Spectrum Labs

Spectra/Por® Dialysis

Spectrumlabs.com is proud to offer the New KMPi TFF System for Lab and Pilot Bioprocessing. The KMPi is a Fully Integrated System, with Single-Use Capabilities, and Automated Functions for precise and reproducible control. Tracking Process Development, with Extensive Documentation and Reliable Analysis for Simple Standardization of Procedures in Biotech, Vaccines, Gene Therapy, Drug Delivery, and many other applications. 

Specifically designed to support Microfiltration and Ultrafiltration from 10 liters to 500 liters, the KMPi System is Robust, and Versatile. Equipped with Spectrum’s modified polyethersulfone membranes, for excellent selectivity, higher flux, and faster processing times. The KMPi system enhances a variety of bioprocessing applications.

Spectrum’s Sterile and Ready-to-Use Flow Paths feature Non-Invasive Components for Operational Simplicity and Quality Assurance. The digitally controlled peristaltic pump with reversible motor is powerful. Delivering precision flow control during all operations, with a compact design to minimize laboratory footprint. Accurate and Disposable, Polysulfone Pressure Transducers report valuable data and process details to the System. Communicating critical information to the technician, through the Digital Pressure Monitor. Live from the application! The KMPi measures, calculates, and displays Real-Time Pressure and scale readings to help maximize product recovery. Permitting a vast array of user-defined alarms, and set points to safely maintain operation.

For Ease of Use, all KMPi settings and configurations can be input; either, at the pump console, or by computer. With KFComm, Spectrum’s Data Collection Software. The KFComm Program is Fully Accessible, enabling Instant Analysis while maintaining complete control of the entire process. Allowing Operators to set process parameters, and walk away; during Complex, Long Runs of Large-Batch Pilot Studies. Meanwhile, KFComm digitally records and catalogs all important criteria. Users can easily program; high weight, low weight and pressure alarms, or fine tune application set-points. Using one of five Automated Sequences, or Manual Mode. Simply, input the Concentration Factors, and Diafiltration Volumes; and the KMPi will calculate the rest.Real-time overviews of the Filtration Process will generate quickly. So you can comfortably track progress; and ensure the reproducibility of separations.

Optimize your TFF process development with Consistent Control and Dependable Feedback from the KMPi System.
by Spectrumlabs.com
Advancing the science of separation.

The KMPi TFF System from Spectrumlabs.com

SpectrumLabs.com presents the next technological advancement in Filtration. The KML™ 100 (KrosFlo® MagLev), is a Benchtop Perfusion and TFF System, maximizing convenience and flexibility for Continuous Cell Perfusion and Tangential Flow Filtration. The KML is ideal for maintaining cell viability, and increasing production of biological drugs, at processing volumes ranging from 2 Liters to 100 Liters. Utilizing modified polyethersulfone membranes, the KML benchtop system creates a conducive environment for cell growth, removing problematic enzymes. The KML has 5 modes of TFF control, for a variety of concentration and diafiltration recipes. Or, a perfusion mode, tailored to your specific bioreactor’s needs. Spectrum’s unique flow path design provides increased process efficiency, and ensures cell viability. The low shear magnetic levitating pump creates a consistent, gentle flow that eliminates pulsation to protect your sample throughout the automated process. Additionally, low residence time of cells outside the bioreactor provides the optimal conditions for cell growth. Built-in communication between components keep the KML system constantly up-to-date and in-sync. Automatically controlling pressures, flows, and weights. Maintaining pressures for optimal process flux; matching flow set-points for a consistent consistent RPM’s. All while, balancing the flow rate of media addition and permeate flow. ￼￼￼￼￼￼￼Simply input your unique specifications ahead of time with Spectrum’s load cell set-point controls. And, let the KML do the rest. Spectrum’s color touch screen displays real-time data for important process parameters, to ensure product safety, the KML system incorporates visible and audible alarm systems, with safety interlocks during operation. Real-time graphs will collect requested data, eliminating tedious clerical work in the lab. Once completed, USB Data Collection is simple. Ready to go, and available at your finger tips. The KML’s compact design minimizes your laboratory footprint. The detachable flow path stand expands your arrangement options and flexibility. Making the KML easily adaptable to any laboratory set-up or style. The KrosFlo MagLev Benchtop System from Spectrum Labs. Advancing the Science of Separation, and Cell Expansion!

