life-science

One-Stop De Novo Antibody Sequencing Services
Sequencing of the V and J and C Segments by DASS
The V and J and C gene segments of antibodies are available in public databases. However, during the maturation of an antibody, the B cell introduces hypermutations into the sequence to optimize the affinity. Our mapping algorithm is error tolerant and can match the "mutated" peptides to the corresponding germline, reliably. http://www.creative-biolabs.com/next-generation-antibody-sequencing.html


antibody de novo sequencing

Humanization is important for reducing the immunogenicity of monoclonal antibodies derived from xenogeneic sources (commonly rodent) and for improving their activation of the human immune system. Since the development of the hybridoma technology, a large number of rodent monoclonal antibodies with specificity for antigens of therapeutic interest have been generated and characterized. http://www.creative-biolabs.com/antibody-humanization.html<br/>

Antibody Humanization

Phage display is one of the most powerful and widely used laboratory technique for the study of protein-protein, protein-peptide and protein-DNA interactions. This technology is mainly based on displaying the interest protein (peptides, antibodies, scaffolds or others) on the surface of employing phage and then be used to interrogate the constructed libraries containing millions or even billions of displayed phages. Theoretically, phage display is an exogenous gene expression method which the gene encoding the interest protein is inserted into bacteriophage coat protein gene then displaying the interest protein on the phage surfaces, resulting in a connection between genotype and phenotype. https://www.creative-biolabs.com/phage-display-service.html

Antibody Library Screening

Antibody Phage Display Library

Antibody libraries are constructed by the genomic information coding for antibody variable domains, which can be derived from B cells of immune or naïve donors. Antibodies are the first proteins which were successfully displayed on the surface of phage by fusing the coding sequence of scFv or Fab to the coat protein. Due to the smaller size, scFv libraries are genetically more stable than Fab libraries, while Fab libraries lack the tendency to form higher molecular weight species, such as dimers and trimers, which can simplify the selection and characterization. Through binding the specific target, the interest antibody can then be eluted and retrieved. https://www.creative-biolabs.com/phage-display-service.html


Bacterial Display Technology

Yeast surface display (or simply, yeast display) is a potent protein engineering tool for a broad range of biotechnology and biomedical applications and is widely used for in vitro protein evolution. Yeast surface display has been regarded as an alternative method for isolating and engineering antibody fragments (Fab, scFv) from immune and non-immune libraries, and has been applied to isolate recombinant antibodies with binding specificity to a variety of proteins, peptides, small molecules and T cell receptors. https://www.creative-biolabs.com/yeast-display-services.html


custom yeast display service

In Vitro Diagnostics (IVD) are tests used to detect and in diagnosis of disease, infections or other medical conditions, including a determination of the state of health, in order to cure, mitigate, treat, or prevent disease or its sequelae. They’re intended for use in the collection, preparation, and examination of specimens taken from the human body.

Common uses for in vitro diagnostics including but not limited to disease screening, infections detecting, therapeutic monitoring, ensuring blood is safe to be used in transfusions, and recognizing of allergies and the measurement of hormones and other biological markers in body specimen.

life-science

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