Radleys

Steve Bendefy explains the benefits of overhead stirring over magnetic stirring on a small scale - typically less than 500 ml reaction volume. 

Steve discusses techniques commonly used in process development and the advantage of using overhead stirring as early as possible in the research process to overcome issues associated with solids being influenced by the effect of a magnetic stirrer bar and how to overhead stir viscous reaction mixtures on a small scale. 

Do you use viscous materials that need overhead stirring? Scale up and down with our Reactor-Ready jacketed lab reactor system that mimic 10,000 L reactors used on plant scale. 

Radleys' Reactor-Ready jacketed laboratory reactor system, is designed as a universal jacketed lab reactor work station with a range of easily interchangeable vessels from 100 ml to 5 litres which can be configured to suit the chemistry and scale needed for each project. 

Easy to use, this one unique framework can replace many jacketed lab reactors, saving money and fumehood space by using one circulator with multiple setups. 

Reactor-Ready is ideal for organic chemistry, process chemistry, process development, medicinal chemistry, R&D research, polymer chemistry, academic research, API manufacture and CRO or contract synthesis. 

Reactor-Ready features: 
• Rapid vessel exchange with quick-release vessel clamps and wide bore hose couplings. 
• Range of standard (single and vacuum jacketed) glass reactor vessel – 250 ml to 5 L. 
• Range of process (single and vacuum jacketed) glass reactor vessel - 100 ml to 5 L Process Vessels. 
• Mimic the geometry of plant scale reactors and feature a 1.25 to 1 ratio of internal height to internal diameter, with dish shaped bottom. 
• DN100 vessel flange. 
• Accepts all leading brands of overhead stirring and allows easy, tool free adjustment. 
• Compact stainless-steel framework accepts all vessel sizes. 
• Self aligning stirrer coupling engages without the need for tools. 
• Temperature range: -70 ˚C to +230 ˚C (thermofluid temperature). 
• Innovative hose manifolds allow easy thermofluid drain down. 
• Wide range of accessory glassware including condensers, dropping funnels etc. 
• Optional software allows you to log and control 3rd party devices. 

Reactor-Ready also offers a range of accessories such as condensers, temperature probes, glass and PTFE lids, PTFE impellers and reflux divider kits. You can also automate your jacketed lab reactor system with our AVA Lab Control Software which controls and data logs all the periphery devices connected to your jacketed lab reactor, such as overhead stirrers, circulators and gravimetric additions modules for accurate liquid dosing. 

For more information visit: https://www.radleys.com/range/reactor...
To book a demo visit: https://calendly.com/jacketed-lab-rea...


Instagram: https://www.instagram.com/radleys_che...
Facebook: https://www.facebook.com/radleyschemi...
LinkedIn: https://www.linkedin.com/company/77309​
Twitter: https://twitter.com/Radleys​

#medicinalchemistry #magneticstirrerhotplate #drugdiscovery

Benefits of overhead stirring on a small scale in chemistry process research and development

Dr Keren Abecassis shows how to use vials and tubes with Radleys Mya 4 Reaction Station.

The Mya 4 Reaction Station accommodates a wide range of glassware, including a variety of tubes and vials such as: HPLC vials, scintillation vials, Biotage tubes for sealed reactions, GreenHouse tubes and Carousel 12 tubes.

To use a certain type of vial, pick the right aluminium insert and drop it in one of the zones of your Mya 4. Then place the required number of vials in the insert, add the recommended stirrer bars, and caps if using.

All the tubes/vials are now positioned in a circle at the same distance from the magnet in the centre, which means the stirring will be same in all positions.

You can use your own tubes and vials, as long as you have the right aluminium insert. And if we don’t already have an insert for your usual tubes/vials, we can do custom ones.

Heating and cooling several tubes and vials is easy with the Mya 4 Reaction Station; especially as it accommodates a variety of commonly used options.

The Mya 4 Reaction Station is a 4-zone reaction station from Radleys, offering safe and precise heating, active cooling, software control and data-logging for 24/7 unattended chemistry. 

The Mya 4 Reaction Station, part of Radleys scientific tools, is a chemistry workstation for your reaction optimisation needs with maximum flexibility in a single piece of equipment from 2 ml to 400 ml vessels. 

The Mya 4 Reaction Station is a flexible chemical synthesis tool for a wide range of chemistry applications including: Process development, Design of Experiment (DoE), Scale up, Crystallisation studies, Route scouting, Polymorph screening, Lead optimisation, Single or parallel synthesis, Reaction optimisation, Reagent, catalyst & solvent screening, Crystallisation studies, medicinal chemistry.

For more information visit www.radleys.com/mya4
To book a demo visit: https://calendly.com/automated-reacti...  

