Oxford Nanopore Technologies

Oxford Nanopore sequencing devices enable direct, real-time analysis of short to ultra-long fragments of DNA/RNA in fully scalable formats. 

It’s possible to target regions of DNA in real time using adaptive sampling on nanopore devices. The nanopore has the ability to read the strand sequence in real time, if it is not the strand of interest, the strand is ejected, but if it is, the nanopore recognises this and continues to read the strand. Researchers then get more of the sequence they are interested in within a shorter period of time, allowing faster and easier analysis. 

Adaptive Sampling: Target Regions of DNA in Real Time

Loss of biodiversity is an urgent problem. Oxford Nanopore launched ORG.one to support faster, more localised sequencing of critically endangered species. Using portable nanopore sequencing, biologists can rapidly sequence species close to the sample’s origin.

Why nanopore sequencing technology?
Oxford Nanopore devices sequence DNA/RNA directly, providing rich data that can be streamed in real time for rapid insights. The technology is fully scalable, from pocket to population scale, and makes it possible to sequence short to ultra-long DNA/RNA fragments. With this new generation of high-performance nanopore-based sensing technology, Oxford Nanopore aim to bring the widest benefits to society through enabling the analysis of anything, by anyone, anywhere.

[url][link]https://org.one/oo[/link][name]Learn more about ORG.one[/name][/url]
[url][link]https://nanoporetech.com/how-it-works[/link][name]Learn how nanopore sequencing works[/name][/url]

ORG.one: supporting sequencing of critically endangered species

Flongle is an adapter (flow cell dongle) for MinION or GridION that enables direct, real-time DNA or RNA sequencing on smaller, single-use flow cells. Providing access to sequence data as soon your experiment starts, Flongle is designed to be the quickest, most accessible and cost-efficient sequencing system for smaller tests and experiments.

Flongle - for rapid DNA/RNA sequencing tests in any environment

Oxford Nanopore’s long-read cDNA sequencing solutions allow researchers to sequence millions of whole transcripts end-to-end in single reads. This enables users to simultaneously perform accurate isoform-level transcriptome characterisation, and  differential gene expression profiling  without any of the compromises on cost, quantitation, computational or workflow complexity required to achieve this on other short or long read sequencing platforms.

https://store.nanoporetech.com/cdna-and-direct-rna/

'109' cDNA kits from Oxford Nanopore

Oxford Nanopore Technologies has developed nanopore-based DNA and RNA sequencing technology designed to provide on-demand biological information, to any person, in any environment. 

Protein nanopores are tiny holes, that in nature form gateways across membranes. In our technology, protein nanopores are embedded into a synthetic membrane bathed in an electrophysiological solution and an ionic current is passed through the nanopores.  

As molecules such as DNA or RNA move through the nanopores, they cause disruption in the current. This signal can be analysed in real-time to determine the sequence of bases in the strands of DNA or RNA passing through the pore. 

Find out more: https://nanoporetech.com/how-it-works

Introduction to nanopore sequencing

PromethION offers the same real-time, long-read, direct DNA and RNA sequencing technology as MinION and GridION, on a much larger scale. PromethION is a standalone benchtop system designed to run up to 48 flow cells at any time. Integrated compute allows real-time basecalling and onward analysis. No capital expenditure is required. PromethION is designed to enable sub-$1,000 nanopore-only human genomes. Find out more: https://nanoporetech.com/products/promethion

Oxford Nanopore Technologies

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