itraq labeling

Equipped with state-of-the-art technologies such as high-performance liquid chromatograph coupled to tandem mass spectrometry (LC-MS/MS) and advanced computational algorithms, Creative Proteomics can offer accurate and fast antibody de novo sequencing service customized to your needs. De novo sequencing of antibodies refers to the analytical process of deriving the amino acid sequence of an antibody and discovering any associated post-translational modification without knowing DNA or protein sequence beforehand. More at https://www.creative-proteomics.com/services/de-novo-peptides-proteins-sequencing-service.htm

De Novo Sequencing

Peptide Mass Fingerprinting (PMF) is an analytical  technique for identifying unknown protein. Proteins to be identified is first  digested into peptides, whose absolute mass can be accurately analyzed by a  mass spectrometer, such as MALDI-TOF or ESI-TOF. MALDI is more preferred in PMF  analysis, as it has a wide sequence coverage and can analyze a large amount of  sample at the same time.  
More can be reached at https://www.creative-proteomics.com/services/peptide-mass-fingerprinting-pmf.htm

peptide mass fingerprinting for protein identification

Phosphorylation is an important covalent post-translational modification (PTM) in cell signaling pathways. This modification is a reversible process, and is catalyzed by protein kinases. Study showed that over 30% of eukaryotic proteins are subject to phosphorylation. 
More can be reached at https://www.creative-proteomics.com/services/phosphorylation.htm

Protein Phosphorylation

Glycosylation mainly refers to the enzymatic process that attaches glycans to proteins, lipids, or other organic molecules. It is the most common protein post-translational modifications (PTM). Glycosylation analysis is very challenging because of the complexity and the isobaric nature of attached glycans. With the increasing application of protein therapeutics, such as monoclone antibodies, glycoproteins, hormones, cytokines and clotting factors in clinical practice, routinely monitoring the N-glycosylation of proteins is becoming more and more popular.

More can be reached at https://www.creative-proteomics.com/services/n-glycan-profiling-service.htm

Glycan Analysis

Post-translational modification (PTM) refers to the covalent, usually enzymatic modification of proteins, and protein process during or after protein biosynthesis. Protein post-translational modification (PTM) increases the functional diversity of the proteome by the modifying proteins with functional groups, such as phosphate, acetate, amide groups, or methyl groups, and influences almost all the aspects of normal cell biology and pathogenesis. More on https://www.creative-proteomics.com/services/overview.htm

PTM analysis

Creative Proteomics offers iTRAQ protein quantification service suited for unbiased untargeted biomarker discovery. Relative quantification of proteins for biomarker discovery in complex mixtures by mass spectrometry can easily and quickly be achieved using iTRAQ technology. iTRAQ is ideally suited for comparing normal, diseased, and drug-treated samples, time course studies, biological replicates and provides relative quantitation. More on https://www.creative-proteomics.com/services/itraq-based-proteomics-analysis.htm

itraq labeling

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