Teach Me in 10 guests explore a variety of topics, from the latest developments in gene editing technology, neuroscience and cancer, to writing a scientific paper or applying for your first academic position. We invite you to learn from their insights and engage with the videos as you learn from the experts.

Teach Me in 10

Innovations resulting from science, technology, engineering and mathematics (STEM) fields have positively touched nearly every aspect of human life. Promoting and supporting diversity across areas including gender, age, race, professional sectors and scientific disciplines plays a key role in advancing scientific understanding. Yet, there is no blueprint for bringing diversity to academia and the world of science. Meaningful diversity will not be achieved unless we invest in efforts to make STEM more accessible and inclusive for women and underrepresented populations. 
In this episode of Teach Me in 10, Dr. Jeanita Pritchett, who has a deep-rooted passion for helping others find excitement in STEM and considers herself a "Jane of All Trades", will speak about what diversity means and why DEI policies and practices are an important factor in optimizing the science ecosystem. She will also explain how she seeks to address the question of what everyone can do to help create a more inclusive environment. 
Dr. Pritchett will share steps that need to be taken to effect real, tangible and lasting change in the scientific community, or what Extraordinary Grace calls “The Change Hypothesis”. This hypothesis is the result of more than 1,300 scientists and researchers like yourselves from around the globe opening-up to Grace with their raw and honest experiences when she asked, "Can I be a scientist, and can I still be me?”


Diversity, Equity and Inclusion in STEM With Dr. Jeanita Pritchett

Flow cytometry is a technique that is adopted to both detect and measure characteristics of a population of cells, or particles. As a widely used method, flow cytometry has several different applications. 
Watch this Teach Me in 10 video to hear an introduction to flow cytometry with Dr. Eric Yager from the Albany College of Pharmacy and Health Sciences.

An Introduction to Flow Cytometry With Dr. Eric Yager

In this Teach Me in 10 episode, we are joined by Dr. Andrew Mtewa, senior lecturer in chemistry at the Malawi University of Science and Technology.

Mtewa discusses the properties that make a molecule a potential drug candidate worthy of pursuing, factors that help improve drug absorption and drug distribution in the body as well as the role of metabolism on drug action and rates.


Andrew Mtewa suggests the resources below for further reading:
•https://www.nature.com/articles/nrd1032
• https://www.sciencedirect.com/science/article/abs/pii/S1056871900001076?via%3Dihub
• https://www.sciencedirect.com/science/article/abs/pii/S1359644618303301
• https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350845/

ADMET in Drug Discovery With Dr. Andrew Mtewa

In this Teach Me in 10 episode, we are joined by Dr. Eric Wengert, postdoctoral fellow at The Children’s Hospital of Philadelphia. 

Dr. Wengert will be discussing epilepsy, the neurological disorder caused by hyperexcitability and synchrony in the brain, which manifest as behavioral seizures. 

While there are antiseizure medications available, many patients become refractory to available treatments and even those in which seizures are controlled have to deal with significant adverse side effects. 

For this reason, scientists are actively investigating new ways to better prevent seizures with fewer and less severe side effects. Gene therapy, which seeks to modify brain activity by altering gene expression directly rather than protein function, represents a more targeted way of intervening in the brain. 

One of these approaches, Targeted Augmentation of Nuclear Gene Output (TANGO), seeks to boost gene expression of the SCN1A gene to treat a severe genetic epilepsy syndrome called Dravet Syndrome. In a mouse model of Dravet Syndrome, a single treatment with TANGO rescues the impaired excitability of inhibitory interneurons, reduces seizure frequency and prolongs survival. 

Gene therapy approaches like TANGO hold great potential for treating epilepsy and improving the lives of patients, as Dr. Wengert explores in this video.

Gene Therapy To Treat Epilepsy With Dr. Eric Wengert

In this Teach Me In 10 episode we are joined by Michiel Fokkelman, head of high throughput screening at Crown Bioscience.
We will discuss the concept and definitions of high content imaging, both for 2D and 3D cell culture systems. These rich and extensive morphological readouts provide phenotypic data showing the cellular response(s) to a compound or new potential drug. Michiel then explores the use of 3D-cultured organoids and how these are utilized in drug discovery and pre-clinical drug development using high content approaches. Finally, we will then look at the role of lab automation, essential in enabling high throughput and HCI-based phenotypic screening, and how you can benefit from these technologies.

High-Throughput and High-Content Screening in Organoids and 3D Models With Michiel Fokkelman

3D cell culture systems are gaining interest in the scientific community as they provide more physiologically relevant information and more predictive in vivo data. For more than 25 years, Corning Life Sciences has delivered innovative educational tools and protocols that have advanced the science of 3D cell culture and supported the widespread adoption of these models.

In this Teach Me In 10 episode one of Corning’s customers, Dr. Joseph Regan, shares information from a recently published protocol for the isolation and functional validation of label-retaining quiescent colorectal cancer stem cells from patient-derived organoids for RNA-seq.

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