Peptide Science

Solid-phase synthesis is a technology by which the synthesis of a peptide is simplified. The chemistry for synthesis on a solid support is the same as that for synthesis in solution, except that the protector of the carboxy terminus is linked to an insoluble support, either directly or indirectly. https://www.creative-peptides.com/services/custom-peptide-synthesis.html


Solid Phase Synthesis Creative Peptides

Glucagon is a peptide hormone, produced by alpha cells of the pancreas, that raises the concentration of glucose in the bloodstream. Its effect is opposite that of insulin, which lowers the glucose concentration. Glucagon is a 29-amino acid peptide hormone that is synthesized in pancreatic α cells from the proglucagon precursor by prohormone convertase 2 (PC2). The primary structure of glucagon is identical in most mammals, with the exception of some amino acid differences in guinea pigs and non-mammalian vertebrates. https://www.creative-peptides.com/research-areas/peptides-in-diabetes.html


Glucagon and Glucagon signaling-Creative Peptides

Neoantigens is a class of HLA-bound peptides that arise from tumor-specific mutations. They are highly immunogenic because they are not present in normal tissues, thus can be used as biomarkers differentiating cancer cells from normal cells. It has been shown that recognition of these individual-specific neoantigens opens a new door for cancer immunotherapy. https://www.creative-peptides.com/services/neoantigen-peptides-vaccine-service.html


Neoantigen Vaccine Creative Peptides

Cellular uptake of biologically active molecules is an important subject in scientific research. While application of cell-penetrating peptides (CPPs, also known as Protein Transduction Domains) for delivering biologically active molecules across cellular membranes into cells was an important breakthrough in cell biology, and the research in this field has gained much attention in recent years. Most CPPs are relatively short peptides that consist of less than 40 amino acids and are able to enter cells through various ways, including endocytosis and energy-independent pathway. Because of strong cell penetrating capability, CPPs are further able to assist in the intracellular delivery of covalently or non-covalently conjugated bioactive cargos, ranging from small chemical drugs and nanoparticles to large plasmid DNA. https://www.creative-peptides.com/services/cell-penetrating-peptides-synthesis-services.html


Cell penetrating peptides-Creative Peptides

PNAs, or peptide nucleic acids, is an analogue of oligonucleotide in which sugar-phosphate backbone has been replaced by a polyamide chain. Due to the unique backbone of PNA, it can be used in same applications as conventional DNA/RNA. Comparing with DNA, PNAs are neutral in charge, chemically more stable and resistant to DNases and proteases, as well as remaining high sequence specificity, binding activity and lower salt sensitivity. PNAs have been widely used in molecular diagnostics and therapeutics, such as fluorescent in situ hybridization (Fish), single nucleotide polymorphisms (SNPs) detection and antisense therapy. https://www.creative-peptides.com/services/peptide-nucleic-acid-synthesis-service.html

The application of Peptide nucleic acids Creative Peptides

For the last few decades scientist have been researching the involvement of the immune system in cancer development to discover potential cure. Immune cells has been known to play an important role in regulating tumor progression, thus stimulating immune reactions towards tumors can be an attractive therapeutic targeting cancer. More and more clinical data has been shown positive signs of immunotherapy and cell therapy as potential cure for cancer. https://www.creative-peptides.com/research-areas/immunotherapy-cell-therapy.html

Peptide Science

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