Instagram: https://www.instagram.com/radleys_che...
Facebook: https://www.facebook.com/radleyschemi...
LinkedIn: https://www.linkedin.com/company/77309​
Twitter: https://twitter.com/Radleys​

#chemistry #reactionstation #medicinalchemistry

How to use vials/tubes with the Mya 4 Reaction Station for reaction optimization

Did you know the Radleys' Mya 4 Reaction Station vessels have been designed to give a gas tight seal? Dr Keren Abecassis shows you how a tight seal is important to ensure containment of chemicals during reactions.

A good way to show the tightness of the Mya 4 vessel seal is to apply vacuum. In this video we put a Mya 4 vessel assembly to the test with a vacuum pump.

A tight seal is useful if vacuum is needed. But more commonly, when refluxing solvents for long hours, this will prevent solvent loss between the vessel and the lid. And when working with toxic chemicals, it’s important to ensure these are contained.

The Mya 4 Reaction Station is a 4-zone reaction station from Radleys, offering safe and precise heating, active cooling, software control and data-logging for 24/7 unattended chemistry. 

The Mya 4 Reaction Station, part of Radleys scientific tools, is a chemistry workstation for your reaction optimisation needs with maximum flexibility in a single piece of equipment from 2 ml to 400 ml vessels. 

The Mya 4 Reaction Station is a flexible chemical synthesis tool for a wide range of chemistry applications including: Process development, Design of Experiment (DoE), Scale up, Crystallisation studies, Route scouting, Polymorph screening, Lead optimisation, Single or parallel synthesis, Reaction optimisation, Reagent, catalyst & solvent screening, Crystallisation studies, medicinal chemistry.

Process development work is much faster, with multiple temperature profiles run independently. With the Mya 4 Reaction Station, it’s quick and easy to set up Process Vessels with overhead stirring as well as performing automated chemistry.

Process development chemists and process development scientists worldwide use the Mya 4 Reaction Station for its accurate temperature control (controlling exothermic reactions safely), flexibility and ease-of-use. Read our case studies here: https://www.radleys.com/case-studies/...

For more information visit www.radleys.com/mya4
To book a demo visit: https://calendly.com/automated-reacti...   

Instagram: https://www.instagram.com/radleys_che...
Facebook: https://www.facebook.com/radleyschemi...
LinkedIn: https://www.linkedin.com/company/77309​
Twitter: https://twitter.com/Radleys​

#chemistry #laboratoryequipment #processdevelopment

Did you know? Mya 4 vessels give you a great seal - important for containing chemicals

Setting up overhead stirring is really quick and easy on the Mya 4 Reaction Station.

Setting up small-scale reactions with overhead stirring can sometimes be difficult and time consuming. With the Mya 4 Reaction Station, this is a thing of the past. Set up overhead stirrers in seconds. 

The Radleys Mya 4 Reaction Station is a chemistry workstation for your reaction optimisation needs with maximum flexibility in a single piece of equipment from 2 ml to 400 ml vessels. 

The Mya 4 Reaction Station is a flexible chemical synthesis tool for a wide range of chemistry applications including: Process development, Design of Experiment (DoE), Scale up, Crystallisation studies, Route scouting, Polymorph screening, Lead optimisation, Single or parallel synthesis, Reaction optimisation, Reagent, catalyst & solvent screening, Crystallisation studies, medicinal chemistry.

Process development work is much faster, with multiple temperature profiles run independently. With the Mya 4 Reaction Station, it’s quick and easy to set up Process Vessels with overhead stirring as well as performing automated chemistry.

Process development chemists and process development scientists worldwide use the Mya 4 Reaction Station for its accurate temperature control (controlling exothermic reactions safely), flexibility and ease-of-use. Read our case studies here: https://www.radleys.com/case-studies/...

For more information visit www.radleys.com/mya4
To book an online demo, visit: https://calendly.com/automated-reacti...

Instagram: https://www.instagram.com/radleys_che...
Facebook: https://www.facebook.com/radleyschemi...
LinkedIn: https://www.linkedin.com/company/77309​
Twitter: https://twitter.com/Radleys​

#chemistry #processdevelopment #laboratoryequipment

Did you know? It's really easy to set up overhead stirring on the Mya 4 Reaction Station

Watch the making a 10 Litre vacuum jacketed vessel from start to finish at Radleys. Starting from glass tubing, our expert scientific glassblower transforms the glass into a precision glass vessel ready to use in a Reactor-Ready Pilot frame. 

See the whole process from receiving a purchase order, manufacture, quality control and finally shipping to the customer. Our highly skilled scientific glassblowers have been creating beautiful scientific glassware like this 10 litre reaction vessel for over 50 years and we are also very proud to be training the next generation of glassblowers. 

