Radleys

In this video we demonstrate how to maintain your Heidolph rotary evaporator. We will show you how to disassemble the glassware and clean it, how to inspect and clean the vacuum seal and finally how to reassemble the glassware ready for evaporation and efficient distillations.

Regular maintenance of your rotary evaporator will ensure that it stays in top working condition and gives the best vacuum tightness for efficient distillations. Keeping your rotary evaporator well maintained will also reduce the risk of cross contamination of different samples when evaporating different batches of products.

The Hei-VAP series of rotary evaporators from Heidolph are ideal for evaporating, distilling and extracting solvents. The Hei-VAP benchtop rotary evaporators are used around the world for chemical research, organic chemistry, medicinal chemistry, process development, solvent recovery, solvent recycling, CBD extractions, product drying etc. 

The Hei-VAP rotary evaporators feature:
• Industry leading safety features
• Easy to remove glass vapour tube, clamping sleeve and graphite filled PTFE seal, engineered to reduce wear and consumption of spares by up to 75%
• Patented Easy-Clip flask clamp enables removal of flasks from the drive, without jamming
• 3 year warranty standard on all Hei-VAP models
• Novel detachable operating panel, which allows precise control of all important parameters outside the fume hood. 
• Upgraded design of heating bath has IP67 rating, heats to an unmatched 210°C, accepts large flasks up to 5 litres and features a convenient pouring spout for spill free emptying
• Optional plastic coated glass sets to protect you from implosions
• Unbeatable lowest cost of ownership throughout the life of the Hei-VAP Rotary Evaporator
• Rotation speed and heating bath temperature are controlled by two separate operating knobs which are illuminated by LED ring lights
• Both controls can be locked to prevent accidental changing of the values, perfect for teaching labs
• Heating knob lights up orange to indicate when heating is active and when in standby mode, blinks when the bath is over 50 ˚C to prevent burns
• Display panel is made of glass-bead strengthened material that is splash water resistant in accordance with IP 42
• Heating bath has new ergonomic handles and pour spout to make emptying safe and simple. It also has an IP 67 rated power cable to protect against short circuits and corrosion

Find out more at https://www.radleys.com/range/hei-vap-rotary-evaporators/
To book a demo, visit: https://calendly.com/heidolph-instruments

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#heidolph #organicsynthesis #solventextration

How to maintain your rotary evaporator for distillations and solvent extractions

In this video, Dr Nilesh Mistry gives you an introduction to the Radleys parallel synthesis range and an insight into how they may help your small molecule synthesis projects. 

Working on small molecule discovery, reaction optimisation or reagent screening? 
Need to increase your experimental throughput without compromising on your set-up? 
Want to perform multiple reactions in parallel, but have limited fume hood space? 

Chemists and engineers at GlaxoSmithKline were instrumental in developing a range of clever parallel synthesis tools designed to tackle performing multiple reactions on one magnetic stirrer hot plate. 

Developed in a partnership between GSK chemists and Radleys engineers: The Radleys Carousel 12, Radleys Carousel 6 and the Radleys GreenHouse parallel synthesiser and blowdown unit are easy to use, perform multiple reactions, fit on a standard magnetic stirrer hot plate and take up less space than multiple individual set-ups. 

Parallel synthesis tools are a great addition to your chemistry lab equipment and ideal for the following organic and inorganic chemistry applications: medicinal chemistry, reaction screening, combinatorial chemistry, catalyst screening, drug discovery, parallel solution phase chemistry, solid supported reagent based synthesis and much more. 

Heat, cool, stir and reflux multiple reactions under an inert atmosphere on a single magnetic stirrer hot plate. 

Carousel 12 Plus Reaction Station: 
The patented Carousel 12 Plus simultaneously heats/cools, stirs and refluxes multiple reactions under an inert atmosphere. An effective personal synthesis station for parallel chemistry and solid supported reagent screening synthesis. 
• Accepts up to 12 glass tubes with a reaction volume from 1 ml to 20 ml 
• Powerful, even stirring – fits on to a Carousel stirring hotplate 
• Rapid heating to 220 ˚C and cooling to -78 ˚C 
• Quick to set-up and easy to use 
• Easy viewing of tube contents during experiments 
• Removable water-cooled refluxing head 

