Name: Behind the Science, ep. 12: My Samples Are Too Dirty For MS
Uploaded: 2016-07-28T00:00:00
Duration: 5 min 32 s
Description: Today our host Jen Fournier is in the lab with the dirtiest, grimiest samples. She knows if she tries to run them on LC-MS as-is, she’d degrade the column, get low sensitivity … and have to clean the mass spectrometer. Is there a better way to start with clean samples?

Waters Corporation

Sample preparation best practices | Behind the Science

Today our host Jen Fournier is in the lab with the dirtiest, grimiest samples. She knows if she tries to run them on LC-MS as-is, she’d degrade the column, get low sensitivity … and have to clean the mass spectrometer. Is there a better way to start with clean samples?

Behind the Science, ep. 12: My Samples Are Too Dirty For MS

Let's get ready to cleanup! Host Jen Fournier throws down a battle episode pitting several solid-phase extraction (SPE) techniques against matrix effects for highly complex samples. We go to the wet lab where we've matched up research scientists Scott McCall and Xin Zhang. The deciding factors: robustness, minimal variability, and low matrix effects.

Behind the Science, ep. 13: SPE vs. matrix effects – battle episode!

Clinical laboratories that are assessing dosage of drugs used in pain management often face lengthy, complicated analytical workflows. In this episode of Behind the Science, host Jen Fournier talks with two of our scientists about how to streamline sample preparation. John Danaceau demonstrates a method using a water-wettable sorbent that eliminates evaporation, reconstitution, and sample transfer steps prior to LC-MS analysis. His faster SPE method delivers both high and reproducible sample recovery rates for accurate quantitative analysis.

Behind the Science, ep. 14: Can SPE methods be fast and simple?

In this episode of Behind the Science, chemists Kim Tran and Michael Young take us through a comparison of two SPE methods used prior to LC-MS/MS analysis to test unwanted compounds that may be found in a very important sample... infant formula. Let’s do it for the children!

Behind the Science, ep. 12: My Samples Are Too Dirty For MS

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Waters Corporation

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July 28, 2016

Sample preparation best practices | Behind the Science

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