SiliCycle Inc.

E-PAK is a family of radial flow purification cartridges developed specifically for pharmaceutical processing from the lab scale all the way up to commercial sizes. 

Scaling up is easy when  it comes to E-PAK as it follows a linear trend, that way you can be sure that your lab results can be easily achieved at pilot and commercial purification steps.    

Offered with a choice of metal scavengers, bare silica or activated carbons, these cartridges are designed to remove precious metal catalysts, reaction-by-products or color from synthetic reaction mixtures and natural products.

For more information on E-PAK, visit us at: https://www.silicycle.com/ca/products/e-pak-purification-cartridges

Have questions about metal scavengers? Visit our FAQ page: https://www.silicycle.com/ca/faq/metal-organic-scavengers

Impurity Scavenging Scale-up with E-PAK Technology - Webinar

New to metal and organic scavengers? Not too sure what they are?

Our silica expert goes over these and other popular questions to give the basics of scavengers, so that you have a good understanding within 6 minutes. 

This min-webinar answers:
- What are scavengers
- Why use them
- How to use them
- Selecting a scavenger
- Optimizing scavenging efficiency

If interested in knowing more about scavengers, resources are available on our website. These include:
- FAQ section - https://www.silicycle.com/ca/faq/metal-organic-scavengers
- Application Notes - https://www.silicycle.com/ca/resource-center/application-notes
- Portfolio overview and selection guide - https://www.silicycle.com/ca/products/metal-scavengers


Quick Introduction to Metal and Organic Scavengers - Webinar

The SiliaMetS E-PAK Technology combines the years of expert purification that SiliCycle is known for, in an easy-to-use pre-packed cartridge for maximum ease and convenience. 

E-PAK radial flow cartridges provide rapid adsorption kinetics and processing capacities for laboratory, pilot and commercial operations. They are designed for use with both organic and aqueous solvents, and incorporate design features useful for the production of active pharmaceutical ingredients (API).

Features include:
• Proven cartridge design to ensure rapid, simple & reliable technology
• Fixed-bed design ensuring safer handling, clean-up and disposal
• Large adsorbent capacity in small area footprint increases product recovery & reduces solvent requirements

Offered with a choice of metal scavengers, bare silica & activated carbons, these cartridges are designed to remove precious metal catalysts, reaction-by-products or color from synthetic reaction mixtures and natural products.

They are four ways/ configurations that one can use E-PAK cartridges:
-Single Pass
-Recirculation
-Multi pass
-Series pass
Watch the video to see each one in action. 

For more information on E-PAK, visit us at: https://www.silicycle.com/ca/products/e-pak-purification-cartridges

Also be sure to check out our Application Notes library to see industry examples of when and how to use E-PAK: https://www.silicycle.com/ca/resource-center/application-notes

Metal Scavenging from Lab to Production Scale with E-PAK Technology - Webinar

Solid-phase extraction (SPE) is a technique designed for rapid sample preparation, purification and/or concentration prior to chromatographic analysis.  

SPE uses a sorbent that has a strong affinity for the desired compound and solvent changes to collect the individual components as single fractions.
After applying the sample to a pre conditioned column, the column is eluted with a solvent that has a weak affinity for the desired product to removed impurities. It is then eluted with a solvent that has a strong affinity for the desired product thereby displacing it from the sorbent. 

Common sample matrices include: 

• human and animal biological fluids
• waste waters
• petrochemical residues
• toxicological residues

To check out SiliCycle's SiliaPrep SPE product line and the various sorbents available, visit: https://www.silicycle.com/products/silicycle-sample-preparation-products/spe-cartridges

To see different applications and their protocols, you can find case studies in our Sample Prep Brochure: https://www.silicycle.com/media/brochure/silicycle-BROSAM-brochure-sample-preparation-web.pdf

The 5 steps of a solid phase extraction (SPE)

Get a quick overview on how a sample is analyzed using High Performance Liquid Chromatography (HPLC).

As the sample mixture in the mobile phase is pumped into the column, the analytes or compounds in it interact with the stationary phase (ie sorbent). The overall interactions make it that the compounds get retained with varying strength, thereby affecting when they exit the column. The detector at the exit records this elution and the information generates the chromatogram. 

Have more questions regarding HPLC? SiliCycle has compiled a list of the most frequently asked questions here: https://www.silicycle.com/faq/hplc 

If new to HPLC, it is also important to note that keeping the column in top condition with proper care will help to maintain column efficiency over an extended period of time, so you can continue your testing for as long as possible. This Application Note shares different procedures used to help extend the lifetime of HPLC columns. https://www.silicycle.com/resource-center/application-notes/hplc-columns-cleaning-regeneration-procedures

HPLC Analysis in a nutshell - How a sample is analyzed 

E-PAK is a family of radial flow purification cartridges that linearly scale-up from lab to commercial processing sizes, which means that lab conditions and results are easily reproducible. 

They are four ways/ configurations that one can use E-PAK cartridges:
-Single Pass
-Recirculation
-Multi pass
-Series pass

Watch the video to see each one in action. 

For more information on E-PAK, visit us at:
https://www.silicycle.com/products/e-pak-purification-cartridges

Also be sure to check out our Application Notes library to see industry examples of when and how to use E-PAK:  
https://www.silicycle.com/resource-center/application-notes


SiliCycle Inc.

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