The KML™ 100 - Benchtop Perfusion and TFF System

Throughout Science, flow-paths take many shapes. This is particularly true on the Journey across Tangential Flow Filtration. With process efficiency as our aim, let’s examine the differences between hollow fiber and cassette filtration. 

Hollow Fiber Filters from Spectrum Labs ship as one all-inclusive package compared to the additional costs incurred from the multitude of components needed in cassette filtration systems. Cassette systems require multiple filters and a manifold to do the work of one Hollow Fiber Module; which utilizes a contained disposable filter, ideal for easy setup. In addition, Spectrum’s state-of-the-art digital pressure sensors enable increased accuracy, compared to old analog gauges traditionally used in cassette filtration. Spectrum Lab’s Hollow Fiber technology is Ready-to-Use, taking set up time from hours to minutes. In cases of over-torque, pressure can exceed limitations, compromising the membrane and collapsing channel walls. Under normal operating procedures, cassette filters employ a tortuous flow path. Whereas Hollow Fiber filtration is linear and concise; creating a smooth tract for more gentle separations. For the most efficient and precise processing possible.

Let’s take a closer look at the different flow paths.
Inside the cassette filter, particles must travel through a strenuous and complicated flow path. With Hollow Fiber Filters from Spectrum Labs, your sample moves through a simple, linear flow path, maintaining smooth and gentle flow. Cassette configuration centers around a flat sheet design, which use screens as turbulence promoters to direct flow and disperse particles. With hollow fiber filtration from Spectrum Labs, the open channel design protects your product by creating an unobstructed pathway, increasing recovery. The tubular geometry allows for efficient processing of greater yields in less time. Hollow fiber filters from Spectrum Labs allow for Optimal Drainability which results in a higher profit margin. 

Additionally, Spectrum Labs Hollow Fiber Filters are scalable, ensuring consistent and reliable results from laboratory R&D to full-scale production. The results are clear ... save money, and setup time... enhance your system’s flow path... increase your recovery and yield potential. 

Optimize Process Efficiency with Ready-to-Use Hollow Fiber Technology from Spectrum Labs.

Hollow Fiber vs. Cassette Filtration

Spectrum Labs is proud to introduce the KrosFlo Perfusion System. As a leader in perfusion innovation, Spectrum Labs has focused on improving cell culture yields by simplifying operations. Utilizing modified polyethersulfone membranes, ... the KrosFlo perfusion system creates a conducive environment for cell growth, and increases the amount of expressed proteins... creating a high quality product by removing problematic enzymes. The specific hollow fiber geometry is perfect for large membrane capacities,... and achieves extremely high cell densities,... while maintaining cell viability. With sterile, disposable and ready-to-use components, KrosFlo Perfusion Systems combine convenience with optimal performance. The KrosFlo Perfusion System eliminates the autoclaving process, taking set up time from hours to minutes. Spectrum's KPS Systems are designed specifically to lower the residence time of cells outside the bio-reactor. This minimizes damage to the cells, while creating a low shear, smooth flow-path, without changing cell viability or function. In addition, the gentle flow rate is ideal for Perfusion, and eliminates pulsations creating stable pressure profiles. Also equipped with non-invasive components, and an LCD touch screen to control and maintain critical operation parameters. The KPS Systems, with capabilities from 2-2000 Liters; can handle Lab, Pilot, and Production Scale Bioreactors. For greater flexibility and a small laboratory footprint, the KML System accommodates low volume perfusion at an affordable price. KrosFlo Perfusion Systems from Spectrum Labs Advancing the science of separation, and cell expansion.

KrosFlo® Perfusion Systems from Spectrum Labs

Spectrum introduces the new Micro Float-A-Lyzer® to expand our popular line of ready-to-use dialysis devices for the easy and efficient dialysis of very small sample volumes (100-500 µl). Providing ultimate convenience, this preassembled device incorporates Spectrum's ultrapure Biotech Grade Cellulose Ester (CE) tubular membrane into an easy-to-use design making laboroatory microdialysis easier than ever. Micro Float-A-Lyzer is available in 2 volumes sizes: 100 - 200 µl &amp; 400 - 500 µl; and 7 concise MWCO's ranging from 100 - 100,000 Daltons.

micro Float-A-Lyzer® Ready-to-Use Microdialysis Device

Spectrum's 2nd Generation Float-A-Lyzer G2, the easy and smart ready-to-use dialysis device.

Spectrum Labs

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