Mutant library

Genomic engineering in cell lines is a versatile tool for studying gene function, designing diseases models, biopharmaceutical research, drug discovery and many other applications. CRISPR (Clustered Regulatory Interspaced Short Palindromic Repeats)/Cas9 systems is a newly developed yet the most popular method for <a href="https://www.creative-biogene.com/Services/Stable-cell-line-generation/Custom-Genome-Editing-Cell-Lines.html">genome editing</a>. It has been widely used in current biology, functional genome screening, cell-based human hereditary disease modeling, epigenomic studies and visualization of cellular processes.

Stable Knockout Cell Line Generation

The <a href="https://www.creative-biogene.com/support/ABC-Transporters-Family.html">ABC transporter</a> superfamily is a well-characterized protein family, but the substrates and roles of a number of these proteins in human disease are unknown. Substrate specificity has mostly been inferred from the identification of metabolites/compounds that accumulate in humans with specific diseases and in knockout mouse models.

ABC Transporters

<a href="https://www.creative-biogene.com/support/genome-editing-generation-of-reporter-stem-cells.html">Reporter stem cell lines</a> are valuable models which enable noninvasive, live monitoring of marker onset and expression in a cell-specific manner. Some methods have been used to derive such cell lines based on lineage promoter-driven reporter expression. A more regulated expression achieved with a reporter knock-in into the endogenous promoter loci was less utilized due to the associated technical difficulty. While new advances in genome-editing technologies have lowered these barriers for creating knock-in reporter lines.

Reporter Stem Cells Generation

IntegrateRNA provides researchers with accurate and complete transcriptome information that not only recognizes new transcripts, alternative splicing, and gene fusion events but also quantifies gene expression and differential gene expression analysis between different sample groups. 

https://integraterna.creative-biogene.com/service/mrna-sequencing-service.html

mRNA Sequencing

CRISPR/Cas9 Plasform has extensive experience in gene/genome editing. We can provide you with multiple solutions covering the entire process of using the CRISPR system, high-quality end-to-end services, and marketable products, including single sgRNA/sgRNA library design/synthesis, CRISPR vector construction, bioinformatics analysis, etc.

https://www.creative-biogene.com/crispr-cas9/service/crispr-basic-services.html

CRISPR Basic Services

Creative Biogene provides commercial and research cell line based on its proprietary expression vector, high throughput cell screening technologies and serum, animal components free process without any adaptation issue in a significantly reduced timeline.

https://www.creative-biogene.com/Services/Stable-cell-line-generation

Mutant library

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