PerkinElmer 

The MuviCyte system is designed to operate inside your incubator, so you can maintain your cells under optimal conditions, keeping them healthy for weeks at a time. Controlled by an external PC, you can observe your cells remotely, which helps to keep the culture chamber at optimum levels of temperature, CO2, and humidity. The automated operation allows you to focus on your science while the instrument runs unattended. With three-color fluorescence imaging, z-stacking, and stitching capabilities, you can perform a wide range of assays in a variety of culture vessels, e.g. chamber slides, petri dishes, flasks, microplates. Automated imaging, over hours to days, means your assays can be run at much higher throughput than with a traditional microscope. The system has built-in image analysis software for assays such as cell health and viability, transfection efficiency, reporter gene, apoptosis and proliferation, and optional software available for scratch wound and spheroid assays. The flexible movie-making software provides a great way to gain more realistic and meaningful insights into cell behavior, functions, and responses. Features and benefits •	Operates inside incubator - Provides optimal environmental conditions to keep cells healthy for long-term kinetic assays or use a hypoxia incubator for imaging under hypoxic conditions. •	Benchtop operation - Use the instrument on the bench with the lid (included) or inside a cell culture incubator. •	Open design - Provides flexibility to use the culture vessels of your choice, such as microfluidics platforms. •	Three-color fluorescence plus brightfield imaging - Flexibility to work label-free or select from a wide range of dyes and fluorescent proteins, and you can save time by analyzing more cell features using multiple markers at the same time. •	4x, 10x, and 20x (LWD) objectives, digital zoom - Flexibility to work with a range of magnifications for different cell applications. •	Image-based autofocus - uses image features to select the focus position. The focus is dependent on the cells, not the sample carrier, giving you a stable focus on the cells. •	Custom autofocus - you can focus on defined structure within your cell sample by adjusting the reference z-height for the autofocus. •	Unlimited and flexible imaging positions (FOVs) within wells - Choose imaging positions freely within the well to capture cells of interest, from small cell colonies to entire wells, without a pre-defined grid. •	Image stitching - Create a stitched image, enabling analysis of larger objects such as tissue sections, stem cell colonies, or an entire well. •	Z-stacking - Extends the range of imaging in the z-direction for 3D objects or thicker samples such as spheroids. •	Automated operation - Delivers faster imaging and is less prone to error than a manually operated research microscope. •	Image quantification software for commonly used assays - Easier and faster than with a manual microscope, and more reliable quantification than by manual methods. •	Movie Maker - Enables easy moviemaking and has multiple movie modes (single, sequence, and matrix) enabling you to compare multiple wells side by side, interpret cell responses. •	Annotation list - Annotate your areas of interest on the images while setting up the measurement to help you find important positions over time. Ensures you can find specific items of interest, e.g. particular cells, stem cell colonies or regions of interest on tissue slices. •	Open data format - Easily access and share data with colleagues. You can set the image format to TIF, PNG, JPEG or BMP. •	Global on-site service - Receive on-site service globally from a local service engineer to minimize instrument down time. Typical applications and assays •	Cell health and viability •	Transfection efficiency •	Scratch wound •	Spheroid analysis •	Apoptosis •	Cellular localization •	Neurite outgrowth •	Fluorescent cell counting •	Proliferation •	Stem cell monitoring •	Cell morphology

Never Miss a Moment with the MuviCyte Live-Cell Imaging System from PerkinElmer

The Operetta CLS high-content analysis system combines speed and sensitivity with powerful and intuitive data analysis. The Operetta CLS system is part of PerkinElmer's comprehensive HCS portfolio – from HCS systems and microplates to automation and informatics. At the core of the Operetta CLS™ high-content analysis system is a light path that ensures efficient excitation of your samples and careful collection of emitted signals. [b][go/][/b] Powerful, stable 8x LED light source for optimal excitation of your fluorophores and confidence in results [b][go/][/b] Proprietary automated water-immersion objectives with very high numerical aperture enabling high resolution and fast read times with minimal photodamage [b][go/][/b] Confocal spinning disk technology provides a fast and gentle imaging process, enabling efficient background rejection, live cell experiments, and 3D imaging [b][go/][/b] Large format sCMOS camera delivers low noise, wide dynamic range, and high resolution – perfect for sensitive and quantitative measurements at short exposure times [b][go/][/b] User accessible bar-coded emission filters provide flexibility, sensitive imaging and error-free operation [b][go/][/b] Simple, powerful Harmony imaging and analysis software for easy set-up of assays, automation of experiments, image acquisition, data analysis, and storage and retrieval of results

Operetta CLS High-Content Analysis System 

What if you could get high quality results without the hassle? Our wide range of assay solutions makes it easier to take an orthogonal approach to your cell-based assays, glean more biologically relevant information, and get to breakthroughs faster. Innovative reagent technologies like: AlphaLISA® SureFire® Ultra™, AlphaLISA® SureFire® Ultra™ Multiplex, AlphaScreen® SureFire®, LANCE® Ultra TR-FRET, and DELFIA® TRF assays – not to mention our reporter gene assays and complete line of industry leading radiochemicals, combined with our highly reliable, high-performance multimode readers provide everything you need to bring about the next big breakthrough in cell signaling and pathway analysis. 

On the Pathway to Discovery, All Signals are Clear

The most physiologically relevant processes and insights are happening in 3D. So see what you’re missing with the new capabilities of Harmony® 4.8 software for imaging, analysis, and visualization of complex 3D cell models. 
With Harmony 4.8, you can: 
•	Accelerate 3D image acquisition and analysis
•	Better understand spatial relationships
•	Discover new perspectives not visible in 2D
•	Measure volume and morphology in 3D


Now you can visualize and analyze complex 3D cell models – with Harmony 4.8 software

Discover how scientists are harnessing the body's own immune system to fight cancer, and how they are using quantitative pathology solutions from PerkinElmer to better understanding the interactions between the immune system and cancer, and to identify biomarkers for translational research. 

Fighting Cancer with Immuno-oncology and Quantitative Pathology

Accelerate drug discovery workflows with state-of-the art imaging and detection instruments, assay technologies, reagents, versatile automation systems, and powerful informatics solutions that work together to ensure consistent, accurate, physiologically relevant results. Wrest more meaning from your findings with PerkinElmer's one-of-a-kind analytics, and amplify your phenotypic or target-based screens to identify hits and lead compounds in small and focused or high-throughput volumes.

PerkinElmer

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