The 10 L jacketed glass reactor vessel is part of our Reactor-Ready Pilot range, an innovative reaction work station for jacketed glass reactor vessels from 5 to 35 litres. Reactor-Ready Pilot is ideal for process development chemistry, scale-up, polymer chemistry, R&D, API manufacture and contract synthesis. Reactor-Ready Pilot replaces multiple reactor set-ups with a single, universal pilot scale system which allows the user to swap vessels in minutes NOT hours. 

Use one circulator and one framework to perform reactions on different scales from 5 to 35 litres, making it ideal for use in scale-up and process development chemistry labs. 

Reactor-Ready Pilot Features include:
• Rapid vessel exchange with quick-release vessel clamp and wide bore hose couplings. 
• Range of single jacketed vessels - 5, 10, 15, 20, 30 and 35 litres. 
• Range of vacuum jacketed vessels - 5 and 10 litres. • Vessels manufactured at 1.25 to 1 ratio of internal height to diameter to mimic plant scale reactors. 
• DN200 vessel flange. 
• Accepts all leading brands of overhead stirrer and allows easy, tool-free adjustment. 
• Compact stainless steel framework accepts all vessel sizes. 
• Self aligning stirrer coupling engages without the need for tools. 
• Temperature range: -70 ˚C to +230 ˚C (thermofluid temperature). •
 Innovative hose manifolds allow easy thermofluid drain down. 
• Wide range of accessory glassware including condensers, dropping funnels etc. 
• Optional software allows you to log and control 3rd party devices.

For more information regarding our jacketed lab reactor range visit: 
https://www.radleys.com/range/reactor...
To book an online demonstration: https://calendly.com/jacketed-lab-rea... 

Instagram: https://www.instagram.com/radleys_che... 
Facebook: https://www.facebook.com/radleyschemi... 
LinkedIn: https://www.linkedin.com/company/77309 
Twitter: https://twitter.com/Radleys

The making of a 10 L vacuum jacketed glass reaction vessel - scientific glassblowing

In this video we demonstrate how to correctly align the overhead stirrer on the Reactor-Ready jacketed lab reaction system. 

Correct alignment of your overhead stirrer will ensure there is no whip of the impeller, reducing the risk of wear on the stirrer guide bearing as well as PTFE shedding of the impeller into the vessel.

Radleys' Reactor-Ready jacketed laboratory reactor system, is designed as a universal jacketed lab reactor work station with a range of easily interchangeable vessels from 100 ml to 5 litres which can be configured to suit the chemistry and scale needed for each project. 

Easy to use, this one unique framework can replace many jacketed lab reactors, saving money and fumehood space by using one circulator with multiple setups. Reactor-Ready is ideal for organic chemistry, process chemistry, process development, medicinal chemistry, R&D research, polymer chemistry, academic research, API manufacture and CRO or contract synthesis. 

Reactor-Ready features: 

• Rapid vessel exchange with quick-release vessel clamps and wide bore hose couplings. 
• Range of standard (single and vacuum jacketed) glass reactor vessel – 250 ml to 5 L. 
• Range of process (single and vacuum jacketed) glass reactor vessel - 100 ml to 5 L Process Vessels. 
•Mimic the geometry of plant scale reactors and feature a 1.25 to 1 ratio of internal height to internal diameter, with dish shaped bottom. 
• DN100 vessel flange. 
• Accepts all leading brands of overhead stirring and allows easy, tool free adjustment. 
• Compact stainless-steel framework accepts all vessel sizes. 
• Self aligning stirrer coupling engages without the need for tools. 
• Temperature range: -70 ˚C to +230 ˚C (thermofluid temperature).
• Innovative hose manifolds allow easy thermofluid drain down. 
• Wide range of accessory glassware including condensers, dropping funnels etc. 
• Optional software allows you to log and control 3rd party devices. 

Reactor-Ready also offers a range of accessories such as condensers, temperature probes, glass and PTFE lids, PTFE impellers and reflux divider kits. You can also automate your jacketed lab reactor system with our AVA Lab Control Software which controls and data logs all the periphery devices connected to your jacketed lab reactor, such as overhead stirrers, circulators and gravimetric additions modules for accurate liquid dosing. 

For more information visit: https://www.radleys.com/range/reactor-ready-lab-reactor
Book a demo and learn more about Reactor Ready here: https://www.radleys.com/range/reactor-ready-lab-reactor/

Instagram: https://www.instagram.com/radleys_chemistry
Facebook: https://www.facebook.com/radleyschemistry
LinkedIn: https://www.linkedin.com/company/77309​
Twitter: https://twitter.com/Radleys​

#jacketedlabreactor #processchemistry #jacketed reactor

Radleys

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