Radleys

We speak to SAI Life Sciences about how they deliver scientific expertise to their clients and why partnering with Radleys for synthesis tools is key to their success. 

Andrew Kennedy - Vice President and Site Head Manchester and Jono West - Head of Safety & Scale Up, discuss the expectations that leading pharmaceutical and biotech companies have of their CRO partners and how Radleys synthesis equipment helps deliver the high-quality chemistry to meet their clients' needs. 

As chemists, the ability to operate synthesis in parallel allow SAI Life Sciences to obtain the right answers in a shorter period of time compared to traditional routes. This allows them to accelerate through their projects much quicker without any compromise. 

The Radleys Carousel is an effective parallel synthesis station which accommodates up to twelve reactions at a single temperature. In tandem, the synthesis station accommodates powerful stirring and reflux under an inert atmosphere. 

The Mya 4 Reaction Station adds the flexibility to operate in multiple zones; with precise temperature control; active cooling; in a range of different glass vessels and scales. Having the ability to screen up to 32 reactions at four different temperatures in small vials can accelerate the early stages of a project. 

As projects scale up, being able to conduct process development using glassware which starts to resemble that used downstream, adds further benefit. Reactor-Ready & Reactor-Ready Pilot jacketed lab reactors allow SAI Life Sciences to scale up in reaction vessels which mimic those used in their manufacturing plants. 

Ease of use and ability to change glass vessel size in under thirty minutes is highly advantageous. In addition, when moving through to pilot scales of up to 35 L the same appearance the lab reactors and mode of operation greatly aids the operation by chemists. 

AVA Lab Control software adds a further level of smart automation. Not only does it allow for the automated control of a reaction to allow unattended operation, the data logging of all parameters ensures no information is missed. This data lets the chemist understand the process safety and plan for further process scale up. 

For more information on the subjects and products discussed or to book a live demo with one of our experts visit: https://www.radleys.com/book 

Further information on the equipment featured: 
Parallel Reaction Stations https://www.radleys.com/range/parallel-reaction-stations/ 
Mya 4 Reaction Station: https://www.radleys.com/range/automated-reaction-stations/ 
Reactor-Ready Jacketed Lab Reactors: https://www.radleys.com/range/jacketed-lab-reactors/ 

Instagram: https://www.instagram.com/radleys_chemistry 
Facebook: https://www.facebook.com/radleyschemistry 
LinkedIn: https://www.linkedin.com/company/77309 
Twitter: https://twitter.com/Radleys

Learn how Radleys synthesis equipment is accelerating contract research at SAI Life Sciences

We speak to Dr Patrick Gilbert, Technical Director at Purolite, about the work Purolite do and how their chemical synthesis processes are benefitted by the Radleys Mya 4 reaction station.

Dr Gilbert, explains how Radleys Mya 4 Reaction Station has improved his productivity and is the daily workhorse in his lab. The vast temperature control over 4 stations along with its flexibility allows the lab to upscale skipping the reformulation step.

Dr Gilbert’s lab focuses on the functionalisation of resins with biomolecules, which are highly sensitive to temperature fluctuations. The team required a more reliable form of temperature control to replace hotplates and water/oil baths, including heating and cooling, as well as the availability of magnetic and overhead stirring. The Mya 4 Reaction Station was the perfect solution. 

The Mya 4 Reaction Station is a 4-zone reaction station, offering safe and precise heating, active cooling, software control and data-logging for 24/7 unattended chemistry. The Mya 4 Reaction Station is a chemistry workstation for your reaction optimisation needs with maximum flexibility in a single piece of equipment from 2 ml to 400 ml vessels. 

The Mya 4 Reaction Station is a chemical synthesis tool for a wide range of chemistry applications including: Process development, Design of Experiment (DoE), Scale up, Crystallisation studies, Route scouting, Polymorph screening, Lead optimisation, Single or parallel synthesis, Reaction optimisation, Reagent, catalyst & solvent screening, Crystallisation studies. 

