Biotech Videos 

Immunotherapy has become a novel, powerful clinical strategy of cancer treatment. The number of immunotherapy drug approvals is increasing, with numerous therapeutics in clinical and preclinical development. 
https://www.creative-biolabs.com/drug-discovery/therapeutics/target-discovery-for-cancer-immunotherapy.htm

Immune Cell Migration in Cancer and Immunotherapy

Genome editing, also known as gene editing, is the insertion, deletion or replacement of DNA at a specific site in the genome of an organism or cell. Gene silencing refers to prevent the expression of a certain gene. Both of these two approaches have been effectively used in a wide variety of tissues and organisms to study how genome influences phenotype.
https://www.creative-biolabs.com/drug-discovery/therapeutics/gene-manipulation.htm



Gene Manipulation

Transposons-based genetic strategies have been established in vertebrate species over the last decade. The major advantage of these strategies is that they facilitate analysis of gene function in an easy, controlled, and scalable manner, thereby avoiding some of the limitations of the classical DNA microinjection method. 
https://www.creative-biolabs.com/drug-discovery/therapeutics/transposon-mediated-genome-manipulation.htm

Gene Delivery Systems

Rational optimization of the antibody molecule by Fc engineering represents a major area of translational research to further improve this potent therapeutic option. 
https://www.creative-biolabs.com/drug-discovery/therapeutics/effector-function-improvement-via-antibody-skeleton-engineering.htm

Effector Functions-enhanced Antibodies

Antibody protein is initially digested into overlapping peptides using various trypsin
Digestion with LC-MS/MS, then fragmentation optimization
Overlapping peptides are characterized by de novo peptide sequencing
Automated antibody sequence assembly using characterized peptides
Data analysis is performed using state-of-the-art computational algorithms that efficiently derive the amino acid sequence of the digested peptide
https://www.creative-biolabs.com/next-generation-antibody-sequencing.html

De Novo Antibody Sequencing Service 

Creative Biolabs provides professional custom service packages to fully meet client's specific needs in drug development journey, especially for various antibody related modalities (monoclonal antibody, single domain antibody, bispecific antibody, multi-specific antibody, ADC, CAR T, etc.). Creative Biolabs generates antibodies against different targets ranging from hapten, soluble protein, membrane protein and whole cells, using well established multiple platforms such as hybridoma, phage display and B cell sorting for novel antibody discovery, enabling to provide the most suitable approach to the client's project. What makes Creative Biolabs distinguished from competitors is that we proceed clients' projects according to their specific demands in quality, timeline and budget, supporting researchers across different therapeutic areas. Clear, open and regular communication with customers is as important to our success as our in-depth scientific knowledge. Having carved a unique niche by scripting many such success stories, Creative Biolabs' services are expanding from antibody discovery and development to a broader area, including immunotherapy and cell and gene therapies.
https://www.creative-biolabs.com/

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