction runs gives us a unrivaled precision in process conditions. CBDV is a young research venture that seeks to add fundamental scientific insights to the field of cannabis production. The collaborative effort of the multidisciplinary research team at CBDV led to a diverse set of insight in every stage of production. Building on these insights, I propose a readjustment of research focus as we often fall into the trap of chasing the shiny objects, while disregarding the fundamentals that form the solid base for success in the long term.

Extraction Optimization and Control with Data Analytics

Speaking at The Science of Cannabis Extraction 2020 Online Symposium in June, Thomas Rosengren of Flower One presented his fascinating talk on boutique cannabis extracts.

Abstract: Liquid Petroleum Gas extraction of Cannabis spp. is an attractive method for derivatization of products for both recreational and medicinal consumers. Generic process flows, consideration of variables affecting outputs, and methods of consumption are presented.  Chromatographic fundamentals applicable to color remediation chromatography (CRC) of boutique concentrates, are discussed. Effects of CRC on morphological outcomes, cannabinoid and terpene profiles are examined.

Morphology of Emergent Boutique Cannabis Concentrates Produced via Liquid Petroleum Gas Extraction

Speaking at The Science of Cannabis Extraction 2020 Online Symposium in June, Keenan Gong of Buchi discussed biomass screening, ethanol recovery distillation, winterization, and finished with a conclusion on how to turn oil formulation to powder using a spray dryer.

This talk will focus on different solutions for each step of the cannabis process workflow:

o	Starting with biomass screening for THCA and CBDA concentration using NIR.

o	Ethanol recovery distillation after Winterization and chromatography.

o	Focus on cannabinoid purification using flash chromatography, highlighting some new unique developments.

o	Turning oil formulations to powder using a spray dryer.



Purification and Pesticide Remediation by Flash Chromatography and Powder Production by Spray Drying

Speaking at The Science of Cannabis Extraction 2020 Online Symposium in June, Heather Despres discussed Good Manufacturing Practices and how they can be applied to cannabis and hemp manufacturing operations.

Abstract: The world of cannabis and hemp manufacturing is continuing to expand and reach more and more consumers. There is a great responsibility in manufacturing these products to ensure the health and safety of not only the consumer but the workers who are making the products. This session will discuss how to apply the principles of Good Manufacturing Practices (GMP) to
cannabis and hemp manufacturing operations as well as discuss options that will enable
operators to be successful with compliance audits.

Adding a QC Lab to Manufacture Safer, High Quality Extracted Products

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Analytical Cannabis

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August 7, 2020

The Science of Cannabis Extraction Online Symposium 2020

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