Process development work is much faster, with multiple temperature profiles run independently. With the Mya 4 Reaction Station, it’s quick and easy to set up Process Vessels with overhead stirring. 

Setting up small-scale reactions with overhead stirring can sometimes be difficult and time consuming. With the Mya 4 Reaction Station, it’s quick and easy to put together Process Vessels with overhead stirring.

To book a demo visit: https://calendly.com/automated-reaction-stations
For more information, visit: https://www.radleys.com/range/automated-reaction-stations/

Instagram: https://www.instagram.com/radleys_chemistry
Facebook: https://www.facebook.com/radleyschemistry
LinkedIn: https://www.linkedin.com/company/77309​
Twitter: https://twitter.com/Radleys​

#temperaturecontrol #chemistry #processdevelopment

Streamlining chemical synthesis and process development with Radleys Mya 4 Reaction Station

Watch the parallel chemistry webinar here: https://register.gotowebinar.com/register/6774399415501441804
To watch any of our chemistry webinars visit: https://www.radleys.com/webinars

This webinar provides a hands-on walk through the Carousel 6 Plus and 12 Plus in detail. We look at all the tools and accessories in this range and run through the operation and setup. We include information on using a Carousel, running efficient reflux experiments and any necessary maintenance. 

Whether using a single position or all 12, the Carousel 12 Plus is an efficient way to perform chemical synthesis. Reduce time and save space in your chemistry laboratory by performing up to 12 chemical reactions in parallel on a single magnetic stirring hotplate. 

A great addition to your chemistry lab equipment and ideal for the following organic and inorganic chemistry applications: catalyst screening, medicinal chemistry, reaction screening, combinatorial chemistry, drug discovery, parallel solution phase chemistry, solid supported reagent based synthesis and much more. 

• Accepts up to 12 tubes with a reaction volume from 1 to 20 ml. 
• Powerful, even stirring - fits on to a Carousel Stirring Hotplate. 
• Rapid heating to 180 ˚C and cooling to -78 ˚C. 
• Quick to set-up and easy to use. 
• Easy viewing of tube contents during experiments. 
• Water-cooled reflux head. 
• Perform reactions under an inert atmosphere. 
• Fluoropolymer coating for chemical resistance and easy cleaning. 
• PTFE caps feature a ‘quick-thread’ for fast attachment to tubes. 
• Removable reflux head allows reaction tubes to be transferred between heated base, cooled base or stand. 

The Carousel 6 Plus Reaction Station simultaneously heat/cool, stir and reflux up to 6 reactions under an inert atmosphere using a single hotplate. A time- and space-saving way to set up 1 to 6 round bottom flasks on one stirring hotplate. A wide range of flasks available from 5 ml to 250 ml. Operating temperature range from -78 ˚C to +180 ˚C.

• Powerful, even stirring to all 6 positions - uses the 'Carousel principle' (secondary magnetic field)
• Use the hotplate for rapid heating up to 180 ˚C via the aluminium base.
• Integrated refluxing via the water-cooled reflux head - single source of water needed for all the reactions
• Inert all 6 reactions with a single inert gas connection.
• Use the Carousel cooling reservoir for cooling reactions down to -78 ˚C.

For more information on Carousel 12 Plus visit: https://www.radleys.com/range/carousel-12-plus-reaction-station
For more information on Carousel 6 Plus: https://www.radleys.com/range/carousel-6-plus-reaction-station/
To book an online demo visit: https://calendly.com/parallel-reaction-stations

Instagram: https://www.instagram.com/radleys_chemistry
Facebook: https://www.facebook.com/radleyschemistry
LinkedIn: https://www.linkedin.com/company/77309​
Twitter: https://twitter.com/Radleys​

#medicinalchemistry #multiplereactions #drugdevelopment

Chemistry webinar preview: Productivity and parallel Chemistry tools

Watch the Lab Reactor Webinar here: https://register.gotowebinar.com/register/8069564739301725710
To watch any of our chemistry webinars visit www.radleys.com/webinars 

This webinar discusses the many consideration made when choosing a jacketed lab reactor setup for scaling up your process chemistry. From the power of the overhead stirrer, to the cooling capacity of the circulator or even the geometry of your reaction vessel, these are all factors which can impact how your process performs and ultimately your final yield. In this webinar we cover the fundamental points of specifying the right reactor and ancillary devices to ensure that you get the optimal performance of your jacketed lab reactor system.