GreenHouse Plus Parallel Synthesiser: 
The GreenHouse Plus provides 24 heated and stirred glass reactions with volumes from 0.5 ml to 7 ml. The refluxing head allows for convenient additions or withdrawals whilst maintaining an inert atmosphere. 
• Powerful stirring and rapid heating to 150 ˚C 
• 24 tube, micro titer plate footprint 
• Reaction volumes from 0.5 ml to 7 ml 
• Removable water-cooled reflux head 
• Perform reactions under an inert atmosphere 
• Easy viewing of tube contents during experiments 
• Nickel plated aluminium offers excellent chemical resistance 

Carousel 6 Plus Reaction Station: 
The patented Carousel 6 Plus offers parallel chemistry in the most universally accepted chemistry reaction vessel, the round bottom flask. 
• Accepts round bottom flasks, including vessels with one or two sidearms: 5 ml, 10 ml, 25 ml, 50 ml, 100 ml, 170 ml and 250 ml. 
• Powerful, even stirring – fits on to a Carousel stirring hotplate 
• Rapid heating to 180 ˚C and cooling to -78 ˚C 
• Quick to set-up and easy to use 
• Water-cooled reflux head 

For more information on this range visit https://www.radleys.com/range/parallel-reaction-stations 
To book a demo with an expert visit: https://calendly.com/parallel-reaction-stations 

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#chemistry #realtimechem #parallelsynthesis

Parallel synthesis tools for small molecule drug discovery and medicinal chemistry

In this video we demonstrate how to set up a jacketed lab reactor with a circulator. 

We go through the components that make up a jacketed lab reactor system and the tools you need for doing the installation. We then show how to set up a lab reactor (Reactor-Ready) connected to a circulator and fill the system with thermal fluid. Finally, we demonstrate the process of draining the thermal fluid from the system via the drain down manifolds and then show how to swap vessels in the reactor framework.

Reactor-Ready is designed as a universal jacketed lab reactor system with a range of easily interchangeable vessels from 100 ml to 5 litres which can be configured to suit the chemistry and scale needed for each project. The jacketed lab reactor system is easy to use, this one unique framework can replace many, saving money and fumehood space by using one circulator with multiple setups. Reactor-Ready is ideal for organic chemistry, process development, medicinal chemistry, R&D research, polymer chemistry, academic research, scale up, API manufacture and CRO or contract synthesis. 

Reactor-Ready features: 

• Rapid vessel exchange with quick-release vessel clamps and wide bore hose couplings. 
• Range of standard (single and vacuum jacketed) glass reaction vessels – 250 ml to 5 L. 
• Range of process (single and vacuum jacketed) glass reaction vessels - 100 ml to 5 L Process Vessels. mimic the geometry of plant scale reactors and feature a 1.25 to 1 ratio of internal height to internal diameter, with dish shaped bottom. 
• DN100 vessel flange. 
• Accepts all leading brands of overhead stirrer and allows easy, tool free adjustment. 
• Compact stainless-steel framework accepts all vessel sizes. 
• Self aligning stirrer coupling engages without the need for tools. 
• Temperature control range: -70 ˚C to +230 ˚C (thermofluid temperature).
• Innovative hose manifolds allow easy thermofluid drain down. 
• Wide range of accessory glassware including condensers, dropping funnels etc. 
• Optional software allows you to log and control 3rd party devices. 

For more information visit: www.radleys.com/range/reactor-ready-lab-reactor
To book an online demonstration: https://calendly.com/jacketed-lab-reactors

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How to set up a Jacketed Lab Reactor with a circulator - Reactor-Ready

In this video we demonstrate the key features of the Reactor-Ready Duo jacketed lab reactor system. Reactor-Ready Duo is an innovative benchtop reaction work station with interchangeable jacketed glass reactor vessels with volumes from 100 mL to 5 litres. 

Reactor-Ready Duo holds two independent jacketed reactor vessels in a single compact framework. The system can be configured to operate with a single thermoregulator or circulators controlling the jacket temperature of both vessels simultaneously; or with two thermoregulators controlling the temperature of each vessel independently. 

Reactor-Ready Duo is ideal for organic chemistry, process development, medicinal chemistry, R&D research, polymer chemistry, academic research, API manufacture and CRO or contract synthesis.   

Reactor-Ready Duo can be used for:
• Parallel synthesis or reaction optimisation, using similar or different size vessels and varying stirring speed, stirrer shape and temperature between vessels.
• Two stage reactions where you can transfer reactant from one vessel to the other using vacuum or a pump.
•Or as a single reaction vessel, using the second vessel as either a receiving or feed vessel (where reagents can be pre-heated or pre-cooled prior to addition).

