Abgent 

An overview of Autophagy, one of the most important biological processes. Autophagy is a cellular degradation process that involves the delivery of cytoplasmic cargo to the lysosome. Autophagy occurs at low basal levels in all cells to maintain homeostatic functions such as protein and organelle turnover. 

It is rapidly upregulated when cells need to generate intracellular nutrients and energyd during starvation, growth factor withdrawal, or high bioenergetic demands. Autophagy is also important process to dispose of damaging cytoplasmic components during oxidative stress, infectionor protein aggregate accumulation. Consequently, impairment in autophagy can lead todevelopment of certain pathological conditions. 

Autophagy Review

New antibodies from Abgent – G protein-coupled receptors.  These new antibodies complement the range of over 20,000 antibodies available from Abgent.  Visit www.abgent.com for our full range of antibodies, blocking peptides, synthetic peptides, cell and tissue lysates and more.  G protein-coupled receptors (GPCRs) are a large protein family of receptors that sense molecules outside the cell and activate inside signal transduction pathways and, ultimately, cellular responses. They are called transmembrane receptors because they pass through the cell membrane, and furthermore, they are called seven-transmembrane receptors because they pass through the cell membrane seven times.   They are also known as seven-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptor, and G protein-linked receptors (GPLR).

Abgent GPCR

At Abgent, the majority of our antibodies are produced in-house, and these antibodies undergo a rigorous validation process by Abgent scientists. However, a number of our most important antibodies meet highly aggressive quality requirements. These products, and many more under review and development, are labeled with a "Crown."
Products labeled with a "Crown" meet stringent requirements in terms of specificity, sensitivity, and reproducibility.

- All western blots show bands at the correct molecular weight, and any deviation or additional bands have been verified to be due to post translational modifications, isoforms, or cleavage products. 
- Results are supported by peer reviewed literature and/or by the most relevant bioinformatics sites, i.e. Human Protein Atlas. 
- Many of these products are validated and optimized in additional applications including immunofluorescence and subcellular localization is verified using peer reviewed literature. 
- New lots are verified to perform as well or better than the previous lots in each application and species tested. 


Crown Antibodies

Abgent launches 250 new Neurodegeneration antibodies

Neurodegeneration

Abgent antibodies validated for Immunofluorscence. View a selection of our Immunofluorescence Antibodies. Visit our website for our full range.

Immunofluorescence Antibodies

Realtime Clear is a unique protein stain for SDS PAGE. For more information contact eurosales@abgent.com - Tel: +44 (0)1628 639753.  
It is unique in that it stains the protein whilst it is running in the gel – it is truly REALTIME!
• Fast, saves time, results visible as the gel is running
• Cost effective, no need for sample loading buffer, pre-stained protein ladders or traditional Coomassie staining
• Sensitive, limit of detection 50ng 
• Stable, store at room temperature, shelf life of 1 year
• Flexible, optimise the staining protocol to match your sample requirements
• Make their own pre-stained protein ladders!
• Bonds covalently to the amine group, is permanent
• Optimised for purified or partially purified proteins

Abgent

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