Radleys' Reactor-Ready jacketed laboratory reactor is designed as a universal jacketed lab reactor work station with a range of easily interchangeable vessels from 100 ml to 5 litres which can be configured to suit the chemistry and scale needed for each project. 

Easy to use, this one unique framework can replace many jacketed lab reactors, saving money and fumehood space by using one circulator with multiple setups. Reactor-Ready is ideal for organic chemistry, process chemistry, process development, medicinal chemistry, R&D research, polymer chemistry, academic research, API manufacture and CRO or contract synthesis. 

Reactor-Ready features: 

• Rapid vessel exchange with quick-release vessel clamps and wide bore hose couplings. 
• Range of standard (single and vacuum jacketed) glass reactor vessel – 250 ml to 5 L. 
• Range of process (single and vacuum jacketed) glass reactor vessel - 100 ml to 5 L Process Vessels. 
• Mimic the geometry of plant scale reactors and feature a 1.25 to 1 ratio of internal height to internal diameter, with dish shaped bottom. 
• DN100 vessel flange. 
• Accepts all leading brands of overhead stirring and allows easy, tool free adjustment. 
• Compact stainless-steel framework accepts all vessel sizes. 
• Self aligning stirrer coupling engages without the need for tools. 
• Temperature range: -70 ˚C to +230 ˚C (thermofluid temperature).
• Innovative hose manifolds allow easy thermofluid drain down. 
• Wide range of accessory glassware including condensers, dropping funnels etc. 
• Optional software allows you to log and control 3rd party devices. 

Reactor-Ready also offers a range of accessories such as condensers, temperature probes, glass and PTFE lids, PTFE impellers and reflux divider kits. You can also automate your jacketed lab reactor system with our AVA Lab Control Software which controls and data logs all the periphery devices connected to your jacketed lab reactor, such as overhead stirrers, circulators and gravimetric additions modules for accurate liquid dosing. 

For more information visit: https://www.radleys.com/range/reactor-ready-lab-reactor
To book a demo visit: https://calendly.com/jacketed-lab-reactors

Instagram: https://www.instagram.com/radleys_chemistry 
Facebook: https://www.facebook.com/radleyschemistry 
LinkedIn: https://www.linkedin.com/company/77309 
Twitter: https://twitter.com/Radleys 

#jacketedlabreactor #processchemistry #jacketedreactor

Chemistry Webinar Preview: Choosing a Jacketed Lab Reactor System

Watch the Mya 4 Webinar here: https://register.gotowebinar.com/register/4290443219076627214 
To watch any of our chemistry webinars visit: https://www.radleys.com/webinars

This chemistry webinar gives an introduction to the Mya 4 Reaction Station range from Radleys with a hands-on live demonstration. The Mya 4 Reaction Station is highly flexible with 4 independent zones and accurate temperature control, ideal for reaction optimisation and process development. 

The Mya 4 Reaction Station is a 4-zone reaction station, offering safe and precise heating, active cooling, software control and data-logging for 24/7 unattended chemistry. The Mya 4 Reaction Station is a chemistry workstation for your reaction optimisation needs with maximum flexibility in a single piece of equipment from 2 ml to 400 ml vessels. 

The Mya 4 Reaction Station is a chemical synthesis tool for a wide range of chemistry applications including: Process development, Design of Experiment (DoE), Scale up, Crystallisation studies, Route scouting, Polymorph screening, Lead optimisation, Single or parallel synthesis, Reaction optimisation, Reagent, catalyst & solvent screening, Crystallisation studies. 