Reactor-Ready Duo also offers a range of accessories such as condensers, temperature probes, glass and PTFE lids, PTFE impellers and reflux divider kits. You can also automate your jacketed lab reactor system with our AVA Lab Control Software which controls and data logs all the periphery devices connected to your jacketed lab reactor, such as overhead stirrers, circulators and gravimetric additions modules for accurate liquid dosing. 

Reactor-Ready Duo Features include: 
• Holds two chemical glass reaction vessels
• Rapid vessel exchange with quick-release vessel clamps and wide bore hose couplings.
• Range of standard (single and vacuum jacketed) vessels – 250 ml to 5 L.
• Range of process (single and vacuum jacketed) vessels - 100 ml to 5 L Process Vessels. mimic the geometry of plant scale reactors and feature a 1.25 to 1 ratio of internal height to internal diameter, with dish shaped bottom.
• DN100 vessel flange. 
• Accepts all leading brands of overhead stirrer and allows easy, tool free adjustment. 
• Compact stainless steel framework accepts all vessel sizes. 
• Self aligning stirrer coupling engages without the need for tools. 
• Temperature range: -70 ˚C to +230 ˚C (thermofluid temperature). 
• Innovative hose manifolds allow easy thermofluid drain down. 
• Wide range of accessory glassware including condensers, dropping funnels etc. 
• Optional software allows you to log and control 3rd party devices. 

Book a demo and learn more about Reactor Ready Duo here: https://www.radleys.com/range/reactor-ready-duo-lab-reactor

Reactor-Ready Duo jacketed glass reactor - two interchangeable vessels on one framework

When magnetic stirring is not enough (e.g. viscous materials, heterogeneous mixtures), there is usually a need for mechanical stirring, or overhead stirring. But setting up overhead stirrers on a small scale can be expensive, limited by fumehood space, and time-consuming, especially for multiple reactions.

With the Tornado Overhead Stirring system from Radleys, you can stir up to 6 round bottom flasks with single overhead stirrer. Each reaction can be set up in seconds.

Tornado is an add-on to the popular Carousel 6 Plus Reaction Station. When combined, they allow you to heat, mechanically stir and reflux 1 to 6 reactions under an inert atmosphere.

The Tornado will work with all popular brands of overhead stirrer including the Heidolph Hei-TORQUE and IKA Eurostar brands.

This video shows a demonstration of the Tornado Overhead Stirring system including: 
• Key features and benefits
• Glassware assembly
• Magnetic stirring vs Tornado overhead stirring with a range of common fluids and viscosities.

If you want to find out more about the Carousel 6 Plus Reaction Station, you can watch a demonstration here: https://youtu.be/vQHDjfNoASY

The Tornado allows powerful, controlled mechanical stirring of up to six round bottom flasks when combined with the Carousel 6 Plus Reaction Station; offering unrivalled stirring for both viscous samples and for the dispersion of delicate solids in solution.

• Integrates with Carousel 6 Plus to provide heated and stirred reactions
• Rapid heating to 180 ˚C, with water-cooled reflux head
• Perform reactions under an inert atmosphere
• Accepts 50 ml, 100 ml and 250 ml round bottom flasks
• Uses a single overhead stirrer – save space and money compared with multiple set-ups
• Compatible with all leading brands of overhead stirrer
• 2-speed drive allows overhead stirrers with less torque to be used for higher viscosities

To book a live Tornado demonstration with an expert click here:https://calendly.com/parallel-reaction-stations/tornado-demo-with-an-expert-by-video?month=2021-01

Tornado - Powerful mechanical stirring of multiple chemical reactions with one overhead stirrer

This video demonstrates how simple it is to connect a device to AVA Lab Control Software and automate your Jacketed Lab Reactor. AVA allows you to automate your chemistry, to perform controlled additions with your organic reactions and control your jacketed reactor. Our laboratory software will control up to 4 reaction systems as well as control and data log multiple devices connected to any lab reactor or lab reactor system.

Control up to 4 reaction systems with up to 16 devices on one screen
Create complex experiments with any number of steps in series or parallel
Pre-program multi-step recipes, with the flexibility to make and track on-the-fly adjustments
Interlink devices and set feedback/control loops, end-point conditions and safety limits
Automate cooling of your Jacketed Lab Reactor during exothermic events
Link devices such as balances and pumps for controlled, unattended reagent addition
Define safety overrides and cut-off conditions

With AVA, reaction parameters are automatically logged so that the user is able to repeat experiments accurately for reproducible and consistent results. Reports can be created in a few clicks and the data can be exported as a CSV file for further analysis making it a powerful tool for process chemists, kilo labs, research and development and scale-up chemists alike.

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