Process development work is much faster, with multiple temperature profiles run independently. With the Mya 4 Reaction Station, it’s quick and easy to set up Process Vessels with overhead stirring. 

Setting up small-scale reactions with overhead stirring can sometimes be difficult and time consuming. With the Mya 4 Reaction Station, it’s quick and easy to put together Process Vessels with overhead stirring. 

For more information visit https://www.radleys.com/range/mya-4-reaction-station 
Book a demo at https://calendly.com/automated-reaction-stations 

Instagram: https://www.instagram.com/radleys_chemistry 
Facebook: https://www.facebook.com/radleyschemistry 
LinkedIn: https://www.linkedin.com/company/77309 
Twitter: https://twitter.com/Radleys 

#chemistrywebinar #chemistry #Mya4reactionstation

Chemistry Webinar Preview: Mya 4 for reaction optimization & process development

Watch the lab reactors webinar here: https://register.gotowebinar.com/register/7498425622787078926
To watch any of our chemistry webinars visit https://www.radleys.com/webinars

In this webinar we look at some considerations when designing a jacketed lab reactor system and their implications. We then follow on with some bespoke design options available for our jacketed reactors, where we review a variety of subjects including reactor geometry, thermal fluid connections, lid port design, drain valves and more illustrated with some examples of custom systems we have done for users. From the power of the overhead stirrer, to the cooling capacity of the circulator or even the geometry of your reaction vessel, these are all factors which can impact how your process performs and ultimately your final yield.

Radleys' Reactor-Ready jacketed laboratory reactor is designed as a universal jacketed lab reactor work station with a range of easily interchangeable vessels from 100 ml to 5 litres which can be configured to suit the chemistry and scale needed for each project. 

Easy to use, this one unique framework can replace many jacketed lab reactors, saving money and fumehood space by using one circulator with multiple setups. Reactor-Ready is ideal for organic chemistry, process chemistry, process development, medicinal chemistry, R&D research, polymer chemistry, academic research, API manufacture and CRO or contract synthesis. 

Reactor-Ready features: 

• Rapid vessel exchange with quick-release vessel clamps and wide bore hose couplings to ensure good HTF flow. 
• Range of standard (single and vacuum jacketed) glass reactor vessel – 250 ml to 5 L. 
• Range of single and vacuum jacketed glass reactor vessel - 100 ml to 5 L. 
• Mimic the geometry of plant scale reactors and feature a 1.25 to 1 ratio of internal height to internal diameter, with dish shaped bottom. 
• DN100 vessel flange. 
• Accepts all leading brands of overhead stirring and allows easy, tool free adjustment. 
• Compact stainless-steel framework accepts all vessel sizes. 
• Self aligning stirrer coupling engages without the need for tools. 
• Temperature range: -70 ˚C to +230 ˚C (thermofluid temperature).
• Innovative hose manifolds allow easy thermofluid drain down. 
• Wide range of accessory glassware including condensers, dropping funnels etc. 
• Optional software allows you to log and control 3rd party devices. 

Reactor-Ready also offers a range of accessories such as condensers, temperature probes, glass and PTFE lids, PTFE impellers and reflux divider kits. You can also automate your jacketed lab reactor system with our AVA Lab Control Software which controls and data logs all the periphery devices connected to your jacketed lab reactor, such as overhead stirrers, circulators and gravimetric additions modules for accurate liquid dosing. 

For more information visit: https://www.radleys.com/range/reactor-ready-lab-reactor
To book a demo visit: https://calendly.com/jacketed-lab-reactors

Instagram: https://www.instagram.com/radleys_chemistry 
Facebook: https://www.facebook.com/radleyschemistry 
LinkedIn: https://www.linkedin.com/company/77309 
Twitter: https://twitter.com/Radleys 

#jacketedlabreactor #processchemistry #jacketedreactor

Radleys

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